Abstract：
:Five species of parasite cause malaria in humans with the most severe disease caused by Plasmodium falciparum. Many of the proteins encoded in the P. falciparum genome are unusually enriched in repetitive low-complexity sequences containing a limited repertoire of amino acids. These repetitive sequences expand and contract dynamically and are among the most rapidly changing sequences in the genome. The simplest repetitive sequences consist of single amino acid repeats such as poly-asparagine tracts that are found in approximately 25% of P. falciparum proteins. More complex repeats of two or more amino acids are also common in diverse parasite protein families. There is no universal explanation for the occurrence of repetitive sequences and it is possible that many confer no function to the encoded protein and no selective advantage or disadvantage to the parasite. However, there are increasing numbers of examples where repetitive sequences are important for parasite protein function. We discuss the diverse roles of low-complexity repetitive sequences throughout the parasite life cycle, from mediating protein-protein interactions to enabling the parasite to evade the host immune system.
journal_name
FEMS Microbiol Revjournal_title
FEMS microbiology reviewsauthors
Davies HM,Nofal SD,McLaughlin EJ,Osborne ARdoi
10.1093/femsre/fux046subject
Has Abstractpub_date
2017-11-01 00:00:00pages
923-940issue
6eissn
0168-6445issn
1574-6976pii
4564189journal_volume
41pub_type
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