Abstract:
:Glucuronide and sulfate conjugation are important pathways in the peripheral metabolism of thyroid hormone. These reactions occur predominantly in the liver, and especially the glucuronides are excreted in the bile. Although an enterohepatic circulation after intestinal hydrolysis of iodothyronine conjugates is suggested by several authors, substantial proof has not been presented so far. In the present paper experimental work from our group is reviewed. The studies showed that fecal suspensions of human or rat origin hydrolysed iodothyronine conjugates, whereas oral administration of antibiotics to rats strongly reduced this capacity. Obligately anaerobic intestinal bacteria were found to be responsible for the hydrolysis and several species belonging to the major residents of the intestinal flora of man and rat could be isolated and identified. Recent studies with conventional and decontaminated rats produced strong support for the existence of an enterohepatic circulation of thyroid hormone. Our findings are discussed in connection with other relevant studies on this subject.
journal_name
FEMS Microbiol Revjournal_title
FEMS microbiology reviewsauthors
Hazenberg MP,de Herder WW,Visser TJdoi
10.1111/j.1574-6968.1988.tb02709.x-i1subject
Has Abstractpub_date
1988-02-01 00:00:00pages
9-16issue
1eissn
0168-6445issn
1574-6976journal_volume
4pub_type
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journal_title:FEMS microbiology reviews
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journal_title:FEMS microbiology reviews
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pub_type: 杂志文章,评审
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更新日期:2010-07-01 00:00:00
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journal_title:FEMS microbiology reviews
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更新日期:1995-08-01 00:00:00
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journal_title:FEMS microbiology reviews
pub_type: 杂志文章,评审
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更新日期:2014-07-01 00:00:00
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更新日期:2016-01-01 00:00:00
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journal_title:FEMS microbiology reviews
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