Quorum-sensing in Gram-negative bacteria.

Abstract:

:It has become increasingly and widely recognised that bacteria do not exist as solitary cells, but are colonial organisms that exploit elaborate systems of intercellular communication to facilitate their adaptation to changing environmental conditions. The languages by which bacteria communicate take the form of chemical signals, excreted from the cells, which can elicit profound physiological changes. Many types of signalling molecules, which regulate diverse phenotypes across distant genera, have been described. The most common signalling molecules found in Gram-negative bacteria are N-acyl derivatives of homoserine lactone (acyl HSLs). Modulation of the physiological processes controlled by acyl HSLs (and, indeed, many of the non-acyl HSL-mediated systems) occurs in a cell density- and growth phase-dependent manner. Therefore, the term 'quorum-sensing' has been coined to describe this ability of bacteria to monitor cell density before expressing a phenotype. In this paper, we review the current state of research concerning acyl HSL-mediated quorum-sensing. We also describe two non-acyl HSL-based systems utilised by the phytopathogens Ralstonia solanacearum and Xanthomonas campestris.

journal_name

FEMS Microbiol Rev

authors

Whitehead NA,Barnard AM,Slater H,Simpson NJ,Salmond GP

doi

10.1111/j.1574-6976.2001.tb00583.x

subject

Has Abstract

pub_date

2001-08-01 00:00:00

pages

365-404

issue

4

eissn

0168-6445

issn

1574-6976

pii

S0168-6445(01)00059-6

journal_volume

25

pub_type

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