Abstract:
:Gene regB of bacteriophage T4 encodes a sequence-specific endoribonuclease which introduces cuts in early phage messenger RNAs. In most cases, cutting takes place in the middle of the tetranucleotide GGAG. Efficient cleavages occur in the motifs located in intergenic regions, some of them being Shine-Dalgarno sequences. When located in a coding sequence, this tetranucleotide is poorly recognized or not at all. In this article, we have reviewed the properties of the RegB endoribonuclease, with emphasis on its possible roles in T4 development. We show that the nuclease RegB plays at least two roles: (i) it inactivates a sub-class of early mRNA by cleaving Shine-Dalgarno sequences, and (ii) it is necessary for the degradation of early mRNAs, but not of middle and late mRNAs. Accordingly, we found that middle and late mRNAs avoid processing by RegB, probably for different reasons. Most of the middle mRNAs (mRNAs initiated at MotA-dependent promoters) do not contain the motif GGAG in their intergenic regions, whereas about one-third of the late genes have this motif as Shine-Dalgarno sequence. It is not yet known whether the RNase is inactivated early in the phage cycle, or whether it remains active but cannot recognize late mRNAs as substrates.
journal_name
FEMS Microbiol Revjournal_title
FEMS microbiology reviewsauthors
Sanson B,Uzan Mdoi
10.1111/j.1574-6976.1995.tb00196.xsubject
Has Abstractpub_date
1995-08-01 00:00:00pages
141-50issue
1-2eissn
0168-6445issn
1574-6976pii
0168-6445(94)00075-1journal_volume
17pub_type
杂志文章,评审abstract::DNA microarrays are a powerful and promising approach to gain a detailed understanding of the bacterial response and the molecular cross-talk that can occur as a consequence of host-pathogen interactions. However, published studies mainly describe the host response to infection. Analysis of bacterial gene regulation i...
journal_title:FEMS microbiology reviews
pub_type: 杂志文章,评审
doi:10.1111/j.1574-6976.2008.00103.x
更新日期:2008-05-01 00:00:00
abstract::Cell surfaces are critical for diverse functions across all domains of life, from cell-cell communication and nutrient uptake to cell stability and surface attachment. While certain aspects of the mechanisms supporting the biosynthesis of the archaeal cell surface are unique, likely due to important differences in cel...
journal_title:FEMS microbiology reviews
pub_type: 杂志文章
doi:10.1093/femsre/fuy027
更新日期:2018-09-01 00:00:00
abstract::Meningococcal disease is a serious and rapidly progressing illness. It is therefore very important to monitor changes in the level of antibiotic susceptibility among clinical isolates. Different aspects such as interpretation of laboratory results, determination of breakpoints predicting treatment failure as well as d...
journal_title:FEMS microbiology reviews
pub_type: 杂志文章,评审
doi:10.1111/j.1574-6976.2006.00049.x
更新日期:2007-01-01 00:00:00
abstract::Lack of known mechanisms of protection against Staphylococcus aureus in humans is hindering development of efficacious vaccines. Preclinical as well as clinical data suggest that antibodies play an important role against S. aureus. For instance, certain hypogammaglobulinaemic patients are at increased risk of staphylo...
journal_title:FEMS microbiology reviews
pub_type: 杂志文章,评审
doi:10.1093/femsre/fuv024
更新日期:2015-09-01 00:00:00
abstract::We review and update the work on genetic elements, e.g., viruses and plasmids (exluding IS elements and transposons) in the kingdom Crenarchaeota (Thermoproteales and Sulfolobales) and the orders Thermococcales and Thermoplasmales in the kingdom Euryarchaeota of the archael domain, including unpublished data from our ...
journal_title:FEMS microbiology reviews
pub_type: 杂志文章,评审
doi:10.1111/j.1574-6976.1996.tb00239.x
更新日期:1996-05-01 00:00:00
abstract::This review concerns the issues involved in the industrial development of fed-batch culture processes with Saccharomyces cerevisiae strains producing heterologous proteins. Most of process development considerations with fed-batch recombinant cultures are linked to the reliability and reproducibility of the process fo...
journal_title:FEMS microbiology reviews
pub_type: 杂志文章,评审
doi:10.1111/j.1574-6976.1994.tb00146.x
更新日期:1994-12-01 00:00:00
abstract::A close symbiotic relationship exists between the intestinal microbiota and its host. A critical component of gut homeostasis is the presence of a mucus layer covering the gastrointestinal tract. Mucus is a viscoelastic gel at the interface between the luminal content and the host tissue that provides a habitat to the...
journal_title:FEMS microbiology reviews
pub_type: 杂志文章,评审
doi:10.1093/femsre/fuz013
更新日期:2019-09-01 00:00:00
abstract::Bacteria of the genus Brucella are Gram-negative pathogens of several animal species that cause a zoonotic disease in humans known as brucellosis or Malta fever. Within their hosts, brucellae reside within different cell types where they establish a replicative niche and remain protected from the immune response. The ...
journal_title:FEMS microbiology reviews
pub_type: 杂志文章,评审
doi:10.1111/j.1574-6976.2012.00334.x
更新日期:2012-05-01 00:00:00
abstract::Antibiotic resistance can be acquired by mutation or horizontal transfer of a resistance gene, and generally an acquired mechanism results in a predictable increase in phenotypic resistance. However, recent findings suggest that the environment and/or the genetic context can modify the phenotypic expression of specifi...
journal_title:FEMS microbiology reviews
pub_type: 杂志文章,评审
doi:10.1093/femsre/fux004
更新日期:2017-05-01 00:00:00
abstract::Methanogens form a very large and diverse group of microorganisms within the domain of the Archaea. Energy for their growth is obtained by the reduction of a variety of substrates into methane. Several genes, coding for enzymes involved in methanogenesis or in the central metabolism have been cloned and studied. The m...
journal_title:FEMS microbiology reviews
pub_type: 杂志文章,评审
doi:10.1111/j.1574-6976.1994.tb00138.x
更新日期:1994-10-01 00:00:00
abstract::Understanding the structure, functionalities and biology of functional amyloids is an issue of emerging interest. Inclusion bodies, namely protein clusters formed in recombinant bacteria during protein production processes, have emerged as unanticipated, highly tunable models for the scrutiny of the physiology and arc...
journal_title:FEMS microbiology reviews
pub_type: 杂志文章,评审
doi:10.1093/femsre/fuy038
更新日期:2019-01-01 00:00:00
abstract::Ribonuclease P is the endonuclease required for generating the mature tRNA 5'-end. The ribonucleoprotein character of this enzyme has now been proven in most organisms and organelles. Exceptions, however, are still the chloroplasts, plant nuclei and animal mitochondria where no associated RNAs have been detected to da...
journal_title:FEMS microbiology reviews
pub_type: 杂志文章,评审
doi:10.1111/j.1574-6976.1999.tb00406.x
更新日期:1999-06-01 00:00:00
abstract::Many fungi produce exocellular beta-glucan-degrading enzymes, the beta-glucanases including the noncellulolytic beta-(1,3)- and beta-(1,6)-glucanases, degrading beta-(1,3)- and beta-(1,6)-glucans. An ability to purify several exocellular beta-glucanases attacking the same linkage type from a single fungus is common, a...
journal_title:FEMS microbiology reviews
pub_type: 杂志文章
doi:10.1111/j.1574-6976.2006.00055.x
更新日期:2007-03-01 00:00:00
abstract::The species concept is a recurrent controversial issue that preoccupies philosophers as well as biologists of all disciplines. Prokaryotic species concept has its own history and results from a series of empirical improvements parallel to the development of the techniques of analysis. Among the microbial taxonomists, ...
journal_title:FEMS microbiology reviews
pub_type: 杂志文章,评审
doi:10.1111/j.1574-6976.2001.tb00571.x
更新日期:2001-01-01 00:00:00
abstract::Pathogenicity and symbiosis are central to bacteria-host interactions. Although several human pathogens have been subjected to functional genomic analysis, we still understand little about bacteria-invertebrate interactions despite their ecological prevalence. Advances in our knowledge of this area are often hindered ...
journal_title:FEMS microbiology reviews
pub_type: 杂志文章,评审
doi:10.1111/j.1574-6976.2003.tb00625.x
更新日期:2003-01-01 00:00:00
abstract::Legionella pneumophila is naturally found in fresh water were the bacteria parasitize within protozoa. It also survives planctonically in water or biofilms. Upon aerosol formation via man-made water systems, L. pneumophila can enter the human lung and cause a severe form of pneumonia, called Legionnaires' disease. The...
journal_title:FEMS microbiology reviews
pub_type: 杂志文章,评审
doi:10.1111/j.1574-6976.2002.tb00607.x
更新日期:2002-06-01 00:00:00
abstract::The increasing numbers of characterized base-pairing small RNAs (sRNAs) and the identification of these regulators in a broad range of bacteria are allowing comparisons between species and explorations of sRNA evolution. In this review, we describe some examples of trans-encoded base-pairing sRNAs that are species-spe...
journal_title:FEMS microbiology reviews
pub_type: 杂志文章,评审
doi:10.1093/femsre/fuv014
更新日期:2015-05-01 00:00:00
abstract::The spread of antibiotic resistance and increasing prevalence of biofilm-associated infections is driving demand for new means to treat bacterial infection. Nanotechnology provides an innovative platform for addressing this challenge, with potential to manage even infections involving multidrug-resistant (MDR) bacteri...
journal_title:FEMS microbiology reviews
pub_type: 杂志文章,评审
doi:10.1093/femsre/fux003
更新日期:2017-05-01 00:00:00
abstract::Antibiotics are the most common type of medication prescribed to children, including infants, in the Western world. While use of antibiotics has transformed previously lethal infections into relatively minor diseases, antibiotic treatments can have adverse effects as well. It has been shown in children, adults and ani...
journal_title:FEMS microbiology reviews
pub_type: 杂志文章,评审
doi:10.1093/femsre/fuy018
更新日期:2018-07-01 00:00:00
abstract::The natural light environment is important to many prokaryotes. Most obviously, phototrophic prokaryotes need to acclimate their photosynthetic apparatus to the prevailing light conditions, and such acclimation is frequently complemented by motility to enable cells to relocate in search of more favorable illumination ...
journal_title:FEMS microbiology reviews
pub_type: 杂志文章,评审
doi:10.1093/femsre/fux045
更新日期:2017-11-01 00:00:00
abstract::It has become increasingly and widely recognised that bacteria do not exist as solitary cells, but are colonial organisms that exploit elaborate systems of intercellular communication to facilitate their adaptation to changing environmental conditions. The languages by which bacteria communicate take the form of chemi...
journal_title:FEMS microbiology reviews
pub_type: 杂志文章,评审
doi:10.1111/j.1574-6976.2001.tb00583.x
更新日期:2001-08-01 00:00:00
abstract::Since the 1960s, several new attempts have been made to improve the management of single prokaryotic cells using micromanipulator techniques. In order to facilitate the isolation of pure cultures we have recently developed an improved micromanipulation method for routine work. With the aid of this method single prokar...
journal_title:FEMS microbiology reviews
pub_type: 杂志文章,评审
doi:10.1111/j.1574-6976.2000.tb00558.x
更新日期:2000-12-01 00:00:00
abstract::Conditions that sustain constant bacterial growth are seldom found in nature. Oligotrophic environments and competition among microorganisms force bacteria to be able to adapt quickly to rough and changing situations. A particular lifestyle composed of continuous cycles of growth and starvation is commonly referred to...
journal_title:FEMS microbiology reviews
pub_type: 杂志文章,评审
doi:10.1111/j.1574-6976.2010.00213.x
更新日期:2010-07-01 00:00:00
abstract::The P(II) proteins are one of the most widely distributed families of signal transduction proteins in nature. They are pivotal players in the control of nitrogen metabolism in bacteria and archaea, and are also found in the plastids of plants. Quite remarkably, P(II) proteins control the activities of a diverse rang...
journal_title:FEMS microbiology reviews
pub_type: 杂志文章,评审
doi:10.1111/j.1574-6976.2012.00351.x
更新日期:2013-03-01 00:00:00
abstract::Water is one of the most important bacterial habitats on Earth. As such, water represents also a major way of dissemination of bacteria between different environmental compartments. Human activities led to the creation of the so-called urban water cycle, comprising different sectors (waste, surface, drinking water), a...
journal_title:FEMS microbiology reviews
pub_type: 杂志文章,评审
doi:10.1111/1574-6976.12062
更新日期:2014-07-01 00:00:00
abstract::In recent years, there has been accumulating evidence that antibiotics, besides their antimicrobial action, potentially have a number of undesired side effects that can, at least in some cases, promote genetic variability of bacteria. In addition to resistant variants, antibiotics have also been shown to select mutato...
journal_title:FEMS microbiology reviews
pub_type: 杂志文章,评审
doi:10.1111/j.1574-6976.2009.00165.x
更新日期:2009-05-01 00:00:00
abstract::What a living organism looks like and how it works and what are its components-all this is encoded on DNA, the genetic blueprint. Consequently, the way to change an organism is to change its genetic information. Since the first pieces of recombinant DNA have been used to transform cells in the 1970s, this approach has...
journal_title:FEMS microbiology reviews
pub_type: 杂志文章,评审
doi:10.1093/femsre/fuv030
更新日期:2015-11-01 00:00:00
abstract::Perhaps the biggest single task facing a bacterial cell is to divide into daughter cells that contain the normal complement of chromosomes. Recent technical and conceptual breakthroughs in bacterial cell biology, combined with the flood of genome sequence information and the excellent genetic tools in several model sy...
journal_title:FEMS microbiology reviews
pub_type: 杂志文章,评审
doi:10.1111/j.1574-6976.2000.tb00554.x
更新日期:2000-10-01 00:00:00
abstract::The genus Corynebacterium belongs to the taxonomic class Actinobacteria representing the high G+C branch of gram-positive bacteria. Among the most prominent members of this genus is Corynebacterium glutamicum, which is used by the biotechnological industry for the fermentative production of l-amino acids. Because of i...
journal_title:FEMS microbiology reviews
pub_type: 杂志文章,评审
doi:10.1111/j.1574-6976.2010.00228.x
更新日期:2010-09-01 00:00:00
abstract::Gram-positive bacteria have developed elaborate mechanisms to control ammonium assimilation, at the levels of both transcription and enzyme activity. In this review, the common and specific mechanisms of nitrogen assimilation and regulation in Gram-positive bacteria are summarized and compared for the genera Bacillus,...
journal_title:FEMS microbiology reviews
pub_type: 杂志文章,评审
doi:10.1111/j.1574-6976.2010.00216.x
更新日期:2010-07-01 00:00:00