Heterogeneity of the gut microbiome in mice: guidelines for optimizing experimental design.

Abstract:

:Targeted manipulation of the gut flora is increasingly being recognized as a means to improve human health. Yet, the temporal dynamics and intra- and interindividual heterogeneity of the microbiome represent experimental limitations, especially in human cross-sectional studies. Therefore, rodent models represent an invaluable tool to study the host-microbiota interface. Progress in technical and computational tools to investigate the composition and function of the microbiome has opened a new era of research and we gradually begin to understand the parameters that influence variation of host-associated microbial communities. To isolate true effects from confounding factors, it is essential to include such parameters in model intervention studies. Also, explicit journal instructions to include essential information on animal experiments are mandatory. The purpose of this review is to summarize the factors that influence microbiota composition in mice and to provide guidelines to improve the reproducibility of animal experiments.

journal_name

FEMS Microbiol Rev

authors

Laukens D,Brinkman BM,Raes J,De Vos M,Vandenabeele P

doi

10.1093/femsre/fuv036

subject

Has Abstract

pub_date

2016-01-01 00:00:00

pages

117-32

issue

1

eissn

0168-6445

issn

1574-6976

pii

fuv036

journal_volume

40

pub_type

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