Abstract：
PURPOSE:To evaluate non-invasive imaging biomarkers for assessing renal fibrosis. DWI is used to assess renal function; intravoxel incoherent motion (IVIM) provides additional measures of perfusion-related diffusion (D*, blood flow; f, perfusion fraction). We aim to determine if reduced ADC seen in renal fibrosis is attributable to perfusion-related diffusion changes or to known reduction in tissue diffusivity (D). MATERIALS AND METHODS:Unilateral ureteral obstruction (UUO) was created in six mice to induce renal fibrosis. DWI was performed the day before and 7 days post-UUO. A range of b-values from 0 to 1200 s/mm(2) were used. IVIM parameters were obtained using region of interests drawn over the renal parenchyma. Histopathological analysis of both kidneys was performed in all mice. Results were analyzed using the paired t-test with P<0.05 considered statistically significant. RESULTS:D and f were significantly lower in the ligated kidneys at Day 7 compared to before ligation and no significant difference was found for D*. Comparing non-ligated and ligated kidneys within the same mouse at Day 7, significantly lower D values were observed in the ligated kidneys, while no significant difference was found for f and D*, although the values of f were generally lower. Histopathological analysis confirmed development of fibrosis and reduction in glomeruli in all the ligated kidneys at Day 7. CONCLUSION:Our study shows that the reduction in ADC seen in renal fibrosis is attributable not only to reduced D as previously encountered but also a decrease in vascularity as assessed by f. Reduction in f is possibly related to a reduction in glomeruli.
journal_name
Magn Reson Imagingjournal_title
Magnetic resonance imagingauthors
Hennedige T,Koh TS,Hartono S,Yan YY,Song IC,Zheng L,Lee WS,Rumpel H,Martarello L,Khoo JB,Koh DM,Chuang KH,Thng CHdoi
10.1016/j.mri.2015.07.012subject
Has Abstractpub_date
2015-12-01 00:00:00pages
1324-1328issue
10eissn
0730-725Xissn
1873-5894pii
S0730-725X(15)00188-5journal_volume
33pub_type
杂志文章abstract：PURPOSE:We present three-dimensional adiabatic inversion recovery prepared ultrashort echo time Cones (3D IR-UTE-Cones) imaging of cortical bone in the hip of healthy volunteers using a clinical 3T scanner. METHODS:A 3D IR-UTE-Cones sequence, based on a short pulse excitation followed by a 3D Cones trajectory, with a ...
journal_title：Magnetic resonance imaging
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doi：10.1016/j.mri.2007.06.008
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journal_title：Magnetic resonance imaging
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更新日期：2018-05-01 00:00:00
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journal_title：Magnetic resonance imaging
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更新日期：2004-05-01 00:00:00
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更新日期：2018-06-01 00:00:00
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journal_title：Magnetic resonance imaging
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doi：10.1016/j.mri.2011.10.005
更新日期：2012-04-01 00:00:00
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doi：10.1016/j.mri.2003.09.005
更新日期：2004-02-01 00:00:00
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更新日期：2006-01-01 00:00:00
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journal_title：Magnetic resonance imaging
pub_type： 杂志文章
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