Quantitative MRI using T1ρ and T2 in human osteoarthritic cartilage specimens: correlation with biochemical measurements and histology.


PURPOSE:A direct correlation between T(1ρ), T(2) and quantified proteoglycan and collagen contents in human osteoarthritic cartilage has yet to be documented. We aimed to investigate the orientation effect on T(1ρ) and T(2) values in human osteoarthritic cartilage and to quantify the correlation between T(1ρ), T(2) vs. biochemical composition and histology in human osteoarthritic cartilage. MATERIALS AND METHODS:Thirty-three cartilage specimens were collected from patients who underwent total knee arthroplasty due to severe osteoarthritis and scanned with a 3T MR scanner for T(1ρ) and T(2) quantification. Nine specimens were scanned at three different orientations with respect to the B(0): 0°, 90° and 54.7°. Core punches were taken after MRI. Collagen and proteoglycan contents were quantified using biochemical assays. Histology sections were graded using Mankin scores. The correlation between imaging parameters, biochemical contents and histological scores were studied. RESULTS:Both mean T(1ρ) and T(2) at 54.7° were significantly higher than those measured at 90° and 0°, with T(1ρ) showing less increase compared to T(2). R(1ρ) (1/T(1ρ)) values had a significant but moderate correlation with proteoglycan contents (R=.45, P=.002), while R(2) (1/T(2)) was not correlated with proteoglycan. No significant correlation was found between relaxation times (T(1ρ) or T(2)) and collagen contents. The T(1ρ) values of specimen sections with high Mankin scores were significantly higher than those with low Mankin scores (P<.05). CONCLUSIONS:Quantitative MRI has a great potential to provide noninvasive imaging biomarkers for cartilage degeneration in osteoarthritis.


Magn Reson Imaging


Li X,Cheng J,Lin K,Saadat E,Bolbos RI,Jobke B,Ries MD,Horvai A,Link TM,Majumdar S




Has Abstract


2011-04-01 00:00:00














  • Balanced steady state free precession for arterial spin labeling MRI: Initial experience for blood flow mapping in human brain, retina, and kidney.

    abstract::We implemented pseudo-continuous ASL (pCASL) with 2D and 3D balanced steady state free precession (bSSFP) readout for mapping blood flow in the human brain, retina, and kidney, free of distortion and signal dropout, which are typically observed in the most commonly used echo-planar imaging acquisition. High resolution...

    journal_title:Magnetic resonance imaging

    pub_type: 杂志文章


    authors: Park SH,Wang DJ,Duong TQ

    更新日期:2013-09-01 00:00:00

  • 7T GRE-MRI signal compartments are sensitive to dysplastic tissue in focal epilepsy.

    abstract::Ultra-high field magnetic resonance imaging data obtained using a multi-echo gradient echo sequence has been shown to contain information on tissue microstructure. Quantitative assessment of water fraction, relaxation time and frequency shift using multi-compartment signal modelling may help improve our understanding ...

    journal_title:Magnetic resonance imaging

    pub_type: 杂志文章


    authors: Thapaliya K,Urriola J,Barth M,Reutens DC,Bollmann S,Vegh V

    更新日期:2019-09-01 00:00:00

  • 1H magnetic resonance imaging and 31P magnetic resonance spectroscopy in experimental filariasis.

    abstract::1H Magnetic resonance imaging and 31P magnetic resonance spectroscopy (MRS) have been carried out in experimental rodent filariasis, i.e., Acanthocheilonema viteae infection in the rodent host, Mastomys coucha. The T2-weighted image of the infected host shows fine hyperintense thread like structures of adult filariid ...

    journal_title:Magnetic resonance imaging

    pub_type: 杂志文章


    authors: Shukla-Dave A,Fatma N,Roy R,Srivastava S,Chatterjee RK,Govindaraju V,Viswanathan AK,Raghunathan P

    更新日期:1997-01-01 00:00:00

  • Voxel-Wise Logistic Regression and Leave-One-Source-Out Cross Validation for white matter hyperintensity segmentation.

    abstract::Many algorithms have been proposed for automated segmentation of white matter hyperintensities (WMH) in brain MRI. Yet, broad uptake of any particular algorithm has not been observed. In this work, we argue that this may be due to variable and suboptimal validation data and frameworks, precluding direct comparison of ...

    journal_title:Magnetic resonance imaging

    pub_type: 杂志文章


    authors: Knight J,Taylor GW,Khademi A

    更新日期:2018-12-01 00:00:00

  • In vivo nuclear magnetic resonance imaging and spectroscopy of aquatic organisms.

    abstract::NMR imaging and localized 1H spectroscopy of a variety of aquatic organisms in vivo is described for the first time. The practical consideration of life support, water volume, salinity, and anesthesia are discussed and solutions presented. Such animal studies shape our understanding of physiology, biochemistry, and bi...

    journal_title:Magnetic resonance imaging

    pub_type: 杂志文章


    authors: Blackband SJ,Stoskopf MK

    更新日期:1990-01-01 00:00:00

  • MR angiography of meningioma.

    abstract::The clinical evaluation of three-dimensional time-of-flight MR angiography was prospectively performed in 16 patients with intracranial meningioma. MR angiographic techniques used in this study both with and without gadopentetate dimeglumine made it possible to demonstrate the topographic relationship between the tumo...

    journal_title:Magnetic resonance imaging

    pub_type: 杂志文章


    authors: Kadota T,Kuriyama K,Inoue E,Fujita M,Nakagawa H,Kuroda C

    更新日期:1993-01-01 00:00:00

  • Influence of cholecystectomy on the flow dynamic pattern of bile in the extrahepatic bile duct: Assessment by cine-dynamic MRCP with spatially-selective IR pulse.

    abstract:PURPOSE:To evaluate the influence of cholecystectomy on the flow dynamic pattern of bile in the extrahepatic bile duct by using cine-dynamic MRCP with spatially-selective inversion-recovery (IR) pulse non-invasively. MATERIALS AND METHODS:56 patients with cholecystectomy and 48 control subjects without cholecystectomy...

    journal_title:Magnetic resonance imaging

    pub_type: 杂志文章


    authors: Sotozono H,Tamada T,Kanki A,Yasokawa K,Fukunaga T,Yamamoto A,Ito K

    更新日期:2020-12-01 00:00:00

  • Alterations in diffusion properties of white matter in Williams syndrome.

    abstract::Diffusion tensor imaging (DTI) was used to investigate the involvement of brain white matter in Williams syndrome (WS), a genetic neurodevelopmental disorder. Whole-brain DTIs were obtained from 16 young adults with WS and 16 normal controls. A voxel-based analysis was performed to compare fractional anisotropy (FA) v...

    journal_title:Magnetic resonance imaging

    pub_type: 杂志文章


    authors: Arlinghaus LR,Thornton-Wells TA,Dykens EM,Anderson AW

    更新日期:2011-11-01 00:00:00

  • Quantitative 1H MRS in the evaluation of mesial temporal lobe epilepsy in vivo.

    abstract::Hippocampal metabolite concentrations were determined by localized in vivo proton magnetic resonance spectroscopy (1H MRS) in eleven patients suffering from refractory mesial temporal lobe epilepsy (MTLE), as well as in eleven age-matched healthy volunteers, and compared with patient history, postoperative outcome and...

    journal_title:Magnetic resonance imaging

    pub_type: 杂志文章


    authors: Duc CO,Trabesinger AH,Weber OM,Meier D,Walder M,Wieser HG,Boesiger P

    更新日期:1998-10-01 00:00:00

  • Removal of extracerebral tissues in dual-echo magnetic resonance images via linear scale-space features.

    abstract::The location and masking of the brain and surrounding cerebrospinal fluid (CSF) in two-dimensional (2D) dual-echo fast spin-echo (FSE) magnetic resonance (MR) images of the head is achieved by an automated procedure with a voxel-based computational algorithm. Linear scale-space features are derived from the short-echo...

    journal_title:Magnetic resonance imaging

    pub_type: 杂志文章


    authors: Suckling J,Brammer MJ,Lingford-Hughes A,Bullmore ET

    更新日期:1999-02-01 00:00:00

  • Effects of gadoxetic acid on liver elasticity measurement by using magnetic resonance elastography.

    abstract::The purpose of this study was to evaluate the effect of gadoxetic acid (Gd-EOB-DTPA) on measurements of liver stiffness by using magnetic resonance elastography (MRE). In this study, 104 consecutive patients (mean age, 67.7±9.4 years) underwent MRE using a 1.5-T MR scanner equipped with a cylindrical passive driver th...

    journal_title:Magnetic resonance imaging

    pub_type: 杂志文章


    authors: Motosugi U,Ichikawa T,Sou H,Sano K,Muhi A,Ehman RL,Araki T

    更新日期:2012-01-01 00:00:00

  • Controlled delivery of Gd-containing liposomes to lymph nodes: surface modification may enhance MRI contrast properties.

    abstract::Surface modification of liposomes containing Gd-diethylenetriaminepentaacetyl-phosphatidylethanolamine (Gd-DTPA-PE) as an amphiphilic paramagnetic label influences their contrast properties as MRI agents. Liposomes with the mean diameter ca. 220 nm and 10% mol content of Gd-DTPA-PE were modified with dextran (molecula...

    journal_title:Magnetic resonance imaging

    pub_type: 杂志文章


    authors: Trubetskoy VS,Cannillo JA,Milshtein A,Wolf GL,Torchilin VP

    更新日期:1995-01-01 00:00:00

  • Reducing SAR in parallel excitation using variable-density spirals: a simulation-based study.

    abstract::Parallel excitation using multiple transmit channels has emerged as an effective method to shorten multidimensional spatially selective radiofrequency (RF) pulses, which have a number of important applications, including B1 field inhomogeneity correction in high-field MRI. The specific absorption rate (SAR) is a prima...

    journal_title:Magnetic resonance imaging

    pub_type: 杂志文章


    authors: Liu Y,Feng K,McDougall MP,Wright SM,Ji J

    更新日期:2008-10-01 00:00:00

  • Temporal sampling requirements for the tracer kinetics modeling of breast disease.

    abstract::The physiological parameters measured in the tracer kinetics modeling of data from a dynamic contrast-enhanced magnetic resonance (MR) breast exam (blood flow-extraction fraction product [FE], volume of the extracellular extravascular space [Ve], and blood volume [Vb]) may enable non-invasive diagnosis of breast cance...

    journal_title:Magnetic resonance imaging

    pub_type: 杂志文章


    authors: Henderson E,Rutt BK,Lee TY

    更新日期:1998-11-01 00:00:00

  • Accurate and sensitive measurements of magnetic susceptibility using echo planar imaging.

    abstract::Susceptibility differences are common causes for artifacts in magnetic resonance (MR); therefore, it is important to choose phantom materials in a way that these artifacts are kept at a minimum. In this study, a previously proposed MR imaging (MRI) method [Beuf O, Briguet A, Lissac M, Davis R. Magnetic resonance imagi...

    journal_title:Magnetic resonance imaging

    pub_type: 杂志文章


    authors: Carlsson A,Starck G,Ljungberg M,Ekholm S,Forssell-Aronsson E

    更新日期:2006-11-01 00:00:00

  • Off-resonance frequency filtered magnetic resonance imaging.

    abstract::One of the main problems with rapid magnetic resonance imaging (MRI) techniques is the artifacts that result from off-resonance effects. The proposed off-resonance frequency filtered MRI (OFF-MRI) method focuses on the elimination of off-resonance components from the image of the observed object. To maintain imaging s...

    journal_title:Magnetic resonance imaging

    pub_type: 杂志文章


    authors: Medic J,Tomazic S

    更新日期:2010-05-01 00:00:00

  • Quantitative magnetic resonance imaging of 'Fuyu' persimmon fruit during development and ripening.

    abstract::Qualitative and quantitative proton magnetic resonance imaging techniques were applied to persimmon (Diospyros kaki cv 'Fuyu') fruit during development and post-harvest ripening. Spin-lattice (T(1)) relaxation times in mesocarp parenchyma and vascular tissue exhibited a sigmoidal pattern of increase leading to commerc...

    journal_title:Magnetic resonance imaging

    pub_type: 杂志文章


    authors: Clark CJ,MacFall JS

    更新日期:2003-07-01 00:00:00

  • Determination of blood circulation times of superparamagnetic iron oxide nanoparticles by T2* relaxometry using ultrashort echo time (UTE) MRI.

    abstract::Blood circulation is an important determinant of the biodistribution of superparamagnetic iron oxide nanoparticles. Here we present a magnetic resonance imaging (MRI) technique based on the use of ultrafast echo times (UTE) for the noninvasive determination of blood half-lives at high particle concentrations, when con...

    journal_title:Magnetic resonance imaging

    pub_type: 杂志文章


    authors: Scharlach C,Warmuth C,Schellenberger E

    更新日期:2015-11-01 00:00:00

  • A simulation-based comparison of two methods for determining relaxation rates from relaxometry images.

    abstract::When assessing liver iron content using relaxometry, an average relaxation rate (R1, R2 or R2*) is usually determined from a region of interest or the entire liver. This is commonly performed by fitting the signal decay in individual voxels to an appropriate relaxation function. The voxel-level parameters resulting fr...

    journal_title:Magnetic resonance imaging

    pub_type: 杂志文章


    authors: Marro K,Otto R,Kolokythas O,Shimamura A,Sanders JE,McDonald GB,Friedman SD

    更新日期:2011-05-01 00:00:00

  • Nuclear magnetic resonance imaging techniques as developed modestly within a university medical center environment: what can the small system contribute at this point?

    abstract::This paper describes a geometrically small NMR imaging system which has been developed and assembled within a university medical center environment. Consideration is given to the technical specifications and basic economics for the magnet system, NMR spectrometer, and computer configuration. Initial research objective...

    journal_title:Magnetic resonance imaging

    pub_type: 杂志文章


    authors: Thomas SR,Ackerman JL,Goebel JR,Davis M,Kereiakes JG,Lin YY

    更新日期:1982-01-01 00:00:00

  • Is 'virtual histology' the next step after the 'virtual autopsy'? Magnetic resonance microscopy in forensic medicine.

    abstract:AIM:The study aimed to validate magnetic resonance microscopy (MRM) studies of forensic tissue specimens (skin samples with electric injury patterns) against the results from routine histology. METHODS AND RESULTS:Computed tomography and magnetic resonance imaging are fast becoming important tools in clinical and fore...

    journal_title:Magnetic resonance imaging

    pub_type: 杂志文章


    authors: Thali MJ,Dirnhofer R,Becker R,Oliver W,Potter K

    更新日期:2004-10-01 00:00:00

  • Quantifying the dynamic density driven convection in high permeability packed beds.

    abstract::The density driven convection phenomenon is expected to have a significant and positive role in CO2 geological storage capacity and safety. The onset and development of density-driven convective on the core scale is critical to understand the mass transfer mechanism. In this paper, laboratory experiments were conducte...

    journal_title:Magnetic resonance imaging

    pub_type: 杂志文章


    authors: Teng Y,Jiang L,Fan Y,Liu Y,Wang D,Abudula A,Song Y

    更新日期:2017-06-01 00:00:00

  • Synthesis of magnetic gradients for NMR tomography.

    abstract::A numerical method is applied to calculate an optimal distribution of currents in air which generate the magnetic field gradients required to spatially encode the radiofrequency signal in a NMR tomographic experiment. We compare the performances of the gradient circuits for the whole body air-core electromagnet descri...

    journal_title:Magnetic resonance imaging

    pub_type: 杂志文章


    authors: Mustarelli P,Rudnicki M,Savini A,Savoldi F,Villa M

    更新日期:1990-01-01 00:00:00

  • Flexible, phase-matched, linear receive arrays for high-field MRI in monkeys.

    abstract::High signal-to-noise ratios (SNR) are essential for high-resolution anatomical and functional MRI. Phased arrays are advantageous for this but have the drawback that they often have inflexible and bulky configurations. Particularly in experiments where functional MRI is combined with simultaneous electrophysiology, sp...

    journal_title:Magnetic resonance imaging

    pub_type: 杂志文章


    authors: Goense J,Logothetis NK,Merkle H

    更新日期:2010-10-01 00:00:00

  • The use of Gd-DOTA in magnetic resonance imaging of experimentally induced mammary tumors.

    abstract::Gd-DOTA contrast enhancement of MR images was evaluated on induced mammary tumors in female rats. A single intravenous injection of the carcinogenic N-nitrosourea ENU was administered to Wistar rats; this simple treatment led to a high percentage of mammary tumors without causing death. All the induced tumors were ade...

    journal_title:Magnetic resonance imaging

    pub_type: 杂志文章


    authors: Bonnet PA,Michel A,Fernandez JP,Cyteval C,Rifai A,Boucard M,Chapat JP,Lamarque JL

    更新日期:1990-01-01 00:00:00

  • Differentiation of hepatomas from nonhepatomatous masses: use of MnDPDP-enhanced MR images.

    abstract::Manganese (II) N,N'-dipyridoxylethylenediamine-N,N' diacetate 5,5'-bis(phosphate) (MnDPDP) is a hepatobiliary agent that is incorporated into the hepatocyte. We retrospectively reviewed our experience with 39 focal liver lesions in 20 patients studies with MnDPDP-enhanced hepatic magnetic resonance (MR) imaging to det...

    journal_title:Magnetic resonance imaging

    pub_type: 杂志文章


    authors: Liou J,Lee JK,Borrello JA,Brown JJ

    更新日期:1994-01-01 00:00:00

  • Signal and contrast effects due to T2 decay during k-space readout of UTE (ultrashort TE) sequences.

    abstract::In ultrashort TE (UTE) imaging, the short T2 values of the tissues of interest are comparable to the k-space readout duration, which result in significant T2 decay during k-space readout. This decay consequently causes significant effects on signal and contrast in UTE sequences, which we evaluate in this paper using m...

    journal_title:Magnetic resonance imaging

    pub_type: 杂志文章


    authors: Chiang JT,Carl M,Du J

    更新日期:2014-04-01 00:00:00

  • Initial changes of non-traumatic osteonecrosis of femoral head in fat suppression images: bone marrow edema was not found before the appearance of band patterns.

    abstract::The present study examined initial changes in non-traumatic osteonecrosis of the femoral head (ONF) on T1- and T2-weighted MR images, and fat suppression images. The subjects were 57 renal transplant recipients (37 males and 20 females), whose median age at the time of transplantation was 31.5 years old (range, 10 to ...

    journal_title:Magnetic resonance imaging

    pub_type: 杂志文章


    authors: Fujioka M,Kubo T,Nakamura F,Shibatani M,Ueshima K,Hamaguchi H,Inoue S,Sugano N,Sakai T,Torii Y,Hasegawa Y,Hirasawa Y

    更新日期:2001-09-01 00:00:00

  • Three-dimensional adiabatic inversion recovery prepared ultrashort echo time cones (3D IR-UTE-Cones) imaging of cortical bone in the hip.

    abstract:PURPOSE:We present three-dimensional adiabatic inversion recovery prepared ultrashort echo time Cones (3D IR-UTE-Cones) imaging of cortical bone in the hip of healthy volunteers using a clinical 3T scanner. METHODS:A 3D IR-UTE-Cones sequence, based on a short pulse excitation followed by a 3D Cones trajectory, with a ...

    journal_title:Magnetic resonance imaging

    pub_type: 杂志文章


    authors: Nazaran A,Carl M,Ma Y,Jerban S,Zhu Y,Lu X,Du J,Chang EY

    更新日期:2017-12-01 00:00:00

  • Hepatic sarcoidosis: MR appearances in patients with chronic liver disease.

    abstract:PURPOSE:To describe the MR appearances of hepatic sarcoidosis in patients with chronic liver disease and correlate the results with clinical stage of disease as measured with the Mayo end-stage liver disease (MELD) score. MATERIALS AND METHODS:Twenty patients with chronic liver disease and histopathological diagnosis ...

    journal_title:Magnetic resonance imaging

    pub_type: 杂志文章


    authors: Ferreira A,Ramalho M,de Campos RO,Heredia V,Roque A,Vaidean G,Semelka RC

    更新日期:2013-04-01 00:00:00