abstract：:Wall teichoic acids (WTAs) are charged glycopolymers containing phosphodiester-linked polyol units and represent one of the major components of Gram-positive cell envelope. WTAs have important physiological functions in cell division, gene transfer, surface adhesion, drug resistance, and biofilm formation, and are cri...

journal_title：FEMS microbiology reviews

authors： Wu X,Han J,Gong G,Koffas MAG,Zha J

更新日期：2020-12-03 00:00:00

abstract：:Stress responses are crucial for bacteria to survive harmful conditions that they encounter in the environment. Although gene regulatory mechanisms underlying stress responses in bacteria have been thoroughly characterised for decades, recent advances in imaging technologies helped to uncover previously hidden dynamic...

journal_title：FEMS microbiology reviews

authors： Lagage V,Uphoff S

更新日期：2020-09-01 00:00:00

abstract：:A close symbiotic relationship exists between the intestinal microbiota and its host. A critical component of gut homeostasis is the presence of a mucus layer covering the gastrointestinal tract. Mucus is a viscoelastic gel at the interface between the luminal content and the host tissue that provides a habitat to the...

journal_title：FEMS microbiology reviews

authors： Etienne-Mesmin L,Chassaing B,Desvaux M,De Paepe K,Gresse R,Sauvaitre T,Forano E,de Wiele TV,Schüller S,Juge N,Blanquet-Diot S

更新日期：2019-09-01 00:00:00

abstract：:The herbivore rumen ecosystem constitutes an extremely efficient degradation machinery for the intricate chemical structure of fiber biomass, thus, enabling the hosting animal to digest its feed. The challenging task of deconstructing and metabolizing fiber is performed by microorganisms inhabiting the rumen. Since mo...

journal_title：FEMS microbiology reviews

authors： Moraïs S,Mizrahi I

更新日期：2019-07-01 00:00:00

abstract：:Understanding the structure, functionalities and biology of functional amyloids is an issue of emerging interest. Inclusion bodies, namely protein clusters formed in recombinant bacteria during protein production processes, have emerged as unanticipated, highly tunable models for the scrutiny of the physiology and arc...

journal_title：FEMS microbiology reviews

authors： de Marco A,Ferrer-Miralles N,Garcia-Fruitós E,Mitraki A,Peternel S,Rinas U,Trujillo-Roldán MA,Valdez-Cruz NA,Vázquez E,Villaverde A

更新日期：2019-01-01 00:00:00

abstract：:Microbial networks are an increasingly popular tool to investigate microbial community structure, as they integrate multiple types of information and may represent systems-level behaviour. Interpreting these networks is not straightforward, and the biological implications of network properties are unclear. Analysis of...

journal_title：FEMS microbiology reviews

authors： Röttjers L,Faust K

更新日期：2018-11-01 00:00:00

abstract：:Bacillus thuringiensis is a well-known biopesticide that has been used for more than 80 years. This spore-forming bacterium belongs to the group of Bacillus cereus that also includes, among others, emetic and diarrheic pathotypes of B. cereus, the animal pathogen Bacillus anthracis and the psychrotolerant Bacillus wei...

journal_title：FEMS microbiology reviews

authors： Gillis A,Fayad N,Makart L,Bolotin A,Sorokin A,Kallassy M,Mahillon J

更新日期：2018-11-01 00:00:00

abstract：:Cell surfaces are critical for diverse functions across all domains of life, from cell-cell communication and nutrient uptake to cell stability and surface attachment. While certain aspects of the mechanisms supporting the biosynthesis of the archaeal cell surface are unique, likely due to important differences in cel...

journal_title：FEMS microbiology reviews

authors： Pohlschroder M,Pfeiffer F,Schulze S,Abdul Halim MF

更新日期：2018-09-01 00:00:00

abstract：:Antibiotics are the most common type of medication prescribed to children, including infants, in the Western world. While use of antibiotics has transformed previously lethal infections into relatively minor diseases, antibiotic treatments can have adverse effects as well. It has been shown in children, adults and ani...

journal_title：FEMS microbiology reviews

authors： Neuman H,Forsythe P,Uzan A,Avni O,Koren O

更新日期：2018-07-01 00:00:00

abstract：:Phenotypically heterogeneous microenvironments emerge as biofilms mature across different environments. Phenotypic heterogeneity in biofilm sub-populations not obeying quorum sensing-dictated, collective group behavior may be considered as a strategy allowing non-conformists to survive hostile conditions. Heterogeneou...

journal_title：FEMS microbiology reviews

authors： Ren Y,Wang C,Chen Z,Allan E,van der Mei HC,Busscher HJ

更新日期：2018-05-01 00:00:00

abstract：:Protists include all eukaryotes except plants, fungi and animals. They are an essential, yet often forgotten, component of the soil microbiome. Method developments have now furthered our understanding of the real taxonomic and functional diversity of soil protists. They occupy key roles in microbial foodwebs as consum...

journal_title：FEMS microbiology reviews

authors： Geisen S,Mitchell EAD,Adl S,Bonkowski M,Dunthorn M,Ekelund F,Fernández LD,Jousset A,Krashevska V,Singer D,Spiegel FW,Walochnik J,Lara E

更新日期：2018-05-01 00:00:00

abstract：:Human protein kinase C (PKC) isoforms have been implicated in diseases such as Alzheimer's, diabetes and cancers. In contrast to mammals, which have at least nine genes, fungi have only one or two. The yeast Saccharomyces cerevisiae produces only a single Pkc1 and is employed in the study of specific human isozymes, i...

journal_title：FEMS microbiology reviews

authors： Heinisch JJ,Rodicio R

更新日期：2018-01-01 00:00:00

abstract：:The natural light environment is important to many prokaryotes. Most obviously, phototrophic prokaryotes need to acclimate their photosynthetic apparatus to the prevailing light conditions, and such acclimation is frequently complemented by motility to enable cells to relocate in search of more favorable illumination ...

journal_title：FEMS microbiology reviews

authors： Wilde A,Mullineaux CW

更新日期：2017-11-01 00:00:00

abstract：:Five species of parasite cause malaria in humans with the most severe disease caused by Plasmodium falciparum. Many of the proteins encoded in the P. falciparum genome are unusually enriched in repetitive low-complexity sequences containing a limited repertoire of amino acids. These repetitive sequences expand and con...

journal_title：FEMS microbiology reviews

authors： Davies HM,Nofal SD,McLaughlin EJ,Osborne AR

更新日期：2017-11-01 00:00:00

abstract：:First insights on the human gut microbiome have been gained from medium-sized, cross-sectional studies. However, given the modest portion of explained variance of currently identified covariates and the small effect size of gut microbiota modulation strategies, upscaling seems essential for further discovery and chara...

journal_title：FEMS microbiology reviews

authors： Vandeputte D,Tito RY,Vanleeuwen R,Falony G,Raes J

更新日期：2017-08-01 00:00:00

abstract：:Deeper sequencing and improved bioinformatics in conjunction with single-cell and metagenomic approaches continue to illuminate undercharacterized environmental microbial communities. This has propelled the 'who is there, and what might they be doing' paradigm to the uncultivated and has already radically changed the ...

journal_title：FEMS microbiology reviews

authors： Doud DFR,Woyke T

更新日期：2017-07-01 00:00:00

abstract：:Antibiotic resistance can be acquired by mutation or horizontal transfer of a resistance gene, and generally an acquired mechanism results in a predictable increase in phenotypic resistance. However, recent findings suggest that the environment and/or the genetic context can modify the phenotypic expression of specifi...

journal_title：FEMS microbiology reviews

authors： Hughes D,Andersson DI

更新日期：2017-05-01 00:00:00

abstract：:Toxin-antitoxin systems (TAs) are ubiquitous among bacteria and play a crucial role in the dissemination and evolution of antibiotic resistance, such as maintaining multi-resistant plasmids and inducing persistence formation. Generally, activities of the toxins are neutralised by their conjugate antitoxins. In contras...

journal_title：FEMS microbiology reviews

authors： Yang QE,Walsh TR

更新日期：2017-05-01 00:00:00

abstract：:The spread of antibiotic resistance and increasing prevalence of biofilm-associated infections is driving demand for new means to treat bacterial infection. Nanotechnology provides an innovative platform for addressing this challenge, with potential to manage even infections involving multidrug-resistant (MDR) bacteri...

journal_title：FEMS microbiology reviews

authors： Natan M,Banin E

更新日期：2017-05-01 00:00:00

abstract：:Dysfunction of phagocytes is a relevant risk factor for staphylococcal infection. The most common hereditary phagocyte dysfunction is chronic granulomatous disease (CGD), characterized by impaired generation of reactive oxygen species (ROS) due to loss of function mutations within the phagocyte NADPH oxidase NOX2. Pha...

journal_title：FEMS microbiology reviews

authors： Buvelot H,Posfay-Barbe KM,Linder P,Schrenzel J,Krause KH

更新日期：2017-03-01 00:00:00

abstract：:O-antigen polysaccharide is a major immunogenic feature of the lipopolysaccharide of Gram-negative bacteria, and most species produce a large variety of forms that differ substantially from one another. There are 18 known O-antigen forms in the Yersinia pseudotuberculosis complex, which are typical in being composed o...

journal_title：FEMS microbiology reviews

authors： Kenyon JJ,Cunneen MM,Reeves PR

更新日期：2017-03-01 00:00:00

abstract：:The bacterium Chlamydia trachomatis is the etiological agent of the most common sexually transmitted infection in North America and Europe. Medical complications resulting from genital C. trachomatis infections arise predominantly in women where the initial infections often remain asymptomatic and thus unrecognized. U...

journal_title：FEMS microbiology reviews

authors： Finethy R,Coers J

更新日期：2016-11-01 00:00:00

abstract：:In the present review, we aim to provide a general introduction to different facets of the arms race between pathogens and their hosts/environment, emphasizing its evolutionary aspects. We focus on vector-borne parasitic protozoa, which have to adapt to both invertebrate and vertebrate hosts. Using Leishmania, Trypano...

journal_title：FEMS microbiology reviews

authors： Caljon G,De Muylder G,Durnez L,Jennes W,Vanaerschot M,Dujardin JC

更新日期：2016-09-01 00:00:00

abstract：:Targeted manipulation of the gut flora is increasingly being recognized as a means to improve human health. Yet, the temporal dynamics and intra- and interindividual heterogeneity of the microbiome represent experimental limitations, especially in human cross-sectional studies. Therefore, rodent models represent an in...

journal_title：FEMS microbiology reviews

authors： Laukens D,Brinkman BM,Raes J,De Vos M,Vandenabeele P

更新日期：2016-01-01 00:00:00

abstract：:Bacteria possess a repertoire of versatile protein kinases modulating diverse aspects of their physiology by phosphorylating proteins on various amino acids including histidine, cysteine, aspartic acid, arginine, serine, threonine and tyrosine. One class of membrane serine/threonine protein kinases possesses a catalyt...

journal_title：FEMS microbiology reviews

authors： Manuse S,Fleurie A,Zucchini L,Lesterlin C,Grangeasse C

更新日期：2016-01-01 00:00:00

abstract：:More than a century ago, the term 'virus' was introduced to describe infectious agents that are invisible by light microscopy and capable of passing through sterilizing filters. In addition to their extremely small size, most viruses have minimal genomes and gene contents, and rely almost entirely on host cell-encoded...

journal_title：FEMS microbiology reviews

authors： Abergel C,Legendre M,Claverie JM

更新日期：2015-11-01 00:00:00

abstract：:What a living organism looks like and how it works and what are its components-all this is encoded on DNA, the genetic blueprint. Consequently, the way to change an organism is to change its genetic information. Since the first pieces of recombinant DNA have been used to transform cells in the 1970s, this approach has...

journal_title：FEMS microbiology reviews

authors： Schindler D,Waldminghaus T

更新日期：2015-11-01 00:00:00

abstract：:Lack of known mechanisms of protection against Staphylococcus aureus in humans is hindering development of efficacious vaccines. Preclinical as well as clinical data suggest that antibodies play an important role against S. aureus. For instance, certain hypogammaglobulinaemic patients are at increased risk of staphylo...

journal_title：FEMS microbiology reviews

authors： Pozzi C,Lofano G,Mancini F,Soldaini E,Speziale P,De Gregorio E,Rappuoli R,Bertholet S,Grandi G,Bagnoli F

更新日期：2015-09-01 00:00:00

abstract：:Type II (proteic) toxin-antitoxin (TA) operons are widely spread in bacteria and archaea. They are organized as operons in which, usually, the antitoxin gene precedes the cognate toxin gene. The antitoxin generally acts as a transcriptional self-repressor, whereas the toxin acts as a co-repressor, both proteins consti...

journal_title：FEMS microbiology reviews

authors： Chan WT,Balsa D,Espinosa M

更新日期：2015-07-01 00:00:00

abstract：:Sequencing-based studies have illuminated increased transcriptional complexity within the genome structure of bacteria and have resulted in the identification of many small regulatory RNAs (sRNA) and a large amount of antisense transcription. It remains an open question whether these sRNAs all indeed play regulatory r...

journal_title：FEMS microbiology reviews

authors： Oliva G,Sahr T,Buchrieser C

更新日期：2015-05-01 00:00:00

abstract：:The increasing numbers of characterized base-pairing small RNAs (sRNAs) and the identification of these regulators in a broad range of bacteria are allowing comparisons between species and explorations of sRNA evolution. In this review, we describe some examples of trans-encoded base-pairing sRNAs that are species-spe...

journal_title：FEMS microbiology reviews

authors： Updegrove TB,Shabalina SA,Storz G

更新日期：2015-05-01 00:00:00

abstract：:Dengue is the most prevalent arthropod-borne viral disease, caused by dengue virus, a member of the Flaviviridae family. Its worldwide incidence is now a major health problem, with 2.5 billion people living in risk areas. In this review, we integrate the structural rearrangements of each viral protein and their functi...

journal_title：FEMS microbiology reviews

authors： Cruz-Oliveira C,Freire JM,Conceição TM,Higa LM,Castanho MA,Da Poian AT

更新日期：2015-03-01 00:00:00

abstract：:The genus Rickettsia (Alphaproteobacteria, Rickettsiales, Rickettsiaceae) is comprised of obligate intracellular parasites, with virulent species of interest both as causes of emerging infectious diseases and for their potential deployment as bioterrorism agents. Currently, there are no effective commercially availabl...

journal_title：FEMS microbiology reviews

authors： Gillespie JJ,Kaur SJ,Rahman MS,Rennoll-Bankert K,Sears KT,Beier-Sexton M,Azad AF

更新日期：2015-01-01 00:00:00

abstract：:Metals are required cofactors for numerous fundamental processes that are essential to both pathogen and host. They are coordinated in enzymes responsible for DNA replication and transcription, relief from oxidative stress, and cellular respiration. However, excess transition metals can be toxic due to their ability t...

journal_title：FEMS microbiology reviews

authors： Becker KW,Skaar EP

更新日期：2014-11-01 00:00:00

abstract：:Water is one of the most important bacterial habitats on Earth. As such, water represents also a major way of dissemination of bacteria between different environmental compartments. Human activities led to the creation of the so-called urban water cycle, comprising different sectors (waste, surface, drinking water), a...

journal_title：FEMS microbiology reviews

authors： Vaz-Moreira I,Nunes OC,Manaia CM

更新日期：2014-07-01 00:00:00

abstract：:The yeast Saccharomyces cerevisiae has been a favorite organism for pioneering studies on nutrient-sensing and signaling mechanisms. Many specific nutrient responses have been elucidated in great detail. This has led to important new concepts and insight into nutrient-controlled cellular regulation. Major highlights i...

journal_title：FEMS microbiology reviews

authors： Conrad M,Schothorst J,Kankipati HN,Van Zeebroeck G,Rubio-Texeira M,Thevelein JM

更新日期：2014-03-01 00:00:00

abstract：:The urogenital tract appears to be the only niche of the human body that shows clear differences in microbiota between men and women. The female reproductive tract has special features in terms of immunological organization, an epithelial barrier, microbiota, and influence by sex hormones such as estrogen. While the u...

journal_title：FEMS microbiology reviews

authors： Petrova MI,van den Broek M,Balzarini J,Vanderleyden J,Lebeer S

更新日期：2013-09-01 00:00:00

abstract：:Interest in the expanding catalog of uncultivated microorganisms, increasing recognition of heterogeneity among seemingly similar cells, and technological advances in whole-genome amplification and single-cell manipulation are driving considerable progress in single-cell genomics. Here, the spectrum of applications fo...

journal_title：FEMS microbiology reviews

authors： Blainey PC

更新日期：2013-05-01 00:00:00

abstract：:The P(II) proteins are one of the most widely distributed families of signal transduction proteins in nature. They are pivotal players in the control of nitrogen metabolism in bacteria and archaea, and are also found in the plastids of plants. Quite remarkably, P(II) proteins control the activities of a diverse rang...

journal_title：FEMS microbiology reviews

authors： Huergo LF,Chandra G,Merrick M

更新日期：2013-03-01 00:00:00

abstract：:Our knowledge regarding the nature and development of microbial biofilms has grown significantly since the first report of these communities by Antonie van Leeuwenhoek in the late 1600s. Nevertheless, most biofilm studies examine mono-species cultures, whereas nearly all biofilm communities in nature comprise a variet...

journal_title：FEMS microbiology reviews

authors： Elias S,Banin E

更新日期：2012-09-01 00:00:00