Assessment of cardiac iron by MRI susceptometry and R2* in patients with thalassemia.

Abstract:

:A magnetic resonance imaging cardiac magnetic susceptometry (MRI-CS) technique for assessing cardiac tissue iron concentration based on phase mapping was developed. Normal control subjects (n=9) and thalassemia patients (n=13) receiving long-term blood transfusion therapy underwent MRI-CS and MRI measurements of the cardiac relaxation rate R2*. Using MRI-CS, subepicardium and subendocardium iron concentrations were quantified exploiting the hemosiderin/ferritin iron specific magnetic susceptibility. The average of subepicardium and subendocardium iron concentrations and R2* of the septum were found to be strongly correlated (r=0.96, P<.0001), and linear regression analysis yielded CIC (microg Fe/g(wet tissue))=(6.4+/-0.4).R2* (septum) (s(-1)) - (120+/-40). The results demonstrated that septal R2* indeed measures cardiac iron level.

journal_name

Magn Reson Imaging

authors

Wang ZJ,Fischer R,Chu Z,Mahoney DH Jr,Mueller BU,Muthupillai R,James EB,Krishnamurthy R,Chung T,Padua E,Vichinsky E,Harmatz P

doi

10.1016/j.mri.2009.12.001

subject

Has Abstract

pub_date

2010-04-01 00:00:00

pages

363-71

issue

3

eissn

0730-725X

issn

1873-5894

pii

S0730-725X(09)00293-8

journal_volume

28

pub_type

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