Liposomal Gd-DTPA: effect of encapsulation on enhancement of hepatoma model by MRI.


:Liposomes entrapping gadolinium-DTPA (Gd-DTPA) were synthesized from 60 mole percent egg phosphatidylcholine (EPC) and 40 mole percent cholesterol or EPC alone entrapping Gd-DTPA in diameters of 100 and 200 nm. Rats bearing Morris hepatoma in their flanks were imaged by MR pre- and post-contrast with free Gd-DTPA and liposomal Gd-DTPA for up to four hours after IV contrast. Comparison of images after free and liposomal Gd-DTPA showed dramatic differences in tumor and organ enhancement. Liposomal Gd-DTPA enhancement of tumor corresponded more closely to histologically proven vascularized portions of tumor than free Gd-DTPA. Hepatic enhancement was greater with liposomal than free Gd-DTPA and time course of liver, kidney and tumor enhancement was prolonged. The 100-nm EPC Gd-DTPA liposomes caused the greatest enhancement. Gd-DTPA liposomes may be useful as liver and blood pool contrast agents. By varying lipid composition and vesicle size, patterns of enhancement may be selectively modified.


Magn Reson Imaging


Unger EC,MacDougall P,Cullis P,Tilcock C




Has Abstract


1989-07-01 00:00:00














  • Relationship between cancellous bone induced magnetic field and ultrastructure in a rat ovariectomy model.

    abstract::The site-dependent variations in trabecular bone morphology were studied in the rat tibia by magnitude and phase difference three-dimensional nuclear magnetic resonance microscopy and image processing, and the implications of ovariectomy were evaluated. Specimens excised from the proximal tibial metaphysis in ovariect...

    journal_title:Magnetic resonance imaging

    pub_type: 杂志文章


    authors: Takahashi M,Wehrli FW,Hwang SN,Wehrli SL

    更新日期:2000-01-01 00:00:00

  • Quantitative determination of porosity: a local assessment by NMR imaging techniques.

    abstract::The local determination of porosity is an extremely valuable target because of different applications in petrophysics. In fact, obtaining a reliable profile of porosity or saturations could considerably improve the evaluation of transport properties of porous media, especially if applied to multiphase flow test (i.e.,...

    journal_title:Magnetic resonance imaging

    pub_type: 杂志文章


    authors: Borgia GC,Bortolotti V,Dattilo P,Fantazzini P,Maddinelli G

    更新日期:1996-01-01 00:00:00

  • The reliability of routine clinical post-processing software in assessing potential diffusion-weighted MRI "biomarkers" in brain metastases.

    abstract:BACKGROUND AND PURPOSE:Diffusion MRI characteristics have been used as biomarkers to guide prognosis in cerebral pathologies including brain metastases. The measurement of ADC is often described poorly in clinical and research studies with little detail given to the practical considerations of where to place ROIs, whic...

    journal_title:Magnetic resonance imaging

    pub_type: 杂志文章


    authors: Zakaria R,Das K,Bhojak M,Radon M,Sluming V,Walker C,Jenkinson MD

    更新日期:2014-04-01 00:00:00

  • Increasing mean airway pressure reduces functional MRI (fMRI) signal in the primary visual cortex.

    abstract::Changes in both blood flow and blood oxygenation determine the functional MRI (fMRI) signal. In the present study factors responsible for blood oxygenation (e.g., FiO(2)) were held constant so that changes in pixel count would above all reflect changes in regional cerebral blood flow (rCBF). Continuous positive airway...

    journal_title:Magnetic resonance imaging

    pub_type: 杂志文章


    authors: Lorenz IH,Kolbitsch C,Hörmann C,Schocke M,Kremser C,Zschiegner F,Felber S,Benzer A

    更新日期:2001-01-01 00:00:00

  • 1H magnetic resonance imaging and 31P magnetic resonance spectroscopy in experimental filariasis.

    abstract::1H Magnetic resonance imaging and 31P magnetic resonance spectroscopy (MRS) have been carried out in experimental rodent filariasis, i.e., Acanthocheilonema viteae infection in the rodent host, Mastomys coucha. The T2-weighted image of the infected host shows fine hyperintense thread like structures of adult filariid ...

    journal_title:Magnetic resonance imaging

    pub_type: 杂志文章


    authors: Shukla-Dave A,Fatma N,Roy R,Srivastava S,Chatterjee RK,Govindaraju V,Viswanathan AK,Raghunathan P

    更新日期:1997-01-01 00:00:00

  • The Langerhans' cell histiocytosis (eosinophilic granuloma) of the cervical spine: a rare diagnosis of cervical pain.

    abstract::We present the case of a 44-year-old man who complained of cervical pain. He was treated with physiotherapy and analgetics. Because of persistent pain, computed tomography (CT) scan and MRI were performed. They revealed an osteolytic destruction of the fourth cervical vertebra. The patient was treated surgically for r...

    journal_title:Magnetic resonance imaging

    pub_type: 杂志文章,评审


    authors: Simanski C,Bouillon B,Brockmann M,Tiling T

    更新日期:2004-05-01 00:00:00

  • A method for MR quantification of flow velocities in blood and CSF using interleaved gradient-echo pulse sequences.

    abstract::The aim of this study was to establish a rapid method for in vivo quantification of a large range of flow velocities using phase information. A basic gradient-echo sequence was constructed, in which flow was encoded along the slice selection direction by variation of the amplitude of a bipolar gradient without changes...

    journal_title:Magnetic resonance imaging

    pub_type: 杂志文章


    authors: Ståhlberg F,Mogelvang J,Thomsen C,Nordell B,Stubgaard M,Ericsson A,Sperber G,Greitz D,Larsson H,Henriksen O

    更新日期:1989-11-01 00:00:00

  • Imaging of HDR brachytherapy dose distributions using NMR Fricke-gelatin dosimetry.

    abstract::The application of NMR Fricke-gelatin dosimetry to the imaging of dose distributions around high dose rate (HDR) radioactive Ir-192 seeds in brachytherapy is presented. The duration of the irradiations required to give changes of the Fricke-gelatin NMR characteristics, which were readily detected by the magnetic reson...

    journal_title:Magnetic resonance imaging

    pub_type: 杂志文章


    authors: Schreiner LJ,Crooks I,Evans MD,Keller BM,Parker WA

    更新日期:1994-01-01 00:00:00

  • Surface magnetic relaxation in cement pastes.

    abstract::Surface magnetic relaxation in porous media is usually attributed to hindered rotation or to paramagnetic impurities on the surface. In cement pastes, however, it seems reasonable to attribute surface relaxation to dipole interactions in water adsorbed as water of hydration on grain surfaces. The rate limiting factor ...

    journal_title:Magnetic resonance imaging

    pub_type: 杂志文章


    authors: Mendelson KS,Halperin WP,Jehng JY,Song YQ

    更新日期:1994-01-01 00:00:00

  • Effects of 3D sampling in (k, t)-space on temporal qualities of dynamic MRI.

    abstract::3D (kx, ky, t)-space analysis is invoked to provide insights into dynamic magnetic resonance imaging (DMRI) with arbitrary k-space sampling trajectories. The effects of 3D sampling in (kx, ky, t) are analyzed theoretically and verified with computer simulation. The analyses show that a 3D sampling pattern that is more...

    journal_title:Magnetic resonance imaging

    pub_type: 杂志文章


    authors: Park JB,Nishimura DG

    更新日期:2006-10-01 00:00:00

  • Electric stimulation fMRI of the perforant pathway to the rat hippocampus.

    abstract::The hippocampal formation is a brain system that is implicated in learning and memory. The major input to the hippocampus arrives from the entorhinal cortex (EC) to the dentate gyrus (DG) through the perforant path. In the present work, we have investigated the functional properties of this connection by concomitantly...

    journal_title:Magnetic resonance imaging

    pub_type: 杂志文章


    authors: Canals S,Beyerlein M,Murayama Y,Logothetis NK

    更新日期:2008-09-01 00:00:00

  • Neural activity-induced modulation of BOLD poststimulus undershoot independent of the positive signal.

    abstract::Despite intense research on the blood oxygenation level-dependent (BOLD) signal underlying functional magnetic resonance imaging, our understanding of its physiological basis is far from complete. In this study, it was investigated whether the so-called poststimulus BOLD signal undershoot is solely a passive vascular ...

    journal_title:Magnetic resonance imaging

    pub_type: 杂志文章


    authors: Sadaghiani S,Uğurbil K,Uludağ K

    更新日期:2009-10-01 00:00:00

  • The application of NMR imaging to the studies of enhanced oil recovery in China.

    abstract::The advantages of the application of NMR imaging to the studies of enhanced oil recovery methods that include polymer slug flooding, combination slug flooding, and thermal soaking are described. ...

    journal_title:Magnetic resonance imaging

    pub_type: 杂志文章


    authors: Weimin W,Dongjiang L,Wei L

    更新日期:1996-01-01 00:00:00

  • An alternative viewpoint of the similarities and differences of SVD and FT deconvolution algorithms used for quantitative MR perfusion studies.

    abstract::Quantitative cerebral blood flow (CBF) values can be determined from residue function estimates obtained from magnetic resonance dynamic susceptibility contrast (DSC) perfusion studies using a variety of deconvolution approaches. However, there are significant differences between the CBF estimates obtained, difference...

    journal_title:Magnetic resonance imaging

    pub_type: 杂志文章


    authors: Salluzzi M,Frayne R,Smith MR

    更新日期:2005-04-01 00:00:00

  • Influence of cholecystectomy on the flow dynamic pattern of bile in the extrahepatic bile duct: Assessment by cine-dynamic MRCP with spatially-selective IR pulse.

    abstract:PURPOSE:To evaluate the influence of cholecystectomy on the flow dynamic pattern of bile in the extrahepatic bile duct by using cine-dynamic MRCP with spatially-selective inversion-recovery (IR) pulse non-invasively. MATERIALS AND METHODS:56 patients with cholecystectomy and 48 control subjects without cholecystectomy...

    journal_title:Magnetic resonance imaging

    pub_type: 杂志文章


    authors: Sotozono H,Tamada T,Kanki A,Yasokawa K,Fukunaga T,Yamamoto A,Ito K

    更新日期:2020-12-01 00:00:00

  • Automated measurement of fat infiltration in the hip abductors from Dixon magnetic resonance imaging.

    abstract:PURPOSE:Intramuscular fat infiltration is a dynamic process, in response to exercise and muscle health, which can be quantified by estimating fat fraction (FF) from Dixon MRI. Healthy hip abductor muscles are a good indicator of a healthy hip and an active lifestyle as they have a fundamental role in walking. The autom...

    journal_title:Magnetic resonance imaging

    pub_type: 杂志文章


    authors: Belzunce MA,Henckel J,Fotiadou A,Di Laura A,Hart A

    更新日期:2020-10-01 00:00:00

  • Functional evaluation of normal and ischemic kidney by means of gadolinium-DOTA enhanced TurboFLASH MR imaging: a preliminary comparison with 99Tc-MAG3 dynamic scintigraphy.

    abstract::The functional value of TurboFLASH MR imaging in the assessment of dynamic contrast enhancement and renal perfusion anomalies was evaluated in seven patients, who also underwent renal scintigraphy in baseline conditions. The basal renograms obtained from MAG-3 scintigraphy (mercapto acetyl triglycine, MAG3-S) and from...

    journal_title:Magnetic resonance imaging

    pub_type: 杂志文章


    authors: Laissy JP,Faraggi M,Lebtahi R,Soyer P,Brillet G,Méry JP,Menu Y,Le Guludec D

    更新日期:1994-01-01 00:00:00

  • Reproducibility of simultaneous imaging of intracranial and extracranial arterial vessel walls using an improved T1-weighted DANTE-SPACE sequence on a 3 T MR system.

    abstract:PURPOSE:To systematically investigate the scan-rescan, intra-observer, and inter-observer reproducibility of an improved DANTE-SPACE sequence for the simultaneous assessment of intra- and extracranial arterial vessel wall morphology. MATERIALS AND METHODS:Thirty-five healthy volunteers and 10 patients with atheroscler...

    journal_title:Magnetic resonance imaging

    pub_type: 杂志文章


    authors: Wan L,Zhang N,Zhang L,Long X,Jia S,Li Y,Liang D,Zheng H,Liu X

    更新日期:2019-10-01 00:00:00

  • Differentiation of hepatic cavernous hemangioma from metastases by rare sequence MR imaging.

    abstract::In this study, in order to differentiate cavernous hemangioma and hepatic metastases, rapid acquisition relaxation enhanced (RARE) sequence was used. First, in vivo measurements of T1, T2 relaxation times and proton density were obtained using T1, T2 calculation protocol (TOMIKON S50, 0.5T) and multipoint techniques. ...

    journal_title:Magnetic resonance imaging

    pub_type: 杂志文章


    authors: Jafari F,Nayeri N,Tahsini M,Khodadoust AA

    更新日期:1999-06-01 00:00:00

  • Measurements of RF heating during 3.0-T MRI of a pig implanted with deep brain stimulator.

    abstract:PURPOSE:To present preliminary, in vivo temperature measurements during MRI of a pig implanted with a deep brain stimulation (DBS) system. MATERIALS AND METHODS:DBS system (Medtronic Inc., Minneapolis, MN) was implanted in the brain of an anesthetized pig. 3.0-T MRI was performed with a T/R head coil using the low-SAR...

    journal_title:Magnetic resonance imaging

    pub_type: 杂志文章


    authors: Gorny KR,Presti MF,Goerss SJ,Hwang SC,Jang DP,Kim I,Min HK,Shu Y,Favazza CP,Lee KH,Bernstein MA

    更新日期:2013-06-01 00:00:00

  • Anisotropic diffusion in etched particle tracks studied by field gradient NMR.

    abstract::Etched particle tracks produced after heavy ion irradiation of polymer foils are used as model systems to test the performance of NMR in a newly developed ultrahigh magnetic field gradient system. The stimulated NMR echo decay of molecules diffusing in the channels, formulated in terms of the self part of the intermed...

    journal_title:Magnetic resonance imaging

    pub_type: 杂志文章


    authors: Fujara F,Ilyina E,Nienstaedt H,Sillescu H,Spohr R,Trautmann C

    更新日期:1994-01-01 00:00:00

  • Adaptive total linear least square method for quantification of mean transit time in brain perfusion MRI.

    abstract::Absolute quantification of cerebral blood flow (CBF), cerebral blood volume (CBV), and mean transit time (MTT) are of great relevance for clinical applications. One of the widely used methods for quantification of these parameters is gamma-variate fitting. Traditional nonlinear regression methods for gamma-variate fit...

    journal_title:Magnetic resonance imaging

    pub_type: 杂志文章


    authors: Li X,Tian J,Li E,Wang X,Dai J,Ai L

    更新日期:2003-06-01 00:00:00

  • An intravascular loopless monopole antenna for vessel wall MR imaging at 3.0 T.

    abstract::The purpose of this study was to develop a novel intravascular loopless monopole antenna (ILMA) design specifically for imaging of small vessel walls. The ILMA consisted of an unshielded, low-friction guide wire and a tuning/matching box. The material of the guide wire was nitinol and it was coated with polyurethane. ...

    journal_title:Magnetic resonance imaging

    pub_type: 杂志文章


    authors: Yuan H,Lv X,Ma X,Zhang R,Fu Y,Yang X,Wang X,Zhang Z,Zhang J,Fang J

    更新日期:2013-01-01 00:00:00

  • esfMRI of the upper STS: further evidence for the lack of electrically induced polysynaptic propagation of activity in the neocortex.

    abstract::Combining electrical stimulation with fMRI (esfMRI) has proven to be an important tool to study the global effects of electrical stimulation on neural networks in the brain. Here we extend our previous studies to stimulating the upper superior temporal sulcus (STS) in the anesthetized monkey. Our results show that sti...

    journal_title:Magnetic resonance imaging

    pub_type: 杂志文章


    authors: Sultan F,Augath M,Murayama Y,Tolias AS,Logothetis N

    更新日期:2011-12-01 00:00:00

  • Chiari malformation type I: a new MRI classification.

    abstract::Thirty patients with Chiari I malformation were examined by MRI over 2-year period. All patients underwent MRI scan before and after surgical decompression of the posterior fossa. Images of the craniocervical junction confirmed tonsillar herniation in all cases and allowed the definition of two anatomically distinct t...

    journal_title:Magnetic resonance imaging

    pub_type: 杂志文章


    authors: Amer TA,el-Shmam OM

    更新日期:1997-01-01 00:00:00

  • Three-dimensional adiabatic inversion recovery prepared ultrashort echo time cones (3D IR-UTE-Cones) imaging of cortical bone in the hip.

    abstract:PURPOSE:We present three-dimensional adiabatic inversion recovery prepared ultrashort echo time Cones (3D IR-UTE-Cones) imaging of cortical bone in the hip of healthy volunteers using a clinical 3T scanner. METHODS:A 3D IR-UTE-Cones sequence, based on a short pulse excitation followed by a 3D Cones trajectory, with a ...

    journal_title:Magnetic resonance imaging

    pub_type: 杂志文章


    authors: Nazaran A,Carl M,Ma Y,Jerban S,Zhu Y,Lu X,Du J,Chang EY

    更新日期:2017-12-01 00:00:00

  • Combination of integrated dynamic shimming and readout-segmented echo planar imaging for diffusion weighted MRI of the head and neck region at 3Tesla.

    abstract:PURPOSE:To evaluate the performance of combined integrated slice-by-slice shimming and readout-segmented EPI (irsEPI) for diffusion-weighted MR imaging (DWI) of the neck at 3Tesla. METHODS:This study was approved by the local ethics committee. An anthropometric phantom of the head/neck region incorporating compartment...

    journal_title:Magnetic resonance imaging

    pub_type: 杂志文章


    authors: Walter SS,Liu W,Stemmer A,Martirosian P,Nikolaou K,Notohamiprodjo M,Gatidis S

    更新日期:2017-10-01 00:00:00

  • Empirical optimization of ASL data analysis using an ASL data processing toolbox: ASLtbx.

    abstract::Arterial spin labeling (ASL) perfusion fMRI data differ in important respects from the more familiar blood oxygen level-dependent (BOLD) fMRI data and require specific processing strategies. In this paper, we examined several factors that may influence ASL data analysis, including data storage bit resolution, motion c...

    journal_title:Magnetic resonance imaging

    pub_type: 杂志文章


    authors: Wang Z,Aguirre GK,Rao H,Wang J,Fernández-Seara MA,Childress AR,Detre JA

    更新日期:2008-02-01 00:00:00

  • In vivo magnetic resonance study of the histochemistry of coconut (Cocos nucifera).

    abstract::Magnetic resonance imaging (MRI) and localized proton MR spectroscopy (MRS) techniques have been applied for studying different maturation processes in the histochemistry of coconut (Cocos nucifera). Images of the tender and mature coconut are characterized by protons of the aqueous solution present in the cavity and ...

    journal_title:Magnetic resonance imaging

    pub_type: 杂志文章


    authors: Jagannathan NR,Govindaraju V,Raghunathan P

    更新日期:1995-01-01 00:00:00

  • Dual-acquisition phase-sensitive fat-water separation using balanced steady-state free precession.

    abstract::Balanced steady-state free precession (SSFP) sequences use fully re-focussed gradient waveforms to achieve a high signal and useful image contrast in short scan times. Despite these strengths, the clinical feasibility of balanced SSFP is still limited both by bright fat signal and by the signal voids that result from ...

    journal_title:Magnetic resonance imaging

    pub_type: 杂志文章


    authors: Hargreaves BA,Bangerter NK,Shimakawa A,Vasanawala SS,Brittain JH,Nishimura DG

    更新日期:2006-02-01 00:00:00