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Measurement of fat fraction in the human thymus by localized NMR and three-point Dixon MRI techniques.

Abstract：

PURPOSE:To develop a protocol to non-invasively measure and map fat fraction, fat/(fat+water), as a function of age in the adult thymus for future studies monitoring the effects of interventions aimed at promoting thymic rejuvenation and preservation of immunity in older adults. MATERIALS AND METHODS:Three-dimensional spoiled gradient echo 3T MRI with 3-point Dixon fat-water separation was performed at full inspiration for thymus conspicuity in 36 volunteers 19 to 56 years old. Reproducible breath-holding was facilitated by real-time pressure recording external to the console. The MRI method was validated against localized spectroscopy in vivo, with ECG triggering to compensate for stretching during the cardiac cycle. Fat fractions were corrected for T1 and T2 bias using relaxation times measured using inversion recovery-prepared PRESS with incremented echo time. RESULTS:In thymus at 3 T, T1water = 978 ± 75 ms, T1fat = 323 ± 37 ms, T2water = 43.4 ± 9.7 ms and T2fat = 52.1 ± 7.6 ms were measured. Mean T1-corrected MRI fat fractions varied from 0.2 to 0.8 and were positively correlated with age, weight and body mass index (BMI). In subjects with matching MRI and MRS fat fraction measurements, the difference between these measurements exhibited a mean of -0.008 with a 95% confidence interval of (0.123, -0.138). CONCLUSIONS:3-point Dixon MRI of the thymus with T1 bias correction produces quantitative fat fraction maps that correlate with T2-corrected MRS measurements and show age trends consistent with thymic involution.

journal_name

Magn Reson Imaging

journal_title

Magnetic resonance imaging

authors

Fishbein KW,Makrogiannis SK,Lukas VA,Okine M,Ramachandran R,Ferrucci L,Egan JM,Chia CW,Spencer RG

doi

10.1016/j.mri.2018.03.016

subject

Has Abstract

pub_date

2018-07-01 00:00:00

pages

110-118

eissn

0730-725X

issn

1873-5894

pii

S0730-725X(18)30047-X

journal_volume

50

pub_type

杂志文章

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