当前位置： SCI文献检索 > MAGNETIC RESONANCE IMAGING期刊下所有文献 > Preparation, physico-chemical characterization, and relaxometry studies of various gadolinium(III)-DTPA-bis(amide) derivatives as potential magnetic resonance contrast agents.

Preparation, physico-chemical characterization, and relaxometry studies of various gadolinium(III)-DTPA-bis(amide) derivatives as potential magnetic resonance contrast agents.

Abstract：

:Macroscopic protonation constants were measured for a series of DTPA mono- and bis-amide ligands using potentiometric titrations. Proton NMR pH titrations yielded protonation populations of the various nitrogen and oxygen basic sites of the ligands for the different protonation stages. Amide formation decreased the basicity of the backbone nitrogens of the ligands and the thermodynamic stability of the corresponding Gd3+ chelates. Nuclear magnetic relaxation dispersion (NMRD) profiles and ESR linewidths were measured for the Gd3+ chelates. Some of these exhibited an elevated high field relaxivity relative to Gd(DTPA)2-, in response to their high molecular weight. As opposed to Gd(DTPA)2-, at 5 degrees C the chemical exchange process of the single inner-sphere water molecule of the bis-amide complexes becomes so slow that it governs the paramagnetic relaxation process, causing the observed NMRD profiles to be close to those expected for the outer-sphere contribution. The chelates containing long alkyl side chains, such as Gd(DTPA-HPA2), showed increased relaxivity values in the presence of human serum albumin (HSA), indicative of noncovalent interaction with the protein. These chelates could be useful as nonionic hepatobiliary contrast agents.

journal_name

Magn Reson Imaging

journal_title

Magnetic resonance imaging

authors

Geraldes CF,Urbano AM,Alpoim MC,Sherry AD,Kuan KT,Rajagopalan R,Maton F,Muller RN

doi

10.1016/0730-725x(94)00117-l

subject

Has Abstract

pub_date

1995-01-01 00:00:00

pages

401-20

issue

3

eissn

0730-725X

issn

1873-5894

pii

0730-725X(94)00117-L

journal_volume

13

pub_type

杂志文章

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