Abstract:
AIM:Matrix metalloproteases (MMPs) expression and their inhibitors (TIMPs) play an important role in tumor physiopathology, so we investigated the relationship between the magnetic resonance (MR) and MMPs/TIMPs expression by breast carcinomas. MATERIALS AND METHODS:MRI parameters of 64 breast carcinomas were investigated. An immunohistochemical study was also performed in these cases using tissue microarrays and specific antibodies against MMP-1, MMP-2, MMP-7, MMP-9, MMP-11, MMP-13, MMP-14, TIMP-1, TIMP-2 and TIMP-3. RESULTS:Tumors with spiculated margins had a high global (score) values of MMP-1 or MMP-7, and high expression of TIMP-3 by tumor cells. Heterogeneous tumors had a higher score values of MMP-1, MMP-13, TIMP-2 or TIMP-3, and frequent expression of TIMP-3 by tumor cells. Tumors showing fast enhancement, had higher score values of MMP-1 or MMP-11. Associations between washout curve (type III) and MMP-1, MMP-11, MMP-13 and TIMP-1 expression by tumor cells, were found. CONCLUSIONS:MRI features may predict in some grade the expressions of MMPs/TIMPs in breast tumors, which might to contribute to a better biological characterization of breast cancer.
journal_name
Magn Reson Imagingjournal_title
Magnetic resonance imagingauthors
Cuadriello EF,Fernández-Guinea Ó,Eiró N,González LO,Junquera S,Vizoso FJdoi
10.1016/j.mri.2016.04.005subject
Has Abstractpub_date
2016-10-01 00:00:00pages
1107-13issue
8eissn
0730-725Xissn
1873-5894pii
S0730-725X(16)30017-0journal_volume
34pub_type
杂志文章abstract::Fricke-agarose gels have been irradiated with a proton beam. Then samples have been extracted at different depths with respect to the beam penetration distance, corresponding to different irradiation doses. Relaxation times T1 and T2, measured at 17 MHz, appear sensitive to this kind of radiation. In particular, T2 ex...
journal_title:Magnetic resonance imaging
pub_type: 杂志文章
doi:10.1016/s0730-725x(96)00380-3
更新日期:1997-01-01 00:00:00
abstract::Focal brain ischemia was induced by middle cerebral artery occlusion in the rat. The volume of cerebral damage was determined 2 days later by MRI in vivo and in the same animals histologically. The edema volume as measured by MRI and the histologically determined infarction was highly correlated. As a consequence, the...
journal_title:Magnetic resonance imaging
pub_type: 杂志文章
doi:10.1016/0730-725x(92)90411-r
更新日期:1992-01-01 00:00:00
abstract::A case report of trismus after a dental procedure is evaluated by MR imaging. The medial and lateral pterygoid muscles showed inflammatory changes. Etiologies of trismus are reviewed. ...
journal_title:Magnetic resonance imaging
pub_type: 杂志文章
doi:10.1016/0730-725x(90)90148-u
更新日期:1990-01-01 00:00:00
abstract::The aim of this study was to evaluate intracranial arterial stenoses and aneurysms with accelerated time-resolved three-dimensional (3D) phase-contrast MRI or 4D flow. The 4D flow technique was utilized to image four normal volunteers, two patients with intracranial stenoses and two patients with intracranial aneurysm...
journal_title:Magnetic resonance imaging
pub_type: 杂志文章
doi:10.1016/j.mri.2009.05.042
更新日期:2010-01-01 00:00:00
abstract::When assessing liver iron content using relaxometry, an average relaxation rate (R1, R2 or R2*) is usually determined from a region of interest or the entire liver. This is commonly performed by fitting the signal decay in individual voxels to an appropriate relaxation function. The voxel-level parameters resulting fr...
journal_title:Magnetic resonance imaging
pub_type: 杂志文章
doi:10.1016/j.mri.2010.11.005
更新日期:2011-05-01 00:00:00
abstract::The purpose of this study was to develop a method to determine time discrepancies between input and myocardial time-signal intensity (TSI) curves for accurate estimation of myocardial perfusion with first-pass contrast-enhanced MRI. Estimation of myocardial perfusion with contrast-enhanced MRI using kinetic models req...
journal_title:Magnetic resonance imaging
pub_type: 杂志文章
doi:10.1016/j.mri.2015.06.015
更新日期:2015-11-01 00:00:00
abstract::The clinical evaluation of three-dimensional time-of-flight MR angiography was prospectively performed in 16 patients with intracranial meningioma. MR angiographic techniques used in this study both with and without gadopentetate dimeglumine made it possible to demonstrate the topographic relationship between the tumo...
journal_title:Magnetic resonance imaging
pub_type: 杂志文章
doi:10.1016/0730-725x(93)90466-q
更新日期:1993-01-01 00:00:00
abstract::In this study, magnetic resonance imaging (MRI) was used to dynamically visualize the diffusion process of CO2 in porous media saturated with liquid hydrocarbon. Based on the assumption of semi-infinite media, effective CO2 diffusivity was obtained directly by the nonlinear fitting of one MR profile during the diffusi...
journal_title:Magnetic resonance imaging
pub_type: 杂志文章
doi:10.1016/j.mri.2015.12.024
更新日期:2016-05-01 00:00:00
abstract::Automatic segmentation of different types of tissue from magnetic resonance images is of great importance for clinical and research applications, particularly large-scale and longitudinal studies of brain pathology. We developed a fully automated algorithm for the segmentation of lateral ventricles from cranial magnet...
journal_title:Magnetic resonance imaging
pub_type: 杂志文章
doi:10.1016/j.mri.2006.08.013
更新日期:2006-12-01 00:00:00
abstract::For a number of reasons, it is desirable to fabricate coils which, for a known current, shall produce predetermined values of the magnetic field intensity at a number of points within a nuclear magnetic resonance imager. The calculation of the magnetic field intensity at a set of points involves the integration of the...
journal_title:Magnetic resonance imaging
pub_type: 杂志文章
doi:10.1016/0730-725x(89)90524-9
更新日期:1989-11-01 00:00:00
abstract::Left ventricle (LV) segmentation plays an important role in the diagnosis of cardiovascular diseases. The cardiac contractile function can be quantified by measuring the segmentation results of LVs. Fully convolutional networks (FCNs) have been proven to be able to segment images. However, a large number of annotated ...
journal_title:Magnetic resonance imaging
pub_type: 杂志文章
doi:10.1016/j.mri.2019.08.004
更新日期:2020-02-01 00:00:00
abstract::Serious adverse reactions following the IV administration of Gd-DTPA (Magnevist, gadopenetate dimeglumine, Berlex Laboratories, Wayne, NJ), although extremely rare, can occur. As yet, there has been no published case of a severe anaphylactoid-type reaction to Gd-DTPA. ...
journal_title:Magnetic resonance imaging
pub_type: 杂志文章
doi:10.1016/0730-725x(90)90019-x
更新日期:1990-01-01 00:00:00
abstract:PURPOSE:A direct correlation between T(1ρ), T(2) and quantified proteoglycan and collagen contents in human osteoarthritic cartilage has yet to be documented. We aimed to investigate the orientation effect on T(1ρ) and T(2) values in human osteoarthritic cartilage and to quantify the correlation between T(1ρ), T(2) vs....
journal_title:Magnetic resonance imaging
pub_type: 杂志文章
doi:10.1016/j.mri.2010.09.004
更新日期:2011-04-01 00:00:00
abstract::Current fast imaging techniques are based on gradient echo sequences with reduced flip angle excitation pulses and very short repetition times TR. Practical T2 values may be of the order of TR or longer. In this situation, a different image contrast can be obtained, depending on details of the sequence. Four essential...
journal_title:Magnetic resonance imaging
pub_type: 杂志文章,评审
doi:10.1016/0730-725x(88)90472-9
更新日期:1988-07-01 00:00:00
abstract::The most recently reported magnetic resonance first-pass myocardial perfusion studies were restricted to single slice imaging or a data analysis based on interactively placed regions of interest. This study was designed to investigate a new saturation recovery TurboFLASH sequence for multisection myocardial perfusion ...
journal_title:Magnetic resonance imaging
pub_type: 杂志文章
doi:10.1016/s0730-725x(98)00166-0
更新日期:1999-02-01 00:00:00
abstract::We present the case of a 44-year-old man who complained of cervical pain. He was treated with physiotherapy and analgetics. Because of persistent pain, computed tomography (CT) scan and MRI were performed. They revealed an osteolytic destruction of the fourth cervical vertebra. The patient was treated surgically for r...
journal_title:Magnetic resonance imaging
pub_type: 杂志文章,评审
doi:10.1016/j.mri.2004.01.006
更新日期:2004-05-01 00:00:00
abstract:INTRODUCTION:Previous investigations of test-retest reliability of cerebral blood flow (CBF) at rest measured with pseudo-continuous Arterial Spin Labeling (pCASL) demonstrated good reliability, but are limited by the use of similar scanner platforms. In the present study we examined test-retest reliability of CBF in r...
journal_title:Magnetic resonance imaging
pub_type: 杂志文章
doi:10.1016/j.mri.2017.09.004
更新日期:2018-01-01 00:00:00
abstract::The objective of our study was to assess the feasibility of dynamic susceptibility contrast MR technique after bolus injection of SPIO and Gd-DOTA in a tumor model implanted in rats. Tumors were subcutaneously implanted in 24 rats. A FLASH sequence and EPI were evaluated. Different doses of AMI 227 and Gd-DOTA were as...
journal_title:Magnetic resonance imaging
pub_type: 杂志文章
doi:10.1016/s0730-725x(98)00197-0
更新日期:1999-05-01 00:00:00
abstract::The subthalamic nucleus (STN) is one of the most common stimulation targets for treating Parkinson's disease using deep brain stimulation (DBS). This procedure requires precise placement of the stimulating electrode. Common practice of DBS implantation utilizes microelectrode recording to locate the sites with the cor...
journal_title:Magnetic resonance imaging
pub_type: 杂志文章
doi:10.1016/j.mri.2012.02.006
更新日期:2012-06-01 00:00:00
abstract::In magnetic resonance elastography (MRE), shear waves at a certain frequency are encoded through bipolar gradients that switch polarity at a controlled encoding frequency and are offset in time to capture wave propagation using a controlled sampling frequency. In brain MRE, there is a possibility that the mechanical a...
journal_title:Magnetic resonance imaging
pub_type: 杂志文章
doi:10.1016/j.mri.2011.09.017
更新日期:2012-02-01 00:00:00
abstract::Until recently, NMR imaging with intermolecular multiple-quantum coherences (iMQCs) has been based on the acquisition of a single echo. In vivo studies of iMQC image contrast would greatly benefit from a method that could acquire several orders of quantum coherence during the same acquisition. This would enable compar...
journal_title:Magnetic resonance imaging
pub_type: 杂志文章
doi:10.1016/j.mri.2004.10.019
更新日期:2004-12-01 00:00:00
abstract::To assess whether magnetic resonance imaging could assist in diagnosing Ewing sarcoma, we retrospectively analyzed T1- and T2-weighted images of 24 consecutive solitary lytic bone lesions, including 18 cases of histologically proven Ewing sarcoma, and six aggressive-appearing benign lesions including eosinophilic gran...
journal_title:Magnetic resonance imaging
pub_type: 杂志文章
doi:10.1016/0730-725x(94)92450-3
更新日期:1994-01-01 00:00:00
abstract::In this paper the effects of reducing the flip angle of the 90-degree observation pulse in inversion recovery imaging are described and analyzed. When incorporated in an IR sequence with a short inversion time (STIR), reduction to the 90-degree pulse allows a significant shortening of the repetition time without loss ...
journal_title:Magnetic resonance imaging
pub_type: 杂志文章
doi:10.1016/0730-725x(91)90418-l
更新日期:1991-01-01 00:00:00
abstract::A quantitative analysis of the dependence of water proton relaxation on water content in randomly packed beds of Sephadex is undertaken. A combination of Osmotic and Capillary theory is used to describe the morphological changes occurring in the packed beds as the water content is lowered. At each water content the wa...
journal_title:Magnetic resonance imaging
pub_type: 杂志文章
doi:10.1016/0730-725x(94)92032-x
更新日期:1994-01-01 00:00:00
abstract::Biliary cystadenomas and their malignant counterparts, biliary cystadenocarcinomas, are rare cystic tumors that arise from hepatobiliary epithelium. Ultrasound (US) and computed tomography (CT) are the initial imaging modalities used for the evaluation of biliary cystic tumors, but are not specific. MRI and MRCP, beca...
journal_title:Magnetic resonance imaging
pub_type: 杂志文章
doi:10.1016/s0730-725x(01)00453-2
更新日期:2001-11-01 00:00:00
abstract::Magnetic resonance imaging (MRI) has played an important role in the diagnosis and management of cancer since it was first developed, but other modalities also continue to advance and provide complementary information on the status of tumors. In the future, there will be a major continuing role for noninvasive imaging...
journal_title:Magnetic resonance imaging
pub_type: 杂志文章,评审
doi:10.1016/j.mri.2011.02.003
更新日期:2011-06-01 00:00:00
abstract::We present a novel approach to the nuclear magnetic resonance (NMR) and magnetic resonance imaging (MRI) analysis of complex samples with nontrivial distribution of longitudinal relaxation rate R(1). Parametrically enabled relaxation filters with double and multiple inversion (PERFIDI) aim to separate signals arising ...
journal_title:Magnetic resonance imaging
pub_type: 杂志文章
doi:10.1016/j.mri.2006.12.001
更新日期:2007-05-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Slice-encoding metal artifact corrections (SEMAC)-view-angle tilting (VAT) sequences have recently been used in clinical protocols to reduce metal artifacts in MR scans of patients with spinal instrumentation. The objective of this study was to compare the SEMAC-VAT sequence with the conventional...
journal_title:Magnetic resonance imaging
pub_type: 杂志文章
doi:10.1016/j.mri.2018.08.002
更新日期:2018-12-01 00:00:00
abstract::A new and simple method for precise determination of lateral opposed treatment portals was developed and used in 17 patients. Compared to CT, MRI led to significant changes of portals in 59% (10/17) of cases. Individual shielding blocks could be precisely designed by use of our new method. MRI is the procedure of choi...
journal_title:Magnetic resonance imaging
pub_type: 杂志文章
doi:10.1016/0730-725x(91)90007-9
更新日期:1991-01-01 00:00:00
abstract::Tracking of signal intensity changes in soft tissue over time is often hampered by deformation of the tissue. In this study a method is described that uses finite element modeling to compensate for tissue deformation. The method is applied to the quantification of fluid redistribution in an intervertebral disc that de...
journal_title:Magnetic resonance imaging
pub_type: 杂志文章
doi:10.1016/s0730-725x(97)00251-8
更新日期:1998-01-01 00:00:00