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Cortical morphologic changes in recent-onset, drug-naïve idiopathic generalized epilepsy.

Abstract：

PURPOSE:Only a few studies have investigated the brain morphology abnormalities in structural MRI in patients with drug-naïve idiopathic generalized epilepsy (IGE) and mainly focused on brain volume changes. In the present study, we aimed to investigate the changes in three morphologic measurement differences including cortical thickness, cortical volume, and surface area using FreeSurfer in a pediatric cohort of recent-onset, drug-naïve IGE. METHODS:Forty-five recent-onset, drug-naïve patients diagnosed with IGE and 32 demographically matched healthy controls were recruited. All participants underwent structural MRI scans with a 3.0 T MR system. FreeSurfer, an automated cortical surface reconstruction toolbox, was applied to compare the cortical morphology between patients and controls. The brain regions with significant group differences after multiple comparison correction were extracted in common space for each patient, and then correlated with their clinical characteristics (including onset age, duration of epilepsy, and mini-mental state examination (MMSE)) using partial correlation analysis with age, sex and intracranial volume as covariates. RESULTS:Compared with controls, IGE patients showed decreased cortical thickness in the left rostral middle frontal gyrus, decreased cortical volume in the right cuneus and left superior frontal gyrus that extended to the precentral gyrus, and decreased surface area in the right cuneus and right inferior parietal gyrus. None of these regions showed significant relationships with clinical measurements in the patient group. CONCLUSION:Our findings suggest that cortical thickness, cortical volume, and surface area changes occurred in the early stage of IGE. These findings provide structural neuroimaging evidence underlying the pathology of IGE.

journal_name

Magn Reson Imaging

journal_title

Magnetic resonance imaging

authors

Deng DM,Chen LZ,Li YW,Long R,Tang GC,Han FG,Diao XM,Chen HL,Long ZL,Qiu LH

doi

10.1016/j.mri.2019.05.035

subject

Has Abstract

pub_date

2019-09-01 00:00:00

pages

137-142

eissn

0730-725X

issn

1873-5894

pii

S0730-725X(18)30679-9

journal_volume

61

pub_type

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