当前位置： SCI文献检索 > MAGNETIC RESONANCE IMAGING期刊下所有文献 > Magnetic resonance in the era of molecular imaging of cancer.

Magnetic resonance in the era of molecular imaging of cancer.

Abstract：

:Magnetic resonance imaging (MRI) has played an important role in the diagnosis and management of cancer since it was first developed, but other modalities also continue to advance and provide complementary information on the status of tumors. In the future, there will be a major continuing role for noninvasive imaging in order to obtain information on the location and extent of cancer, as well as assessments of tissue characteristics that can monitor and predict treatment response and guide patient management. Developments are currently being undertaken that aim to provide improved imaging methods for the detection and evaluation of tumors, for identifying important characteristics of tumors such as the expression levels of cell surface receptors that may dictate what types of therapy will be effective and for evaluating their response to treatments. Molecular imaging techniques based mainly on radionuclide imaging can depict numerous, specific, cellular and molecular markers of disease and have unique potential to address important clinical and research challenges. In this review, we consider what continuing and evolving roles will be played by MRI in this era of molecular imaging. We discuss some of the challenges for MRI of detecting imaging agents that report on molecular events, but highlight also the ability of MRI to assess other features such as cell density, blood flow and metabolism which are not specific hallmarks of cancer but which reflect molecular changes. We discuss the future role of MRI in cancer and describe the use of selected quantitative imaging techniques for characterizing tumors that can be translated to clinical applications, particularly in the context of evaluating novel treatments.

journal_name

Magn Reson Imaging

journal_title

Magnetic resonance imaging

authors

Gore JC,Manning HC,Quarles CC,Waddell KW,Yankeelov TE

doi

10.1016/j.mri.2011.02.003

subject

Has Abstract

pub_date

2011-06-01 00:00:00

pages

587-600

issue

5

eissn

0730-725X

issn

1873-5894

pii

S0730-725X(11)00065-8

journal_volume

29

pub_type

杂志文章,评审

相关文献

MAGNETIC RESONANCE IMAGING文献大全
  • Analysis of time reduction methods for magnetic resonance elastography of the brain.

    abstract：:Magnetic resonance elastography (MRE) uses a phase-contrast MRI technique to image shear wave propagation in tissue followed by the mathematical inversion of the equations of motion governing tissue mechanics to noninvasively image tissue stiffness. This work investigates the impact of various MR sampling strategies d...

    journal_title：Magnetic resonance imaging

    pub_type： 杂志文章

    doi：10.1016/j.mri.2010.06.016

    authors： Murphy MC,Glaser KJ,Manduca A,Felmlee JP,Huston J 3rd,Ehman RL

    更新日期：2010-12-01 00:00:00

  • Application of fuzzy c-means segmentation technique for tissue differentiation in MR images of a hemorrhagic glioblastoma multiforme.

    abstract：:The application of a raw data-based, operator-independent MR segmentation technique to differentiate boundaries of tumor from edema or hemorrhage is demonstrated. A case of a glioblastoma multiforme with gross and histopathologic correlation is presented. The MR image data set was segmented into tissue classes based o...

    journal_title：Magnetic resonance imaging

    pub_type： 杂志文章

    doi：10.1016/0730-725x(94)00093-i

    authors： Phillips WE 2nd,Velthuizen RP,Phuphanich S,Hall LO,Clarke LP,Silbiger ML

    更新日期：1995-01-01 00:00:00

  • Sources of functional magnetic resonance imaging signal fluctuations in the human brain at rest: a 7 T study.

    abstract：:Signal fluctuations in functional magnetic resonance imaging (fMRI) can result from a number of sources that may have a neuronal, physiologic or instrumental origin. To determine the relative contribution of these sources, we recorded physiological (respiration and cardiac) signals simultaneously with fMRI in human vo...

    journal_title：Magnetic resonance imaging

    pub_type： 杂志文章

    doi：10.1016/j.mri.2009.02.004

    authors： Bianciardi M,Fukunaga M,van Gelderen P,Horovitz SG,de Zwart JA,Shmueli K,Duyn JH

    更新日期：2009-10-01 00:00:00

  • Intravoxel incoherent imaging of renal fibrosis induced in a murine model of unilateral ureteral obstruction.

    abstract：PURPOSE:To evaluate non-invasive imaging biomarkers for assessing renal fibrosis. DWI is used to assess renal function; intravoxel incoherent motion (IVIM) provides additional measures of perfusion-related diffusion (D*, blood flow; f, perfusion fraction). We aim to determine if reduced ADC seen in renal fibrosis is at...

    journal_title：Magnetic resonance imaging

    pub_type： 杂志文章

    doi：10.1016/j.mri.2015.07.012

    authors： Hennedige T,Koh TS,Hartono S,Yan YY,Song IC,Zheng L,Lee WS,Rumpel H,Martarello L,Khoo JB,Koh DM,Chuang KH,Thng CH

    更新日期：2015-12-01 00:00:00

  • Chiari malformation type I: a new MRI classification.

    abstract：:Thirty patients with Chiari I malformation were examined by MRI over 2-year period. All patients underwent MRI scan before and after surgical decompression of the posterior fossa. Images of the craniocervical junction confirmed tonsillar herniation in all cases and allowed the definition of two anatomically distinct t...

    journal_title：Magnetic resonance imaging

    pub_type： 杂志文章

    doi：10.1016/s0730-725x(96)00383-9

    authors： Amer TA,el-Shmam OM

    更新日期：1997-01-01 00:00:00

  • Inherent spatial structure in myelin water fraction maps.

    abstract：:Myelin water fraction (MWF) images in brain tend to be spatially noisy with unknown or no apparent spatial patterns structure, so values are therefore typically averaged over large white matter (WM) volumes. We investigated the existence of an inherent spatial structure in MWF maps and explored the benefits of examini...

    journal_title：Magnetic resonance imaging

    pub_type： 杂志文章

    doi：10.1016/j.mri.2019.09.012

    authors： Baumeister TR,Kolind SH,MacKay AL,McKeown MJ

    更新日期：2020-04-01 00:00:00

  • Magnetic resonance T2* measurements of the normal human lung in vivo with ultra-short echo times.

    abstract：:The objective of this study was to measure T2* values of the normal human lung in vivo during breathhold using a rapid gradient-echo sequence with ultra-short echo times (TE). A sagittal slice of the right lung was imaged in six volunteers with various TE ranging from 0.5 ms to 5 ms using a clinical 1.5 Tesla MR scann...

    journal_title：Magnetic resonance imaging

    pub_type： 杂志文章

    doi：10.1016/s0730-725x(99)00047-8

    authors： Stock KW,Chen Q,Hatabu H,Edelman RR

    更新日期：1999-09-01 00:00:00

  • Reproducibility of simultaneous imaging of intracranial and extracranial arterial vessel walls using an improved T1-weighted DANTE-SPACE sequence on a 3 T MR system.

    abstract：PURPOSE:To systematically investigate the scan-rescan, intra-observer, and inter-observer reproducibility of an improved DANTE-SPACE sequence for the simultaneous assessment of intra- and extracranial arterial vessel wall morphology. MATERIALS AND METHODS:Thirty-five healthy volunteers and 10 patients with atheroscler...

    journal_title：Magnetic resonance imaging

    pub_type： 杂志文章

    doi：10.1016/j.mri.2019.04.016

    authors： Wan L,Zhang N,Zhang L,Long X,Jia S,Li Y,Liang D,Zheng H,Liu X

    更新日期：2019-10-01 00:00:00

  • Simultaneous imaging of locus coeruleus and substantia nigra with a quantitative neuromelanin MRI approach.

    abstract：:Quantitative MRI of neuromelanin (NM) containing structures (referred to as NM-MRI) in the brainstem, namely the locus coeruleus (LC) and substantia nigra (SN), may assist with the early detection of Parkinson's disease (PD) and Alzheimer's disease (AD) as well as differential diagnosis in the early disease stages. In...

    journal_title：Magnetic resonance imaging

    pub_type： 杂志文章

    doi：10.1016/j.mri.2014.07.003

    authors： Chen X,Huddleston DE,Langley J,Ahn S,Barnum CJ,Factor SA,Levey AI,Hu X

    更新日期：2014-12-01 00:00:00

  • Correction of intensity nonuniformity in MR images of any orientation.

    abstract：:The specialised radiofrequency (RF) coils used in MRI such as head or surface coils can give rise to marked image intensity nonuniformities. There are two situations in which it is essential to correct this: (1) When a global intensity threshold is used to segment particular tissues; and (2) in proton density images, ...

    journal_title：Magnetic resonance imaging

    pub_type： 杂志文章

    doi：10.1016/0730-725x(93)90023-7

    authors： Wicks DA,Barker GJ,Tofts PS

    更新日期：1993-01-01 00:00:00

  • MRI of a retained sponge in a dog.

    abstract：:Retained sponges after laparotomy may cause a broad spectrum of clinical symptoms and present a difficult diagnostic problem. We report a case of retained surgical sponge in a dog to illustrate the MRI findings of this infrequent but important cause of postoperative complications. ...

    journal_title：Magnetic resonance imaging

    pub_type： 杂志文章

    doi：10.1016/0730-725x(85)90358-3

    authors： Terrier F,Revel D,Hricak H,Feduska N

    更新日期：1985-01-01 00:00:00

  • Liposomal Gd-DTPA: effect of encapsulation on enhancement of hepatoma model by MRI.

    abstract：:Liposomes entrapping gadolinium-DTPA (Gd-DTPA) were synthesized from 60 mole percent egg phosphatidylcholine (EPC) and 40 mole percent cholesterol or EPC alone entrapping Gd-DTPA in diameters of 100 and 200 nm. Rats bearing Morris hepatoma in their flanks were imaged by MR pre- and post-contrast with free Gd-DTPA and ...

    journal_title：Magnetic resonance imaging

    pub_type： 杂志文章

    doi：10.1016/0730-725x(89)90491-8

    authors： Unger EC,MacDougall P,Cullis P,Tilcock C

    更新日期：1989-07-01 00:00:00

  • Echo-shifted multislice EPI for high-speed fMRI.

    abstract：:The advantages of event-related functional Magnetic Resonance Imaging (fMRI) and the increasing use of fMRI in cognitive experiments are both driving the development of techniques that allow images sensitive to the blood oxygen level-dependent effect to be acquired at ever-higher temporal resolution. Here, we present ...

    journal_title：Magnetic resonance imaging

    pub_type： 杂志文章

    doi：10.1016/j.mri.2005.12.030

    authors： Gibson A,Peters AM,Bowtell R

    更新日期：2006-05-01 00:00:00

  • Predictability of SNR and reader preference in clinical MR imaging.

    abstract：:Fifty-four independent scans were performed in two volunteers covering one anatomic region in each (the brain and knee) with the purpose of ascertaining the agreement between predicted and measured signal-to-noise ratios (SNR). Systematically varied parameters were number of excitations (NEX), field of view (FOV), sec...

    journal_title：Magnetic resonance imaging

    pub_type： 杂志文章

    doi：10.1016/0730-725x(90)90009-q

    authors： Owen RS,Wehrli FW

    更新日期：1990-01-01 00:00:00

  • Primary epiploic appendagitis: MRI findings.

    abstract：:Primary epiploic appendagitis (PEA) occurs secondary to inflammation of an epiploic appendage, and is considered to be a rare cause of acute abdomen. In this case report, we describe the magnetic resonance imaging (MRI) findings of PEA correlated with computed tomographic (CT) findings. MRI findings included an oval s...

    journal_title：Magnetic resonance imaging

    pub_type： 杂志文章

    doi：10.1016/s0730-725x(02)00478-2

    authors： Sirvanci M,Balci NC,Karaman K,Duran C,Karakaş E

    更新日期：2002-01-01 00:00:00

  • Gadolinium-enhanced magnetic resonance angiography of renal transplants.

    abstract：:Our purpose was to investigate three-dimensional (3D) gadolinium-enhanced magnetic resonance angiography (Gd-MRA) in the evaluation of renal transplant arteries. Eleven MR angiography examinations were performed in nine renal transplant patients. Gd-MRA, three-dimensional phase contrast (3D-PC) post-gadolinium, and tw...

    journal_title：Magnetic resonance imaging

    pub_type： 杂志文章

    doi：10.1016/s0730-725x(96)00348-7

    authors： Johnson DB,Lerner CA,Prince MR,Kazanjian SN,Narasimham DL,Leichtman AB,Cho KJ

    更新日期：1997-01-01 00:00:00

  • Gd-EOB-DTPA-enhanced-MR imaging in the inflammation stage of nonalcoholic steatohepatitis (NASH) in mice.

    abstract：OBJECTIVE:The purpose of this study is to investigate the correlation between the liver kinetics of gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid (Gd-EOB-DTPA) and liver histopathology in a mouse model of NASH by using dynamic contrast-enhanced MRI. MATERIALS AND METHODS:Twenty male C57/BL6 mice aged 8we...

    journal_title：Magnetic resonance imaging

    pub_type： 杂志文章

    doi：10.1016/j.mri.2016.03.009

    authors： Yamada T,Obata A,Kashiwagi Y,Rokugawa T,Matsushima S,Hamada T,Watabe H,Abe K

    更新日期：2016-07-01 00:00:00

  • Glutamate quantification by PRESS or MEGA-PRESS: Validation, repeatability, and concordance.

    abstract：PURPOSE:While PRESS is often employed to measure glutamate concentrations, MEGA-PRESS enables simultaneous Glx (glutamate and glutamine) and GABA measurements. This study aimed to compare validation, repeatability, and concordance of different approaches for glutamate quantification at 3T to aid future studies in their...

    journal_title：Magnetic resonance imaging

    pub_type： 杂志文章

    doi：10.1016/j.mri.2017.12.029

    authors： van Veenendaal TM,Backes WH,van Bussel FCG,Edden RAE,Puts NAJ,Aldenkamp AP,Jansen JFA

    更新日期：2018-05-01 00:00:00

  • Tissue sodium concentration and sodium T1 mapping of the human brain at 3 T using a Variable Flip Angle method.

    abstract：PURPOSE:The state-of-the-art method to quantify sodium concentrations in vivo consists in a fully relaxed 3D spin-density (SD) weighted acquisition. Nevertheless, most sodium MRI clinical studies use short-TR SD acquisitions to reduce acquisition durations. We present a clinically viable implementation of the Variable ...

    journal_title：Magnetic resonance imaging

    pub_type： 杂志文章

    doi：10.1016/j.mri.2019.01.015

    authors： Coste A,Boumezbeur F,Vignaud A,Madelin G,Reetz K,Le Bihan D,Rabrait-Lerman C,Romanzetti S

    更新日期：2019-05-01 00:00:00

  • Initial changes of non-traumatic osteonecrosis of femoral head in fat suppression images: bone marrow edema was not found before the appearance of band patterns.

    abstract：:The present study examined initial changes in non-traumatic osteonecrosis of the femoral head (ONF) on T1- and T2-weighted MR images, and fat suppression images. The subjects were 57 renal transplant recipients (37 males and 20 females), whose median age at the time of transplantation was 31.5 years old (range, 10 to ...

    journal_title：Magnetic resonance imaging

    pub_type： 杂志文章

    doi：10.1016/s0730-725x(01)00424-6

    authors： Fujioka M,Kubo T,Nakamura F,Shibatani M,Ueshima K,Hamaguchi H,Inoue S,Sugano N,Sakai T,Torii Y,Hasegawa Y,Hirasawa Y

    更新日期：2001-09-01 00:00:00

  • Assessment of cardiac iron by MRI susceptometry and R2* in patients with thalassemia.

    abstract：:A magnetic resonance imaging cardiac magnetic susceptometry (MRI-CS) technique for assessing cardiac tissue iron concentration based on phase mapping was developed. Normal control subjects (n=9) and thalassemia patients (n=13) receiving long-term blood transfusion therapy underwent MRI-CS and MRI measurements of the c...

    journal_title：Magnetic resonance imaging

    pub_type： 杂志文章

    doi：10.1016/j.mri.2009.12.001

    authors： Wang ZJ,Fischer R,Chu Z,Mahoney DH Jr,Mueller BU,Muthupillai R,James EB,Krishnamurthy R,Chung T,Padua E,Vichinsky E,Harmatz P

    更新日期：2010-04-01 00:00:00

  • The study of heat stress in tomato fruits by NMR microimaging.

    abstract：:The ripening of the tomato fruit was delayed for several days (average 5 days) by a 1-day heat treatment at 42 degrees C. Ethylene production increased during the first 3 h, but, after 6 h inhibition was almost total in tomato fruit incubated at 42 degrees C. However, recovery of ethylene production was rapid if fruit...

    journal_title：Magnetic resonance imaging

    pub_type： 杂志文章

    doi：10.1016/s0730-725x(98)00219-7

    authors： Iwahashi Y,Horigane AK,Yoza K,Nagata T,Hosoda H

    更新日期：1999-06-01 00:00:00

  • In vivo mapping of functional domains and axonal connectivity in cat visual cortex using magnetic resonance imaging.

    abstract：:Noninvasive cognitive neuroimaging studies based on functional magnetic resonance imaging (fMRI) are of ever-increasing importance for basic and clinical neurosciences. The explanatory power of fMRI could be greatly expanded, however, if the pattern of the neuronal circuitry underlying functional activation could be m...

    journal_title：Magnetic resonance imaging

    pub_type： 杂志文章

    doi：10.1016/j.mri.2003.08.014

    authors： Kim DS,Kim M,Ronen I,Formisano E,Kim KH,Ugurbil K,Mori S,Goebel R

    更新日期：2003-12-01 00:00:00

  • MRI-assisted radiation therapy planning of brain tumors--clinical experiences in 17 patients.

    abstract：:A new and simple method for precise determination of lateral opposed treatment portals was developed and used in 17 patients. Compared to CT, MRI led to significant changes of portals in 59% (10/17) of cases. Individual shielding blocks could be precisely designed by use of our new method. MRI is the procedure of choi...

    journal_title：Magnetic resonance imaging

    pub_type： 杂志文章

    doi：10.1016/0730-725x(91)90007-9

    authors： Just M,Rösler HP,Higer HP,Kutzner J,Thelen M

    更新日期：1991-01-01 00:00:00

  • Measurements of RF heating during 3.0-T MRI of a pig implanted with deep brain stimulator.

    abstract：PURPOSE:To present preliminary, in vivo temperature measurements during MRI of a pig implanted with a deep brain stimulation (DBS) system. MATERIALS AND METHODS:DBS system (Medtronic Inc., Minneapolis, MN) was implanted in the brain of an anesthetized pig. 3.0-T MRI was performed with a T/R head coil using the low-SAR...

    journal_title：Magnetic resonance imaging

    pub_type： 杂志文章

    doi：10.1016/j.mri.2012.11.005

    authors： Gorny KR,Presti MF,Goerss SJ,Hwang SC,Jang DP,Kim I,Min HK,Shu Y,Favazza CP,Lee KH,Bernstein MA

    更新日期：2013-06-01 00:00:00

  • Synovial sarcoma: MR imaging.

    abstract：:Ten patients with biopsy-proved synovial sarcoma were evaluated by magnetic resonance (MR) imaging on a 1.5-T unit. The lesions showed intermediate signal intensity on T1-weighted images and heterogeneous high signal intensity on T2-weighted images. Tumors were well-demarcated from normal tissues. Additional informati...

    journal_title：Magnetic resonance imaging

    pub_type： 杂志文章

    doi：10.1016/0730-725x(89)90706-6

    authors： Mahajan H,Lorigan JG,Shirkhoda A

    更新日期：1989-03-01 00:00:00

  • Automated classification of multispectral MR images using unsupervised constrained energy minimization based on fuzzy logic.

    abstract：:Constrained energy minimization (CEM) has proven highly effective for hyperspectral (or multispectral) target detection and classification. It requires a complete knowledge of the desired target signature in images. This work presents "Unsupervised CEM (UCEM)," a novel approach to automatically target detection and cl...

    journal_title：Magnetic resonance imaging

    pub_type： 杂志文章

    doi：10.1016/j.mri.2010.03.009

    authors： Lin GC,Wang CM,Wang WJ,Sun SY

    更新日期：2010-06-01 00:00:00

  • Study of normal breast tissue by in vivo volume localized proton MR spectroscopy: variation of water-fat ratio in relation to the heterogeneity of the breast and the menstrual cycle.

    abstract：PURPOSE:To investigate the alterations in water-fat (W-F) ratio of the normal breast tissue of female volunteers as a function of the histological phases of the menstrual cycle. METHODS:Image-guided volume localized in vivo proton ((1)H) magnetic resonance spectroscopy (MRS) at 1.5 T was carried out in the para-areola...

    journal_title：Magnetic resonance imaging

    pub_type： 杂志文章

    doi：10.1016/j.mri.2009.01.004

    authors： Sharma U,Kumar M,Sah RG,Jagannathan NR

    更新日期：2009-07-01 00:00:00

  • Application of magnetic resonance imaging to the measurement of neurodegeneration in rat brain: MRI data correlate strongly with histology and enzymatic analysis.

    abstract：:Focal brain ischemia was induced by middle cerebral artery occlusion in the rat. The volume of cerebral damage was determined 2 days later by MRI in vivo and in the same animals histologically. The edema volume as measured by MRI and the histologically determined infarction was highly correlated. As a consequence, the...

    journal_title：Magnetic resonance imaging

    pub_type： 杂志文章

    doi：10.1016/0730-725x(92)90411-r

    authors： Allegrini PR,Sauer D

    更新日期：1992-01-01 00:00:00

  • GRAPPA-based susceptibility-weighted imaging of normal volunteers and patients with brain tumor at 7 T.

    abstract：:Susceptibility-weighted imaging (SWI) is a valuable technique for high-resolution imaging of brain vasculature that greatly benefits from the emergence of higher field strength MR scanners. Autocalibrating partially parallel imaging techniques can be employed to reduce lengthy acquisition times as long as the decrease...

    journal_title：Magnetic resonance imaging

    pub_type： 杂志文章

    doi：10.1016/j.mri.2008.08.003

    authors： Lupo JM,Banerjee S,Hammond KE,Kelley DA,Xu D,Chang SM,Vigneron DB,Majumdar S,Nelson SJ

    更新日期：2009-05-01 00:00:00