Abstract：
:Ultra-high field magnetic resonance imaging data obtained using a multi-echo gradient echo sequence has been shown to contain information on tissue microstructure. Quantitative assessment of water fraction, relaxation time and frequency shift using multi-compartment signal modelling may help improve our understanding of diseases and disorders affecting the human brain. In this study, we explored tissue microstructure information by analysing voxel compartment water fraction and frequency shifts derived from 7 T multi-echo gradient recalled echo MRI data. We aimed to test whether the parameters of a three compartment model could distinguish the normal cortex from the cortex affected by focal cortical dysplasia. We compartmentalised normal and dysplastic cortical regions in patients diagnosed with focal cortical dysplasia. We found the frequency shift parameter of the shortest T2⁎ signal compartment to be sensitive to regions of dysplastic tissue. We conclude that mathematical modelling of echo time dependent gradient recalled echo MRI signals in patients with focal cortical dysplasia can potentially delineate cortical areas that have undergone microstructural changes in comparison to normal tissue.
journal_name
Magn Reson Imagingjournal_title
Magnetic resonance imagingauthors
Thapaliya K,Urriola J,Barth M,Reutens DC,Bollmann S,Vegh Vdoi
10.1016/j.mri.2019.05.011subject
Has Abstractpub_date
2019-09-01 00:00:00pages
1-8eissn
0730-725Xissn
1873-5894pii
S0730-725X(18)30651-9journal_volume
61pub_type
杂志文章abstract：:The evaluation of a solitary pulmonary nodule (SPN) is one of the most frequently encountered challenges in thoracic radiology. In addition to a "state-of-the-art" evaluation of SPNs with CT and biopsy techniques, recently the assessment of the enhancement characteristics with iodinized contrast agents has shown its p...
journal_title：Magnetic resonance imaging
pub_type： 杂志文章
doi：10.1016/0730-725x(95)02010-q
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journal_title：Magnetic resonance imaging
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journal_title：Magnetic resonance imaging
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journal_title：Magnetic resonance imaging
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journal_title：Magnetic resonance imaging
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journal_title：Magnetic resonance imaging
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journal_title：Magnetic resonance imaging
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更新日期：2016-07-01 00:00:00
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journal_title：Magnetic resonance imaging
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journal_title：Magnetic resonance imaging
pub_type： 杂志文章
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journal_title：Magnetic resonance imaging
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doi：10.1016/j.mri.2007.07.003
更新日期：2008-02-01 00:00:00
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journal_title：Magnetic resonance imaging
pub_type： 杂志文章
doi：10.1016/j.mri.2008.02.003
更新日期：2008-10-01 00:00:00
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journal_title：Magnetic resonance imaging
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journal_title：Magnetic resonance imaging
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journal_title：Magnetic resonance imaging
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journal_title：Magnetic resonance imaging
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journal_title：Magnetic resonance imaging
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journal_title：Magnetic resonance imaging
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journal_title：Magnetic resonance imaging
pub_type： 杂志文章,评审
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journal_title：Magnetic resonance imaging
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journal_title：Magnetic resonance imaging
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更新日期：2018-01-01 00:00:00
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journal_title：Magnetic resonance imaging
pub_type： 临床试验,杂志文章
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更新日期：2019-10-01 00:00:00
