Abstract:
:Meningococcal disease is a serious and rapidly progressing illness. It is therefore very important to monitor changes in the level of antibiotic susceptibility among clinical isolates. Different aspects such as interpretation of laboratory results, determination of breakpoints predicting treatment failure as well as definition of susceptibility levels in clinical samples using molecular methods are critical points for the surveillance of antibiotic resistance in Neisseria meningitidis. Within the strategic framework outlined by the EU.MenNet project, several objectives were identified to analyze 'The spread of antibiotic resistant meningococci in Europe', including the extent of antimicrobial resistance, its association with particular meningococcal lineages and geographical areas, as well as molecular characterization of the mechanisms involved, particularly in penicillin resistance. A heterogeneous figure for the frequency of intermediate resistance to penicillin appears across Europe. This heterogeneity may reflect different clonal lineages and/or uneven access to antibiotics in each country. In addition, the use of different criteria for the methodology used for definition cannot be avoided. The description of five specific changes associated with intermediate resistance to penicillin also allows the design of PCR-based tools to objectify results and for application in clinical samples.
journal_name
FEMS Microbiol Revjournal_title
FEMS microbiology reviewsauthors
Vázquez JA,Enriquez R,Abad R,Alcalá B,Salcedo C,Arreaza Ldoi
10.1111/j.1574-6976.2006.00049.xsubject
Has Abstractpub_date
2007-01-01 00:00:00pages
64-70issue
1eissn
0168-6445issn
1574-6976pii
FMR049journal_volume
31pub_type
杂志文章,评审abstract::Small regulatory RNAs have been identified in a wide range of organisms, where they modify mRNA stability, translation or protein function. Small RNA regulators (sRNAs) either pair with mRNA targets or modify protein activities. Here we discuss current knowledge of the various proteins that interact with RNA regulator...
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journal_title:FEMS microbiology reviews
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journal_title:FEMS microbiology reviews
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journal_title:FEMS microbiology reviews
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journal_title:FEMS microbiology reviews
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更新日期:1990-12-01 00:00:00
abstract::Gene conversion is defined as the non-reciprocal transfer of information between homologous sequences. Despite methodological problems to establish non-reciprocity, gene conversion has been demonstrated in a wide variety of bacteria. Besides examples of high-frequency reversion of mutations in repeated genes, gene con...
journal_title:FEMS microbiology reviews
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更新日期:2010-07-01 00:00:00
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journal_title:FEMS microbiology reviews
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