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Oxygen-sensitive 19F NMR imaging of the vascular system in vivo.

Abstract：

:The fluorine nuclear magnetic resonance spin-lattice relaxation rate (1/T1) of the perfluorochemical blood substitute perfluorotripropylamine (FTPA) is very sensitive to oxygen tension. This presents the possibility of measuring blood oxygen tension by 19F MR imaging. We obtained oxygen-sensitive 19F NMR images of the circulatory system of rats infused with emulsified FTPA. Blood oxygenation was assessed under conditions of both air- and 100% O2-breathing. T1 relaxation times were derived from MR images using a partial saturation pulse sequence. The T1 times were compared with a phantom calibration curve to calculate average blood pO2 values in the lung, liver, and spleen. The results showed marked, organ-specific increases in blood oxygen tension when the rat breathed 100% O2 instead of air.

journal_name

Magn Reson Imaging

journal_title

Magnetic resonance imaging

authors

Fishman JE,Joseph PM,Floyd TF,Mukherji B,Sloviter HA

doi

10.1016/0730-725x(87)90005-1

subject

Has Abstract

pub_date

1987-01-01 00:00:00

pages

279-85

issue

4

eissn

0730-725X

issn

1873-5894

pii

0730-725X(87)90005-1

journal_volume

5

pub_type

杂志文章

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