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Simultaneous acquisition of multiple orders of intermolecular multiple-quantum coherence images in vivo.

Abstract：

:Until recently, NMR imaging with intermolecular multiple-quantum coherences (iMQCs) has been based on the acquisition of a single echo. In vivo studies of iMQC image contrast would greatly benefit from a method that could acquire several orders of quantum coherence during the same acquisition. This would enable comparison of the image contrast for various orders and eliminate image coregistration problems between scans. It has previously been demonstrated that multiple orders of iMQC images can be simultaneously acquired of a simple phantom. Here, we examine the technique and its effect on biological tissue, both in vivo and in vitro. First, we establish the effectiveness of the iMQC sequence in vivo using earthworms as specimens. We then further show that the multi-CRAZED sequence enhances detection of next generation (nanoparticle) contrast agents on excised tumor tissue.

journal_name

Magn Reson Imaging

journal_title

Magnetic resonance imaging

authors

Shannon KL,Branca RT,Galiana G,Cenzano S,Bouchard LS,Soboyejo W,Warren WS

doi

10.1016/j.mri.2004.10.019

subject

Has Abstract

pub_date

2004-12-01 00:00:00

pages

1407-12

issue

10

eissn

0730-725X

issn

1873-5894

pii

S0730-725X(04)00308-X

journal_volume

22

pub_type

杂志文章

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