Common patterns - unique features: nitrogen metabolism and regulation in Gram-positive bacteria.

Abstract:

:Gram-positive bacteria have developed elaborate mechanisms to control ammonium assimilation, at the levels of both transcription and enzyme activity. In this review, the common and specific mechanisms of nitrogen assimilation and regulation in Gram-positive bacteria are summarized and compared for the genera Bacillus, Clostridium, Streptomyces, Mycobacterium and Corynebacterium, with emphasis on the high G+C genera. Furthermore, the importance of nitrogen metabolism and control for the pathogenic lifestyle and virulence is discussed. In summary, the regulation of nitrogen metabolism in prokaryotes shows an impressive diversity. Virtually every phylum of bacteria evolved its own strategy to react to the changing conditions of nitrogen supply. Not only do the transcription factors differ between the phyla and sometimes even between families, but the genetic targets of a given regulon can also differ between closely related species.

journal_name

FEMS Microbiol Rev

authors

Amon J,Titgemeyer F,Burkovski A

doi

10.1111/j.1574-6976.2010.00216.x

subject

Has Abstract

pub_date

2010-07-01 00:00:00

pages

588-605

issue

4

eissn

0168-6445

issn

1574-6976

pii

FMR216

journal_volume

34

pub_type

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