Abstract:
PURPOSE:A direct correlation between T(1ρ), T(2) and quantified proteoglycan and collagen contents in human osteoarthritic cartilage has yet to be documented. We aimed to investigate the orientation effect on T(1ρ) and T(2) values in human osteoarthritic cartilage and to quantify the correlation between T(1ρ), T(2) vs. biochemical composition and histology in human osteoarthritic cartilage. MATERIALS AND METHODS:Thirty-three cartilage specimens were collected from patients who underwent total knee arthroplasty due to severe osteoarthritis and scanned with a 3T MR scanner for T(1ρ) and T(2) quantification. Nine specimens were scanned at three different orientations with respect to the B(0): 0°, 90° and 54.7°. Core punches were taken after MRI. Collagen and proteoglycan contents were quantified using biochemical assays. Histology sections were graded using Mankin scores. The correlation between imaging parameters, biochemical contents and histological scores were studied. RESULTS:Both mean T(1ρ) and T(2) at 54.7° were significantly higher than those measured at 90° and 0°, with T(1ρ) showing less increase compared to T(2). R(1ρ) (1/T(1ρ)) values had a significant but moderate correlation with proteoglycan contents (R=.45, P=.002), while R(2) (1/T(2)) was not correlated with proteoglycan. No significant correlation was found between relaxation times (T(1ρ) or T(2)) and collagen contents. The T(1ρ) values of specimen sections with high Mankin scores were significantly higher than those with low Mankin scores (P<.05). CONCLUSIONS:Quantitative MRI has a great potential to provide noninvasive imaging biomarkers for cartilage degeneration in osteoarthritis.
journal_name
Magn Reson Imagingjournal_title
Magnetic resonance imagingauthors
Li X,Cheng J,Lin K,Saadat E,Bolbos RI,Jobke B,Ries MD,Horvai A,Link TM,Majumdar Sdoi
10.1016/j.mri.2010.09.004subject
Has Abstractpub_date
2011-04-01 00:00:00pages
324-34issue
3eissn
0730-725Xissn
1873-5894pii
S0730-725X(10)00308-5journal_volume
29pub_type
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journal_title:Magnetic resonance imaging
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更新日期:1985-01-01 00:00:00
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pub_type: 临床试验,杂志文章
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journal_title:Magnetic resonance imaging
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更新日期:2016-05-01 00:00:00
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journal_title:Magnetic resonance imaging
pub_type: 杂志文章
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更新日期:2010-11-01 00:00:00
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journal_title:Magnetic resonance imaging
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更新日期:2008-11-01 00:00:00
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journal_title:Magnetic resonance imaging
pub_type: 杂志文章
doi:10.1016/j.mri.2003.07.001
更新日期:2004-01-01 00:00:00
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pub_type: 杂志文章
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更新日期:2004-10-01 00:00:00