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Liposomal Gd-DTPA: effect of encapsulation on enhancement of hepatoma model by MRI.

Abstract：

:Liposomes entrapping gadolinium-DTPA (Gd-DTPA) were synthesized from 60 mole percent egg phosphatidylcholine (EPC) and 40 mole percent cholesterol or EPC alone entrapping Gd-DTPA in diameters of 100 and 200 nm. Rats bearing Morris hepatoma in their flanks were imaged by MR pre- and post-contrast with free Gd-DTPA and liposomal Gd-DTPA for up to four hours after IV contrast. Comparison of images after free and liposomal Gd-DTPA showed dramatic differences in tumor and organ enhancement. Liposomal Gd-DTPA enhancement of tumor corresponded more closely to histologically proven vascularized portions of tumor than free Gd-DTPA. Hepatic enhancement was greater with liposomal than free Gd-DTPA and time course of liver, kidney and tumor enhancement was prolonged. The 100-nm EPC Gd-DTPA liposomes caused the greatest enhancement. Gd-DTPA liposomes may be useful as liver and blood pool contrast agents. By varying lipid composition and vesicle size, patterns of enhancement may be selectively modified.

journal_name

Magn Reson Imaging

journal_title

Magnetic resonance imaging

authors

Unger EC,MacDougall P,Cullis P,Tilcock C

doi

10.1016/0730-725x(89)90491-8

subject

Has Abstract

pub_date

1989-07-01 00:00:00

pages

417-23

issue

4

eissn

0730-725X

issn

1873-5894

pii

0730-725X(89)90491-8

journal_volume

7

pub_type

杂志文章

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