Abstract：
:Natural genetic transformation is widely distributed in bacteria. It is a genetically programmed process that is inherent to the species. Transformation requires a specialized membrane-associated machinery for uptake of exogenous double-stranded DNA. It also requires dedicated cytosolic proteins, some of which have been characterized only recently, for the processing of internalized single-stranded DNA fragments into recombination products. A series of observations made in Bacillus subtilis and Streptococcus pneumoniae led to the recent emergence of a picture of a unique, highly integrated machine localized at the cell poles. This dynamic machine, which we propose to name the transformasome, involves both membrane and cytosolic proteins, to internalize, protect, and process transforming DNA. This review attempts to summarize these recent observations with special emphasis on the early stages in DNA processing.
journal_name
FEMS Microbiol Revjournal_title
FEMS microbiology reviewsauthors
Claverys JP,Martin B,Polard Pdoi
10.1111/j.1574-6976.2009.00164.xsubject
Has Abstractpub_date
2009-05-01 00:00:00pages
643-56issue
3eissn
0168-6445issn
1574-6976pii
FMR164journal_volume
33pub_type
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journal_title：FEMS microbiology reviews
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journal_title：FEMS microbiology reviews
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journal_title：FEMS microbiology reviews
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journal_title：FEMS microbiology reviews
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journal_title：FEMS microbiology reviews
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journal_title：FEMS microbiology reviews
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journal_title：FEMS microbiology reviews
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journal_title：FEMS microbiology reviews
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pub_type： 杂志文章,评审
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journal_title：FEMS microbiology reviews
pub_type： 杂志文章,评审
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更新日期：2017-05-01 00:00:00
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journal_title：FEMS microbiology reviews
pub_type： 杂志文章
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更新日期：1994-05-01 00:00:00
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journal_title：FEMS microbiology reviews
pub_type： 杂志文章,评审
doi：10.1016/S0168-6445(03)00042-1
更新日期：2003-06-01 00:00:00
