Abstract：
:Antibiotic resistance is one of the few examples of evolution that can be addressed experimentally. The present review analyses this resistance, focusing on the networks that regulate its acquisition and its effect on bacterial physiology. It is widely accepted that antibiotics and antibiotic resistance genes play fundamental ecological roles - as weapons and shields, respectively - in shaping the structures of microbial communities. Although this Darwinian view of the role of antibiotics is still valid, recent work indicates that antibiotics and resistance mechanisms may play other ecological roles and strongly influence bacterial physiology. The expression of antibiotic resistance determinants must therefore be tightly regulated and their activity forms part of global metabolic networks. In addition, certain bacterial modes of life can trigger transient phenotypic antibiotic resistance under some circumstances. Understanding resistance thus requires the analysis of the regulatory networks controlling bacterial evolvability, the physiological webs affected and the metabolic rewiring it incurs.
journal_name
FEMS Microbiol Revjournal_title
FEMS microbiology reviewsauthors
Martinez JL,Fajardo A,Garmendia L,Hernandez A,Linares JF,Martínez-Solano L,Sánchez MBdoi
10.1111/j.1574-6976.2008.00142.xsubject
Has Abstractpub_date
2009-01-01 00:00:00pages
44-65issue
1eissn
0168-6445issn
1574-6976pii
FMR142journal_volume
33pub_type
杂志文章,评审abstract：:Gene conversion is defined as the non-reciprocal transfer of information between homologous sequences. Despite methodological problems to establish non-reciprocity, gene conversion has been demonstrated in a wide variety of bacteria. Besides examples of high-frequency reversion of mutations in repeated genes, gene con...
journal_title：FEMS microbiology reviews
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journal_title：FEMS microbiology reviews
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journal_title：FEMS microbiology reviews
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journal_title：FEMS microbiology reviews
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更新日期：1990-09-01 00:00:00
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journal_title：FEMS microbiology reviews
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journal_title：FEMS microbiology reviews
pub_type： 杂志文章
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更新日期：1994-08-01 00:00:00
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更新日期：2009-05-01 00:00:00
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journal_title：FEMS microbiology reviews
pub_type： 杂志文章,评审
doi：10.1111/j.1574-6976.1995.tb00213.x
更新日期：1995-10-01 00:00:00
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journal_title：FEMS microbiology reviews
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journal_title：FEMS microbiology reviews
pub_type： 杂志文章,评审
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更新日期：1993-08-01 00:00:00
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journal_title：FEMS microbiology reviews
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journal_title：FEMS microbiology reviews
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更新日期：2007-01-01 00:00:00
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更新日期：2010-07-01 00:00:00
