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"Molecular" MR imaging at high fields.

Abstract：

:Magnetic resonance imaging (MRI) and spectroscopy (MRS) have contributed considerably to clinical radiology, and a variety of MR techniques have been developed to evaluate pathological processes as well as normal tissue biology at the cellular and molecular level. However, in comparison to nuclear imaging, MRI has relatively poor sensitivity for detecting true molecular changes or for detecting the presence of targeted contrast agents, though these remain under active development. In recent years very high field (7T and above) MRI systems have been developed for human studies and these provide new opportunities and technical challenges for molecular imaging. We identify 5 types of intrinsic contrast mechanisms that do not require the use of exogenous agents but which can provide molecular and cellular information. We can derive information on tissue composition by (i) imaging different nuclei, especially sodium (ii) exploiting chemical shift differences as in MRS (iii) exploiting specific relaxation mechanisms (iv) exploiting tissue differences in the exchange rates of molecular species such as amides or hydroxyls and (v) differences in susceptibility. The increased signal strength at higher fields enables higher resolution images to be acquired, along with increased sensitivity to detecting subtle effects caused by molecular changes in tissues.

journal_name

Magn Reson Imaging

journal_title

Magnetic resonance imaging

authors

Gore JC,Zu Z,Wang P,Li H,Xu J,Dortch R,Gochberg DF

doi

10.1016/j.mri.2016.12.008

subject

Has Abstract

pub_date

2017-05-01 00:00:00

pages

95-100

eissn

0730-725X

issn

1873-5894

pii

S0730-725X(16)30245-4

journal_volume

38

pub_type

杂志文章

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