GRAPPA-based susceptibility-weighted imaging of normal volunteers and patients with brain tumor at 7 T.

Abstract:

:Susceptibility-weighted imaging (SWI) is a valuable technique for high-resolution imaging of brain vasculature that greatly benefits from the emergence of higher field strength MR scanners. Autocalibrating partially parallel imaging techniques can be employed to reduce lengthy acquisition times as long as the decrease in signal-to-noise ratio does not significantly affect the contrast between vessels and brain parenchyma. This study assessed the feasibility of a Generalized Autocalibrating Partially Parallel Acquisition (GRAPPA)-based SWI technique at 7 T in both healthy volunteers and brain tumor patients. GRAPPA-based SWI allowed a twofold or more reduction in scan time without compromising vessel contrast and small vessel detection. Postprocessing parameters for the SWI needed to be modified for patients where the tumor causes high-frequency phase wrap artifacts but did not adversely affect vessel contrast. GRAPPA-based SWI at 7 T revealed regions of microvascularity, hemorrhage and calcification within heterogeneous brain tumors that may aid in characterizing active or necrotic tumor and monitoring treatment effects.

journal_name

Magn Reson Imaging

authors

Lupo JM,Banerjee S,Hammond KE,Kelley DA,Xu D,Chang SM,Vigneron DB,Majumdar S,Nelson SJ

doi

10.1016/j.mri.2008.08.003

subject

Has Abstract

pub_date

2009-05-01 00:00:00

pages

480-8

issue

4

eissn

0730-725X

issn

1873-5894

pii

S0730-725X(08)00271-3

journal_volume

27

pub_type

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