Experimental models to study intestinal microbes-mucus interactions in health and disease.

abstract：:Cell surfaces are critical for diverse functions across all domains of life, from cell-cell communication and nutrient uptake to cell stability and surface attachment. While certain aspects of the mechanisms supporting the biosynthesis of the archaeal cell surface are unique, likely due to important differences in cel...

journal_title：FEMS microbiology reviews

authors： Pohlschroder M,Pfeiffer F,Schulze S,Abdul Halim MF

更新日期：2018-09-01 00:00:00

abstract：:Meningococcal disease is a serious and rapidly progressing illness. It is therefore very important to monitor changes in the level of antibiotic susceptibility among clinical isolates. Different aspects such as interpretation of laboratory results, determination of breakpoints predicting treatment failure as well as d...

journal_title：FEMS microbiology reviews

authors： Vázquez JA,Enriquez R,Abad R,Alcalá B,Salcedo C,Arreaza L

更新日期：2007-01-01 00:00:00

abstract：:The accurate synthesis of proteins, dictated by the corresponding nucleotide sequence encoded in mRNA, is essential for cell growth and survival. Central to this process are the aminoacyl-tRNA synthetases (aaRSs), which provide amino acid substrates for the growing polypeptide chain in the form of aminoacyl-tRNAs. The...

journal_title：FEMS microbiology reviews

authors： Hausmann CD,Ibba M

更新日期：2008-07-01 00:00:00

abstract：:Metals are required cofactors for numerous fundamental processes that are essential to both pathogen and host. They are coordinated in enzymes responsible for DNA replication and transcription, relief from oxidative stress, and cellular respiration. However, excess transition metals can be toxic due to their ability t...

journal_title：FEMS microbiology reviews

authors： Becker KW,Skaar EP

更新日期：2014-11-01 00:00:00

abstract：:Toxin-antitoxin systems (TAs) are ubiquitous among bacteria and play a crucial role in the dissemination and evolution of antibiotic resistance, such as maintaining multi-resistant plasmids and inducing persistence formation. Generally, activities of the toxins are neutralised by their conjugate antitoxins. In contras...

journal_title：FEMS microbiology reviews

authors： Yang QE,Walsh TR

更新日期：2017-05-01 00:00:00

abstract：:Bacteria of the genus Brucella are Gram-negative pathogens of several animal species that cause a zoonotic disease in humans known as brucellosis or Malta fever. Within their hosts, brucellae reside within different cell types where they establish a replicative niche and remain protected from the immune response. The ...

journal_title：FEMS microbiology reviews

authors： von Bargen K,Gorvel JP,Salcedo SP

更新日期：2012-05-01 00:00:00

abstract：:Antibiotic resistance mechanisms reported in Gram-negative bacteria are causing a worldwide health problem. The continuous dissemination of 'multidrug-resistant' (MDR) bacteria drastically reduces the efficacy of our antibiotic 'arsenal' and consequently increases the frequency of therapeutic failure. In MDR bacteria,...

journal_title：FEMS microbiology reviews

authors： Nikaido H,Pagès JM

更新日期：2012-03-01 00:00:00

abstract：:Based on structural, biochemical, and genetic data, the soluble diiron monooxygenases can be divided into four groups: the soluble methane monooxygenases, the Amo alkene monooxygenase of Rhodococcus corallinus B-276, the phenol hydroxylases, and the four-component alkene/aromatic monooxygenases. The limited phylogenet...

journal_title：FEMS microbiology reviews

authors： Leahy JG,Batchelor PJ,Morcomb SM

更新日期：2003-10-01 00:00:00

abstract：:Human enteric pathogenic viruses can enter the environment through discharge of waste materials from infected persons, and be transmitted back to susceptible persons to continue the cycle of disease. Contamination of food with viruses may also promote disease outbreaks. A number of studies have investigated the surviv...

journal_title：FEMS microbiology reviews

authors： Rzezutka A,Cook N

更新日期：2004-10-01 00:00:00

abstract：:DNA microarrays are a powerful and promising approach to gain a detailed understanding of the bacterial response and the molecular cross-talk that can occur as a consequence of host-pathogen interactions. However, published studies mainly describe the host response to infection. Analysis of bacterial gene regulation i...

journal_title：FEMS microbiology reviews

authors： La MV,Raoult D,Renesto P

更新日期：2008-05-01 00:00:00

abstract：:Arsenic compounds have been abundant at near toxic levels in the environment since the origin of life. In response, microbes have evolved mechanisms for arsenic resistance and enzymes that oxidize As(III) to As(V) or reduce As(V) to As(III). Formation and degradation of organoarsenicals, for example methylarsenic comp...

journal_title：FEMS microbiology reviews

authors： Mukhopadhyay R,Rosen BP,Phung LT,Silver S

更新日期：2002-08-01 00:00:00

abstract：:Invasive bacterial pathogens intervene at various stages and by various mechanisms with the mammalian plasminogen/plasmin system. A vast number of pathogens express plasmin(ogen) receptors that immobilize plasmin(ogen) on the bacterial surface, an event that enhances activation of plasminogen by mammalian plasminogen ...

journal_title：FEMS microbiology reviews

authors： Lähteenmäki K,Kuusela P,Korhonen TK

更新日期：2001-12-01 00:00:00

abstract：:Host-adapted strains of Salmonella enterica cause systemic infections and have the ability to persist systemically for long periods of time and pose significant public-health problems. Multidrug-resistant S. enterica serovar Typhi (S. Typhi) and nontyphoidal Salmonella (NTS) are on the increase and are often associate...

journal_title：FEMS microbiology reviews

authors： Ruby T,McLaughlin L,Gopinath S,Monack D

更新日期：2012-05-01 00:00:00

abstract：:A number of peptidases and proteases have been identified in Escherichia coli. Although their specific physiological roles are often not known, some of them have been shown to be involved in: the maturation of nascent polypeptide chains; the maturation of protein precursors; the signal peptide processing of exported p...

journal_title：FEMS microbiology reviews

authors： Lazdunski AM

更新日期：1989-09-01 00:00:00

abstract：:Nickel is an essential nutrient for selected microorganisms where it participates in a variety of cellular processes. Many microbes are capable of sensing cellular nickel ion concentrations and taking up this nutrient via nickel-specific permeases or ATP-binding cassette-type transport systems. The metal ion is specif...

journal_title：FEMS microbiology reviews

authors： Mulrooney SB,Hausinger RP

更新日期：2003-06-01 00:00:00

abstract：:Respiratory syncytial virus is the major respiratory pathogen of infants and children worldwide, with no effective treatment or vaccine available. Steady progress has been made in understanding the respiratory syncytial virus life cycle and the consequences of infection, but many areas of respiratory syncytial virus b...

journal_title：FEMS microbiology reviews

authors： Ghildyal R,Ho A,Jans DA

更新日期：2006-09-01 00:00:00

abstract：:Microbial networks are an increasingly popular tool to investigate microbial community structure, as they integrate multiple types of information and may represent systems-level behaviour. Interpreting these networks is not straightforward, and the biological implications of network properties are unclear. Analysis of...

journal_title：FEMS microbiology reviews

authors： Röttjers L,Faust K

更新日期：2018-11-01 00:00:00

abstract：:Bacteria possess a repertoire of versatile protein kinases modulating diverse aspects of their physiology by phosphorylating proteins on various amino acids including histidine, cysteine, aspartic acid, arginine, serine, threonine and tyrosine. One class of membrane serine/threonine protein kinases possesses a catalyt...

journal_title：FEMS microbiology reviews

authors： Manuse S,Fleurie A,Zucchini L,Lesterlin C,Grangeasse C

更新日期：2016-01-01 00:00:00

abstract：:In the last decade, a variety of ribosomally synthesized antimicrobial peptides or bacteriocins produced by lactic acid bacteria have been identified and characterized. As a result of these studies, insight has been gained into fundamental aspects of biology and biochemistry such as producer self protection, membrane-...

journal_title：FEMS microbiology reviews

authors： Ennahar S,Sashihara T,Sonomoto K,Ishizaki A

更新日期：2000-01-01 00:00:00

abstract：:The bacterium Chlamydia trachomatis is the etiological agent of the most common sexually transmitted infection in North America and Europe. Medical complications resulting from genital C. trachomatis infections arise predominantly in women where the initial infections often remain asymptomatic and thus unrecognized. U...

journal_title：FEMS microbiology reviews

authors： Finethy R,Coers J

更新日期：2016-11-01 00:00:00

abstract：:Lack of known mechanisms of protection against Staphylococcus aureus in humans is hindering development of efficacious vaccines. Preclinical as well as clinical data suggest that antibodies play an important role against S. aureus. For instance, certain hypogammaglobulinaemic patients are at increased risk of staphylo...

journal_title：FEMS microbiology reviews

authors： Pozzi C,Lofano G,Mancini F,Soldaini E,Speziale P,De Gregorio E,Rappuoli R,Bertholet S,Grandi G,Bagnoli F

更新日期：2015-09-01 00:00:00

abstract：:The wealth of information existing on the general principle of S-layers has revealed a broad application potential. The most relevant features exploited in applied S-layer research are: (i) pores passing through S-layers show identical size and morphology and are in the range of ultrafiltration membranes; (ii) functio...

journal_title：FEMS microbiology reviews

authors： Sleytr UB,Bayley H,Sára M,Breitwieser A,Küpcü S,Mader C,Weigert S,Unger FM,Messner P,Jahn-Schmid B,Schuster B,Pum D,Douglas K,Clark NA,Moore JT,Winningham TA,Levy S,Frithsen I,Pankovc J,Beale P,Gillis HP,Choutov

更新日期：1997-06-01 00:00:00

abstract：:In the present review, we aim to provide a general introduction to different facets of the arms race between pathogens and their hosts/environment, emphasizing its evolutionary aspects. We focus on vector-borne parasitic protozoa, which have to adapt to both invertebrate and vertebrate hosts. Using Leishmania, Trypano...

journal_title：FEMS microbiology reviews

authors： Caljon G,De Muylder G,Durnez L,Jennes W,Vanaerschot M,Dujardin JC

更新日期：2016-09-01 00:00:00

abstract：:Enterohaemorrhagic Escherichia coli O157:H7 was first implicated in human disease in the early 1980s, with ruminants cited as the primary reservoirs. Preliminary studies indicated cattle to be the sole source of E. coli O157:H7 outbreaks in humans; however, further epidemiological studies soon demonstrated that E. col...

journal_title：FEMS microbiology reviews

authors： La Ragione RM,Best A,Woodward MJ,Wales AD

更新日期：2009-03-01 00:00:00

abstract：:Cyanobacteria of the genera Synechococcus and Prochlorococcus dominate the prokaryotic component of the picophytoplankton in the oceans. It is still less than 10 years since the discovery of phages that infect marine Synechococcus and the beginning of the characterisation of these phages and assessment of their ecolog...

journal_title：FEMS microbiology reviews

authors： Mann NH

更新日期：2003-04-01 00:00:00

abstract：:The head assembly pathway of bacteriophage HK97 shares many features with head assembly pathways determined for other dsDNA phages, and it also provides examples of novel variations on the basic theme. We describe aspects of two specific steps in the assembly pathway, the covalent cross-linking among the assembled hea...

journal_title：FEMS microbiology reviews

authors： Duda RL,Martincic K,Xie Z,Hendrix RW

更新日期：1995-08-01 00:00:00

abstract：:Pseudomonas putida is a gram-negative rod-shaped gammaproteobacterium that is found throughout various environments. Members of the species P. putida show a diverse spectrum of metabolic activities, which is indicative of their adaptation to various niches, which includes the ability to live in soils and sediments con...

journal_title：FEMS microbiology reviews

authors： Wu X,Monchy S,Taghavi S,Zhu W,Ramos J,van der Lelie D

更新日期：2011-03-01 00:00:00

abstract：:The initial step of methanogenesis from CO2 is the formation of formyl-methanofuran (formyl-MFR) from methanofuran (MFR), CO2 and H2. The enzymology of this novel type of CO2 fixation reaction has been difficult to study because formyl-MFR synthesis is subject to a complex activation. Recently, however, a number of ad...

journal_title：FEMS microbiology reviews

authors： Bobik TA,DiMarco AA,Wolfe RS

更新日期：1990-12-01 00:00:00

abstract：:Type II (proteic) toxin-antitoxin (TA) operons are widely spread in bacteria and archaea. They are organized as operons in which, usually, the antitoxin gene precedes the cognate toxin gene. The antitoxin generally acts as a transcriptional self-repressor, whereas the toxin acts as a co-repressor, both proteins consti...

journal_title：FEMS microbiology reviews

authors： Chan WT,Balsa D,Espinosa M

更新日期：2015-07-01 00:00:00

abstract：:Antibiotic resistance can be acquired by mutation or horizontal transfer of a resistance gene, and generally an acquired mechanism results in a predictable increase in phenotypic resistance. However, recent findings suggest that the environment and/or the genetic context can modify the phenotypic expression of specifi...

journal_title：FEMS microbiology reviews

authors： Hughes D,Andersson DI

更新日期：2017-05-01 00:00:00