当前位置： SCI文献检索 > MAGNETIC RESONANCE IMAGING期刊下所有文献 > Comparison of dynamic contrast-enhanced magnetic resonance imaging and contrast-enhanced ultrasound for evaluation of the effects of sorafenib in a rat model of hepatocellular carcinoma.

Comparison of dynamic contrast-enhanced magnetic resonance imaging and contrast-enhanced ultrasound for evaluation of the effects of sorafenib in a rat model of hepatocellular carcinoma.

Abstract：

OBJECTIVES:To compare the accuracy of contrast-enhanced ultrasound (CEUS) and Dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI) for the assessment of changes in tissue vascularization as result of sorafenib treatment in a rat model of hepatocellular carcinoma (HCC). METHODS:Male Buffalo rats with orthotopic liver tumors treated daily with 7.5 mg/kg sorafenib via oral gavage for 2 weeks (n = 9) were subject to DCE-MRI and CEUS 2 weeks after tumor implantation - right before treatment initiation - and also after treatment completion - right before tumor harvest. Untreated animals (n = 10) were used as control. Tumor tissue sections were stained for hematoxylin-eosin, pimonidazole, and CD34 for quantitative assessment of necrosis, hypoxia, and microvessel density (MVD), respectively. RESULTS:Of all the DCE-MRI parameters that were evaluated, only volume transfer constant (Ktrans) measurements were significantly lower in sorafenib-treated tumors (0.18 vs 0.33 min-1, p < 0.01), indicating a substantial decrease in vascular permeability caused by the therapy. This reduction was associated with decreased MVD (3.9 vs 10.8% CD34+ cells, p < 0.01), higher tumor necrosis (31.9 vs 21.8%, p < 0.001) and hypoxia (19.7 vs 10.5% pimonidazole binding, p < 0.01). Moreover, statistical analysis demonstrate significant correlation of DCE-MRI Ktrans with histopathologic tissue necrosis (r = -0.537, p < 0.05) and MVD (r = 0.599, p < 0.05). Interestingly, none of the CEUS measurements were significantly different between the control and treatment groups, and did not show statistical correlation with any of the histopathological parameters assessed (p > 0.05). CONCLUSIONS:Sorafenib-induced reduction in vascular permeability in this preclinical model of HCC is detected more accurately through DCE-MRI than CEUS, and DCE-MRI parameters strongly correlate with histopathological changes in tissue vascularization and tissue necrosis.

journal_name

Magn Reson Imaging

journal_title

Magnetic resonance imaging

authors

Muñoz NM,Minhaj AA,Maldonado KL,Kingsley CV,Cortes AC,Taghavi H,Polak U,Mitchell JM,Ensor JE,Bankson JA,Rashid A,Avritscher R

doi

10.1016/j.mri.2018.11.012

subject

Has Abstract

pub_date

2019-04-01 00:00:00

pages

156-164

eissn

0730-725X

issn

1873-5894

pii

S0730-725X(18)30201-7

journal_volume

57

pub_type

杂志文章

相关文献

MAGNETIC RESONANCE IMAGING文献大全
  • Accuracy and reproducibility of automated white matter hyperintensities segmentation with lesion segmentation tool: A European multi-site 3T study.

    abstract：:Brain vascular damage accumulate in aging and often manifest as white matter hyperintensities (WMHs) on MRI. Despite increased interest in automated methods to segment WMHs, a gold standard has not been achieved and their longitudinal reproducibility has been poorly investigated. The aim of present work is to evaluate...

    journal_title：Magnetic resonance imaging

    pub_type： 杂志文章

    doi：10.1016/j.mri.2020.11.008

    authors： Ribaldi F,Altomare D,Jovicich J,Ferrari C,Picco A,Pizzini FB,Soricelli A,Mega A,Ferretti A,Drevelegas A,Bosch B,Müller BW,Marra C,Cavaliere C,Bartrés-Faz D,Nobili F,Alessandrini F,Barkhof F,Gros-Dagnac H,Ranjeva JP

    更新日期：2021-02-01 00:00:00

  • MR imaging findings in recurrent primary osseous Ewing sarcoma.

    abstract：:The objective of this study was to determine the value of magnetic resonance (MR) imaging in diagnosing local recurrence of Ewing sarcoma. We retrospectively reviewed radiographs, Tc99m-methylene diphosphonate (MDP) skeletal scintigraphy, computed tomography scans, and MR studies of 11 patients who had local recurrenc...

    journal_title：Magnetic resonance imaging

    pub_type： 杂志文章

    doi：10.1016/0730-725x(94)90079-7

    authors： Kauffman WM,Fletcher BD,Hanna SL,Meyer WH

    更新日期：1994-01-01 00:00:00

  • Effects of trabecular bone on marrow relaxation in the tibia.

    abstract：:The effects of bone on marrow relaxation in the trabecular volume of the most proximal 3 cm in the left tibia were studied with a RF-spoiled gradient echo MRI protocol on a 1.0 T MR unit. The MR measurements were performed on six healthy volunteers, and repeated within one month in order to assess the precision of the...

    journal_title：Magnetic resonance imaging

    pub_type： 杂志文章

    doi：10.1016/s0730-725x(98)00159-3

    authors： Fransson A,Grampp S,Imhof H

    更新日期：1999-01-01 00:00:00

  • Prolonged T1 in patients with liver cirrhosis: an in vivo MRI study.

    abstract：:Fifteen patients with liver cirrhosis and two control groups were examined. The first control group consisted of 7 healthy volunteers, and the second group of 17 patients with nonfocal liver diseases. The T1 and T2 relaxation times were calculated from signal intensities read out from a region of interest centrally lo...

    journal_title：Magnetic resonance imaging

    pub_type： 杂志文章,评审

    doi：10.1016/0730-725x(90)90137-q

    authors： Thomsen C,Christoffersen P,Henriksen O,Juhl E

    更新日期：1990-01-01 00:00:00

  • Muscle and fat quantification in MRI gradient echo images using a partial volume detection method. Application to the characterization of pig belly tissue.

    abstract：:Complete dissection is the current reference method to quantify muscle and fat tissue on pig carcasses. Magnetic resonance imaging (MRI) is an appropriate nondestructive alternative method that can provide reliable and quantitative information on pig carcass composition without losing the spatial information. We have ...

    journal_title：Magnetic resonance imaging

    pub_type： 杂志文章

    doi：10.1016/j.mri.2005.05.001

    authors： Monziols M,Collewet G,Mariette F,Kouba M,Davenel A

    更新日期：2005-07-01 00:00:00

  • In vivo mapping of functional domains and axonal connectivity in cat visual cortex using magnetic resonance imaging.

    abstract：:Noninvasive cognitive neuroimaging studies based on functional magnetic resonance imaging (fMRI) are of ever-increasing importance for basic and clinical neurosciences. The explanatory power of fMRI could be greatly expanded, however, if the pattern of the neuronal circuitry underlying functional activation could be m...

    journal_title：Magnetic resonance imaging

    pub_type： 杂志文章

    doi：10.1016/j.mri.2003.08.014

    authors： Kim DS,Kim M,Ronen I,Formisano E,Kim KH,Ugurbil K,Mori S,Goebel R

    更新日期：2003-12-01 00:00:00

  • Noncontrast MRI with diffusion-weighted imaging as the sole imaging modality for detecting liver malignancy in patients with high risk for hepatocellular carcinoma.

    abstract：PURPOSE:To compare the diagnostic performance of the noncontrast MRI including DWI to the standard MRI for detecting hepatic malignancies in patients with chronic liver disease. MATERIALS AND METHODS:We included 135 patients with 136 histologically-confirmed hepatocellular carcinomas (HCCs), 12 cholangiocarcinomas, an...

    journal_title：Magnetic resonance imaging

    pub_type： 杂志文章

    doi：10.1016/j.mri.2013.12.021

    authors： Kim YK,Kim YK,Park HJ,Park MJ,Lee WJ,Choi D

    更新日期：2014-07-01 00:00:00

  • Fractional amplitude of low-frequency fluctuation changes in monkeys with spinal cord injury: a resting-state fMRI study.

    abstract：PURPOSE:Although functional magnetic resonance imaging (fMRI) has revealed that spinal cord injury (SCI) causes anomalous changes in task-induced brain activation, its effect during the resting state remains unclear. The aim of this study is to explore the changes of the brain resting-state function in non-human primat...

    journal_title：Magnetic resonance imaging

    pub_type： 杂志文章

    doi：10.1016/j.mri.2014.02.001

    authors： Rao JS,Ma M,Zhao C,Zhang AF,Yang ZY,Liu Z,Li XG

    更新日期：2014-06-01 00:00:00

  • Spectroscopic imaging of the brain with phased-array coils at 3.0 T.

    abstract：:The goal of this study was to develop and evaluate high-resolution magnetic resonance spectroscopic imaging (MRSI) utilizing the gains in signal-to-noise ratio (SNR) provided by combining higher magnetic field with high-sensitivity phased-array (PA) coils. We investigated the maximum improvement in spatial resolution ...

    journal_title：Magnetic resonance imaging

    pub_type： 杂志文章

    doi：10.1016/j.mri.2005.10.019

    authors： Xu D,Chen AP,Cunningham C,Osorio JA,Nelson SJ,Vigneron DB

    更新日期：2006-01-01 00:00:00

  • Fast magnetic resonance in vascular diseases of the abdomen.

    abstract：:Fast magnetic resonance (MR) imaging provides a consistent and predictable appearance of vascular abnormalities as shown by four patients with thrombi, dissection and aneurysm. Fast MR images are obtained during breath-holding, resulting in an absence of respiratory motion artifacts. The time of MR study is much less ...

    journal_title：Magnetic resonance imaging

    pub_type： 杂志文章

    doi：10.1016/0730-725x(88)90483-3

    authors： Raval B,Kulkarni M,Narayana P,Mehta S

    更新日期：1988-07-01 00:00:00

  • NMR imaging, NMR diffraction and applications of pulsed gradient spin echoes in porous media.

    abstract：:Diffraction ideas were first introduced to NMR by Mansfield and Grannell. Here we compare "Mansfield (k-space) diffraction" with the "diffusive (q-space) diffraction," noting their similarities and differences. The diffusive-diffraction concept is extremely helpful in elucidating the Pulsed Gradient Spin Echo NMR expe...

    journal_title：Magnetic resonance imaging

    pub_type： 杂志文章

    doi：10.1016/s0730-725x(96)00152-x

    authors： Callaghan PT

    更新日期：1996-01-01 00:00:00

  • Background parenchymal enhancement in the contralateral normal breast of patients undergoing neoadjuvant chemotherapy measured by DCE-MRI.

    abstract：:The purpose of this study was to analyze background parenchymal enhancement (BPE) in the contralateral normal breast of cancer patients during the course of neoadjuvant chemotherapy (NAC). Forty-five subjects were analyzed. Each patient had three MRIs, one baseline (B/L) and two follow-up (F/U) studies. The fibrogland...

    journal_title：Magnetic resonance imaging

    pub_type： 杂志文章

    doi：10.1016/j.mri.2013.07.014

    authors： Chen JH,Yu H,Lin M,Mehta RS,Su MY

    更新日期：2013-11-01 00:00:00

  • Non-enhanced magnetic resonance imaging of the small bowel at 7 Tesla in comparison to 1.5 Tesla: First steps towards clinical application.

    abstract：OBJECTIVE:To perform non-enhanced (NE) magnetic resonance imaging (MRI) of the small bowel at 7 Tesla (7T) and to compare it with 1.5 Tesla (1.5T). MATERIAL AND METHODS:Twelve healthy subjects were prospectively examined using a 1.5T and 7T MRI system. Coronal and axial true fast imaging with steady-state precession (...

    journal_title：Magnetic resonance imaging

    pub_type： 杂志文章

    doi：10.1016/j.mri.2015.11.012

    authors： Hahnemann ML,Kraff O,Maderwald S,Johst S,Orzada S,Umutlu L,Ladd ME,Quick HH,Lauenstein TC

    更新日期：2016-06-01 00:00:00

  • Effect of vasodilator hydralazine on tumor microvascular random flow and blood volume as measured by intravoxel incoherent motion (IVIM) weighted MRI in conjunction with Gd-DTPA-Albumin enhanced MRI.

    abstract：:We studied the effect of hydralazine on tumor blood volume fraction and microvascular random flow velocity magnitude by IVIM weighted MRI in conjunction with dynamic Gd-DTPA-Albumin enhanced MRI. Blood volume fraction maps were obtained from the dynamic Gd-DTPA-Albumin enhanced MRI measurements. The average blood volu...

    journal_title：Magnetic resonance imaging

    pub_type： 杂志文章

    doi：10.1016/s0730-725x(01)00431-3

    authors： Wang Z,Su MY,Najafi A,Nalcioglu O

    更新日期：2001-10-01 00:00:00

  • Is 'virtual histology' the next step after the 'virtual autopsy'? Magnetic resonance microscopy in forensic medicine.

    abstract：AIM:The study aimed to validate magnetic resonance microscopy (MRM) studies of forensic tissue specimens (skin samples with electric injury patterns) against the results from routine histology. METHODS AND RESULTS:Computed tomography and magnetic resonance imaging are fast becoming important tools in clinical and fore...

    journal_title：Magnetic resonance imaging

    pub_type： 杂志文章

    doi：10.1016/j.mri.2004.08.019

    authors： Thali MJ,Dirnhofer R,Becker R,Oliver W,Potter K

    更新日期：2004-10-01 00:00:00

  • Simultaneous recording of neuronal signals and functional NMR imaging.

    abstract：:We recently directly examined the relationship between blood-oxygen-level-dependent (BOLD) functional magnetic resonance imaging (fMRI) signals and neural activity by simultaneously acquiring electrophysiological and fMRI data from monkeys in a 4.7-T vertical scanner (Logothetis NK, Pauls J, Augath MA, Trinath T, Oelt...

    journal_title：Magnetic resonance imaging

    pub_type： 杂志文章

    doi：10.1016/j.mri.2007.03.015

    authors： Oeltermann A,Augath MA,Logothetis NK

    更新日期：2007-07-01 00:00:00

  • The diagnosis of hippocampal sclerosis: other techniques.

    abstract：:Pathologically, hippocampal sclerosis (HS) is characterized by neuronal loss and gliosis affecting particularly the pyramidal neurons of CA1, CA3, and CA4 with relative sparing of the CA2 neurons. This can be identified in vivo with magnetic resonance (MR) imaging techniques that can reveal both morphological and sign...

    journal_title：Magnetic resonance imaging

    pub_type： 杂志文章,评审

    doi：10.1016/0730-725x(95)02016-m

    authors： Jackson GD

    更新日期：1995-01-01 00:00:00

  • Dixon-based fat-free MR-angiography compared to first pass and steady-state high-resolution MR-angiography using a blood pool contrast agent.

    abstract：INTRODUCTION:Compared to standard arterial-only first-pass MR-angiography (FPMRA), imaging during the equilibrium phase of a blood pool contrast agent (steady state) has been shown to provide higher image quality and better stenosis grading. Homogenous Dixon fat-suppression promises to increase contrast by suppression ...

    journal_title：Magnetic resonance imaging

    pub_type： 杂志文章

    doi：10.1016/j.mri.2015.07.005

    authors： Homsi R,Gieseke J,Kukuk GM,Träber F,Willinek WA,Schild HH,Hadizadeh DR

    更新日期：2015-11-01 00:00:00

  • N-acetylaspartate reductions measured by 1H MRSI in cognitively impaired HIV-seropositive individuals.

    abstract：:We used magnetic resonance imaging (MRI) and water-suppressed proton MR spectroscopic imaging (1H MRSI) to study the effects of human immunodeficiency virus (HIV) infection on the brain. Our recent in vivo finding of lower N-acetylaspartate (NAA), a putative marker of neurons, in the supraventricular brain of cognitiv...

    journal_title：Magnetic resonance imaging

    pub_type： 杂志文章

    doi：10.1016/0730-725x(94)92460-0

    authors： Meyerhoff DJ,MacKay S,Poole N,Dillon WP,Weiner MW,Fein G

    更新日期：1994-01-01 00:00:00

  • Automated measurement of fat infiltration in the hip abductors from Dixon magnetic resonance imaging.

    abstract：PURPOSE:Intramuscular fat infiltration is a dynamic process, in response to exercise and muscle health, which can be quantified by estimating fat fraction (FF) from Dixon MRI. Healthy hip abductor muscles are a good indicator of a healthy hip and an active lifestyle as they have a fundamental role in walking. The autom...

    journal_title：Magnetic resonance imaging

    pub_type： 杂志文章

    doi：10.1016/j.mri.2020.06.019

    authors： Belzunce MA,Henckel J,Fotiadou A,Di Laura A,Hart A

    更新日期：2020-10-01 00:00:00

  • Surface magnetic relaxation in cement pastes.

    abstract：:Surface magnetic relaxation in porous media is usually attributed to hindered rotation or to paramagnetic impurities on the surface. In cement pastes, however, it seems reasonable to attribute surface relaxation to dipole interactions in water adsorbed as water of hydration on grain surfaces. The rate limiting factor ...

    journal_title：Magnetic resonance imaging

    pub_type： 杂志文章

    doi：10.1016/0730-725x(94)91517-2

    authors： Mendelson KS,Halperin WP,Jehng JY,Song YQ

    更新日期：1994-01-01 00:00:00

  • Tsallis-Entropy Segmentation through MRF and Alzheimer anatomic reference for Brain Magnetic Resonance Parcellation.

    abstract：:Quantifying the intracranial tissue volume changes in magnetic resonance imaging (MRI) assists specialists to analyze the effects of natural or pathological changes. Since these changes can be subtle, the accuracy of the automatic compartmentalization method is always criticized by specialists. We propose and then eva...

    journal_title：Magnetic resonance imaging

    pub_type： 杂志文章

    doi：10.1016/j.mri.2019.11.002

    authors： Azimbagirad M,Simozo FH,Senra Filho ACS,Murta Junior LO

    更新日期：2020-01-01 00:00:00

  • Measurement of fat fraction in the human thymus by localized NMR and three-point Dixon MRI techniques.

    abstract：PURPOSE:To develop a protocol to non-invasively measure and map fat fraction, fat/(fat+water), as a function of age in the adult thymus for future studies monitoring the effects of interventions aimed at promoting thymic rejuvenation and preservation of immunity in older adults. MATERIALS AND METHODS:Three-dimensional...

    journal_title：Magnetic resonance imaging

    pub_type： 杂志文章

    doi：10.1016/j.mri.2018.03.016

    authors： Fishbein KW,Makrogiannis SK,Lukas VA,Okine M,Ramachandran R,Ferrucci L,Egan JM,Chia CW,Spencer RG

    更新日期：2018-07-01 00:00:00

  • Evaluation of stacked resonators to enhance the performance of a surface receive-only array for prostate MRI at 3 Tesla.

    abstract：:Prostate MRI is an important tool to diagnose and characterize cancer. High local sensitivity and good parallel imaging performance are of paramount importance for diagnostic quality and efficiency. The purpose of this work was to evaluate stacked resonators as part of a surface receiver array for prostate MRI at 3 Te...

    journal_title：Magnetic resonance imaging

    pub_type： 杂志文章

    doi：10.1016/j.mri.2018.07.010

    authors： Chacon-Caldera J,Fischer A,Malzacher M,Vetter Y,Davids M,Flöser M,Stumpf C,Schad LR

    更新日期：2018-11-01 00:00:00

  • T1 and T2* mapping of the human quadriceps and patellar tendons using ultra-short echo-time (UTE) imaging and bivariate relaxation parameter-based volumetric visualization.

    abstract：:Quantification of magnetic resonance (MR)-based relaxation parameters of tendons and ligaments is challenging due to their very short transverse relaxation times, requiring application of ultra-short echo-time (UTE) imaging sequences. We quantify both T1 and T2* in the quadriceps and patellar tendons of healthy volunt...

    journal_title：Magnetic resonance imaging

    pub_type： 杂志文章

    doi：10.1016/j.mri.2019.07.015

    authors： Krämer M,Maggioni MB,Brisson NM,Zachow S,Teichgräber U,Duda GN,Reichenbach JR

    更新日期：2019-11-01 00:00:00

  • High-field magnetic resonance imaging using solenoid radiofrequency coils.

    abstract：:High-resolution magnetic resonance imaging using dedicated high-field radiofrequency micro-coils at 16.4 T (700 MHz) was investigated. Specific solenoid coils primarily using silver and copper as conductors with enamel and polyurethane coatings were built to establish which coil configuration produces the best image. ...

    journal_title：Magnetic resonance imaging

    pub_type： 杂志文章

    doi：10.1016/j.mri.2012.04.027

    authors： Vegh V,Gläser P,Maillet D,Cowin GJ,Reutens DC

    更新日期：2012-10-01 00:00:00

  • Increased confidence of diagnosis of Ewing sarcoma using T2-weighted MR images.

    abstract：:To assess whether magnetic resonance imaging could assist in diagnosing Ewing sarcoma, we retrospectively analyzed T1- and T2-weighted images of 24 consecutive solitary lytic bone lesions, including 18 cases of histologically proven Ewing sarcoma, and six aggressive-appearing benign lesions including eosinophilic gran...

    journal_title：Magnetic resonance imaging

    pub_type： 杂志文章

    doi：10.1016/0730-725x(94)92450-3

    authors： Hanna SL,Fletcher BD,Kaste SC,Fairclough DL,Parham DM

    更新日期：1994-01-01 00:00:00

  • Localized high-resolution DTI of the human midbrain using single-shot EPI, parallel imaging, and outer-volume suppression at 7T.

    abstract：:Localized high-resolution diffusion tensor images (DTI) from the midbrain were obtained using reduced field-of-view (rFOV) methods combined with SENSE parallel imaging and single-shot echo planar (EPI) acquisitions at 7T. This combination aimed to diminish sensitivities of DTI to motion, susceptibility variations, and...

    journal_title：Magnetic resonance imaging

    pub_type： 杂志文章

    doi：10.1016/j.mri.2013.01.013

    authors： Wargo CJ,Gore JC

    更新日期：2013-07-01 00:00:00

  • Applications of controlled-flow laser-polarized xenon gas to porous and granular media study.

    abstract：:We report initial NMR studies of continuous flow laser-polarized xenon gas, both in unrestricted tubing, and in a model porous media. The study uses Pulsed Gradient Spin Echo-based techniques in the gas-phase, with the aim of obtaining more sophisticated information than just translational self-diffusion coefficients....

    journal_title：Magnetic resonance imaging

    pub_type： 杂志文章

    doi：10.1016/s0730-725x(03)00156-5

    authors： Mair RW,Wang R,Rosen MS,Candela D,Cory DG,Walsworth RL

    更新日期：2003-04-01 00:00:00

  • Assessment of the anomalous pulmonary circulation by dynamic contrast-enhanced MR angiography in under four seconds.

    abstract：:The purpose of this study was to demonstrate the initial results of the dynamic contrast-enhanced MRA in under four seconds in the assessment of anomalous pulmonary circulation. We performed dynamic contrast enhanced MRA on ten patients with a temporal resolution of 2-3 sec for each phase. Five patients had pulmonary ...

    journal_title：Magnetic resonance imaging

    pub_type： 杂志文章

    doi：10.1016/s0730-725x(02)00634-3

    authors： Balci NC,Yalçin Y,Tunaci A,Balci Y

    更新日期：2003-01-01 00:00:00