Effect of anesthesia on the signal intensity in tumors using BOLD-MRI: comparison with flow measurements by Laser Doppler flowmetry and oxygen measurements by luminescence-based probes.


:BOLD-contrast functional magnetic resonance imaging (MRI) was used to assess the evolution of tumor oxygenation and blood flow after administration of four different anesthetics: pentobarbital (60 mg/kg), ketamine/xylazine (80/8 mg/kg), fentanyl/droperidol (0.078/3.9 mg/kg), and isoflurane (1.5%). Gradient echo sequences were carried out at 4.7 Tesla in a TLT tumor model implanted in the muscle of NMRI mice. In parallel experiments, tumor blood flow and tumor pO2 were measured using the OxyLite/OxyFlo probe system. A comparison was made with the changes occurring in the skeletal muscle (host tissue). The signal intensity was dramatically decreased in tumors after administration of anesthetics, except isoflurane. These results correlated well with measurements of oxygenation and blood perfusion. Isoflurane produced constant muscle pO2 and blood perfusion although large transient fluctuations in pO2 and blood flow were reported in some tumors. Our results emphasize the need for careful monitoring of the effects of anesthesia when trying to identify new therapeutic approaches that are aimed at modulating tumor hemodynamics.


Magn Reson Imaging


Baudelet C,Gallez B




Has Abstract


2004-09-01 00:00:00














  • Measurements of RF heating during 3.0-T MRI of a pig implanted with deep brain stimulator.

    abstract:PURPOSE:To present preliminary, in vivo temperature measurements during MRI of a pig implanted with a deep brain stimulation (DBS) system. MATERIALS AND METHODS:DBS system (Medtronic Inc., Minneapolis, MN) was implanted in the brain of an anesthetized pig. 3.0-T MRI was performed with a T/R head coil using the low-SAR...

    journal_title:Magnetic resonance imaging

    pub_type: 杂志文章


    authors: Gorny KR,Presti MF,Goerss SJ,Hwang SC,Jang DP,Kim I,Min HK,Shu Y,Favazza CP,Lee KH,Bernstein MA

    更新日期:2013-06-01 00:00:00

  • Fat ViP MRI: Virtual Phantom Magnetic Resonance Imaging of water-fat systems.

    abstract:OBJECT:Virtual Phantom Magnetic Resonance Imaging (ViP MRI) is a method to generate reference signals on MR images, using external radiofrequency (RF) signals. The aim of this study was to assess the feasibility of ViP MRI to generate complex-data images of phantoms mimicking water-fat systems. MATERIALS AND METHODS:V...

    journal_title:Magnetic resonance imaging

    pub_type: 杂志文章


    authors: Salvati R,Hitti E,Bellanger JJ,Saint-Jalmes H,Gambarota G

    更新日期:2016-06-01 00:00:00

  • Reproducibility of MRI-derived measurements of right ventricular volumes and myocardial mass.

    abstract::Magnetic resonance (MR) imaging has been shown to provide accurate measurements of right ventricular (RV) volumes and myocardial mass. The purpose of this study was to evaluate the reproducibility of MR imaging, which in clinical practice may be as important as its absolute accuracy. The reproducibility of MR imaging ...

    journal_title:Magnetic resonance imaging

    pub_type: 杂志文章


    authors: Pattynama PM,Lamb HJ,Van der Velde EA,Van der Geest RJ,Van der Wall EE,De Roos A

    更新日期:1995-01-01 00:00:00

  • Spectral pattern of total creatine and trimethyl ammonium in multiple sclerosis.

    abstract::Fatigue and impairment mobility are frequent problems in multiple sclerosis (MS). Despite its enormous potential, in vivo (1)H MRS of skeletal muscles for MS patients is a largely unexplored field. One fundamental question remains unanswered: whether MS can cause observable proton metabolite changes. High quality two-...

    journal_title:Magnetic resonance imaging

    pub_type: 杂志文章


    authors: Hu J,Xu Y,Jiang Q,Sehgal V,Shen Y,Xuan Y,Xia Y

    更新日期:2004-04-01 00:00:00

  • A robust electrical conductivity imaging method with total variation and wavelet regularization.

    abstract:PURPOSE:This study aims to develop and evaluate a robust conductivity imaging method that combines total variation and wavelet regularization to enhance the accuracy of conductivity maps. THEORY AND METHODS:The proposed approach is based on a gradient-based method. The central equation is derived from Maxwell's equati...

    journal_title:Magnetic resonance imaging

    pub_type: 杂志文章


    authors: Sun X,Lu L,Qi L,Mei Y,Liu X,Chen W

    更新日期:2020-06-01 00:00:00

  • Magic angle effect in magnetic resonance imaging of the Achilles tendon and enthesis.

    abstract::Collagen fibers in tendons and entheses are highly ordered. The protons within the bound water are subject to dipolar interactions whose strength depends on the orientation of the fibers to the static magnetic field B(0). Clinical pulse sequences have been employed to investigate this magic angle effect of the Achille...

    journal_title:Magnetic resonance imaging

    pub_type: 杂志文章


    authors: Du J,Pak BC,Znamirowski R,Statum S,Takahashi A,Chung CB,Bydder GM

    更新日期:2009-05-01 00:00:00

  • Effect of off-frequency sampling in magnetic resonance elastography.

    abstract::In magnetic resonance elastography (MRE), shear waves at a certain frequency are encoded through bipolar gradients that switch polarity at a controlled encoding frequency and are offset in time to capture wave propagation using a controlled sampling frequency. In brain MRE, there is a possibility that the mechanical a...

    journal_title:Magnetic resonance imaging

    pub_type: 杂志文章


    authors: Johnson CL,Chen DD,Olivero WC,Sutton BP,Georgiadis JG

    更新日期:2012-02-01 00:00:00

  • Pharmacokinetic analysis of glioma compartments with dynamic Gd-DTPA-enhanced magnetic resonance imaging.

    abstract::Dynamic contrast-enhanced magnetic resonance imaging (MRI) is widely used for measuring perfusion and blood volume, especially cerebral blood volume (CBV). In case of blood-brain barrier (BBB) disruption, the conventional techniques only partially determine the pharmacokinetic parameters of contrast medium (CM) exchan...

    journal_title:Magnetic resonance imaging

    pub_type: 杂志文章


    authors: Lüdemann L,Hamm B,Zimmer C

    更新日期:2000-12-01 00:00:00

  • Diffusion and spatially resolved NMR in Berea and Venezuelan oil reservoir rocks.

    abstract::Conventional and spatially resolved proton NMR and relaxation measurements are used in order to study the molecular motions and the equilibrium and nonequilibrium diffusion of oils in Berea sandstone and Venezuelan reservoir rocks. In the water-saturated Berea a single line with T*2 congruent to 150 microseconds is ob...

    journal_title:Magnetic resonance imaging

    pub_type: 杂志文章


    authors: Murgich J,Corti M,Pavesi L,Voltini F

    更新日期:1992-01-01 00:00:00

  • Evaluation of pancreatic exocrine insufficiency by cine-dynamic MRCP using spatially selective inversion-recovery (IR) pulse: Correlation with severity of chronic pancreatitis based on morphological changes of pancreatic duct.

    abstract:PURPOSE:To evaluate the correlation between the pancreatic exocrine insufficiency estimated by cine-dynamic MRCP using spatially selective IR pulse and the severity stages (modified Cambridge classification) based on morphological changes of the pancreatic duct in patients with suspected chronic pancreatitis. MATERIAL...

    journal_title:Magnetic resonance imaging

    pub_type: 杂志文章


    authors: Yasokawa K,Ito K,Kanki A,Yamamoto A,Torigoe T,Sato T,Tamada T

    更新日期:2018-05-01 00:00:00

  • Three-dimensional magnetic resonance imaging after ultrasonography for assessment of fetal gastroschisis.

    abstract::A 24-year-old woman (Gravida I, Para I) at estimated 32 weeks of pregnancy was referred to our department for evaluation of a suspected fetal gastroschisis. Ultrasound scan revealed multiple loops of dilated bowel outside the fetal abdomen and absence of membrane surrounding the herniated loops of the intestines. Thre...

    journal_title:Magnetic resonance imaging

    pub_type: 杂志文章


    authors: Sasaki Y,Miyamoto T,Hidaka Y,Satoh H,Takuma N,Sengoku K,Sugimori H,Inaoka T,Aburano T

    更新日期:2006-02-01 00:00:00

  • A 32-channel coil system for MR vessel wall imaging of intracranial and extracranial arteries at 3T.

    abstract:PURPOSE:To develop a RF coil system for joint imaging of intracranial and extracranial arterial vessel wall at 3T. MATERIALS AND METHOD:The coil system consists of a 24-channel head coil combined with an 8-channel carotid coil. It is compared with a standard coil configuration (12-channel head coil+4-channel neck coil...

    journal_title:Magnetic resonance imaging

    pub_type: 杂志文章


    authors: Hu X,Li Y,Zhang L,Zhang X,Liu X,Chung YC

    更新日期:2017-02-01 00:00:00

  • A broad line NMR and MRI study of water and water transport in Portland cement pastes.

    abstract::The results of a magnetic resonance spin-spin relaxation analysis and broad-line magnetic resonance imaging (MRI) (gradient-echo and stray-field imaging) study of water and water transport in Portland cement pastes are presented. The effect of varying the cure conditions and the water to cement (w/c) ratio of the samp...

    journal_title:Magnetic resonance imaging

    pub_type: 杂志文章


    authors: Bohris AJ,Goerke U,McDonald PJ,Mulheron M,Newling B,Le Page B

    更新日期:1998-06-01 00:00:00

  • Echo-shifted multislice EPI for high-speed fMRI.

    abstract::The advantages of event-related functional Magnetic Resonance Imaging (fMRI) and the increasing use of fMRI in cognitive experiments are both driving the development of techniques that allow images sensitive to the blood oxygen level-dependent effect to be acquired at ever-higher temporal resolution. Here, we present ...

    journal_title:Magnetic resonance imaging

    pub_type: 杂志文章


    authors: Gibson A,Peters AM,Bowtell R

    更新日期:2006-05-01 00:00:00

  • Three dimensional k-space trajectory design using genetic algorithms.

    abstract::Image quality and total scan time in MRI are determined in large part by the trajectory employed to sample the Fourier space. Each trajectory has different properties like coverage of k-space, scan time, sensitivity to off-resonance conditions, etc. These properties are often contradictory, therefore a universal optim...

    journal_title:Magnetic resonance imaging

    pub_type: 杂志文章


    authors: Sabat S,Mir R,Guarini M,Guesalaga A,Irarrazaval P

    更新日期:2003-09-01 00:00:00

  • Non-contrast enhanced 3D SSFP MRA of the renal allograft vasculature: a comparison between radial linear combination and Cartesian inflow-weighted acquisitions.

    abstract::Renal transplant patients often require imaging to ensure appropriate graft placement, to assess integrity of transplant vessel anastomosis and to evaluate for stenosis that can be a cause of graft failure. Because there is risk for nephrogenic systemic fibrosis in the setting of renal insufficiency, the use of non-co...

    journal_title:Magnetic resonance imaging

    pub_type: 杂志文章


    authors: Bultman EM,Klaers J,Johnson KM,François CJ,Schiebler ML,Reeder SB,Block WF

    更新日期:2014-02-01 00:00:00

  • Evaluation of intracranial stenoses and aneurysms with accelerated 4D flow.

    abstract::The aim of this study was to evaluate intracranial arterial stenoses and aneurysms with accelerated time-resolved three-dimensional (3D) phase-contrast MRI or 4D flow. The 4D flow technique was utilized to image four normal volunteers, two patients with intracranial stenoses and two patients with intracranial aneurysm...

    journal_title:Magnetic resonance imaging

    pub_type: 杂志文章


    authors: Hope TA,Hope MD,Purcell DD,von Morze C,Vigneron DB,Alley MT,Dillon WP

    更新日期:2010-01-01 00:00:00

  • Analysis of kinetic curve and model-based perfusion parameters on dynamic contrast enhanced MRI in breast cancer patients: Correlations with dominant stroma type.

    abstract:OBJECTIVE:Our purpose was to evaluate imaging findings of breast cancers according to the dominant stroma type by using kinetic curve analysis and model-based perfusion parameters from dynamic contrast-enhanced magnetic resonance imaging. METHODS:From March 2011 to September 2011, 64 cancers in 64 patients were includ...

    journal_title:Magnetic resonance imaging

    pub_type: 杂志文章


    authors: Yim H,Kang DK,Jung YS,Jeon GS,Kim TH

    更新日期:2016-01-01 00:00:00

  • Quantifying and comparing region-of-interest activation patterns in functional brain MR imaging: methodology considerations.

    abstract::The general aims of functional brain magnetic resonance imaging (fMRI) studies are to ascertain which areas of the brain are activated during a specific task, the extent of this activation, whether different groups of subjects demonstrate different patterns of activation, and how these groups behave in different tasks...

    journal_title:Magnetic resonance imaging

    pub_type: 杂志文章


    authors: Constable RT,Skudlarski P,Mencl E,Pugh KR,Fulbright RK,Lacadie C,Shaywitz SE,Shaywitz BA

    更新日期:1998-04-01 00:00:00

  • Dual-echo breathhold T(2)-weighted fast spin echo MR imaging of liver lesions.

    abstract::The purpose of this study was to develop a multi-shot dual-echo breathhold fast spin echo technique (DFSE) and compare it with conventional spin echo (T2SE) for T(2)-weighted MR imaging of liver lesions. The DFSE acquisition (EffTE1/EffTE2/TR = 66/143/2100 ms) imaged 5 sections per 17 s breathhold. T2SE imaging (TE1/T...

    journal_title:Magnetic resonance imaging

    pub_type: 杂志文章


    authors: Rydberg JN,Tervonen OA,Rydberg DB,Lomas DJ,Ehman RL,Riederer SJ

    更新日期:2000-02-01 00:00:00

  • Dependence of temporal diffusion spectra on microstructural properties of biological tissues.

    abstract::The apparent diffusion coefficient (ADC) measured using magnetic resonance imaging methods provides information on microstructural properties of biological tissues, and thus has found applications as a useful biomarker for assessing changes such as those that occur in ischemic stroke and cancer. Conventional pulsed gr...

    journal_title:Magnetic resonance imaging

    pub_type: 杂志文章


    authors: Xu J,Does MD,Gore JC

    更新日期:2011-04-01 00:00:00

  • Increasing mean airway pressure reduces functional MRI (fMRI) signal in the primary visual cortex.

    abstract::Changes in both blood flow and blood oxygenation determine the functional MRI (fMRI) signal. In the present study factors responsible for blood oxygenation (e.g., FiO(2)) were held constant so that changes in pixel count would above all reflect changes in regional cerebral blood flow (rCBF). Continuous positive airway...

    journal_title:Magnetic resonance imaging

    pub_type: 杂志文章


    authors: Lorenz IH,Kolbitsch C,Hörmann C,Schocke M,Kremser C,Zschiegner F,Felber S,Benzer A

    更新日期:2001-01-01 00:00:00

  • High resolution simultaneous imaging of intracranial and extracranial arterial wall with improved cerebrospinal fluid suppression.

    abstract:PURPOSE:To develop a technique for three dimensional (3D) high resolution joint imaging of intracranial and extracranial arterial walls with improved cerebrospinal fluid (CSF) suppression and good blood suppression based on T1 weighted sampling perfection with application optimized contrast using different angle evolut...

    journal_title:Magnetic resonance imaging

    pub_type: 杂志文章


    authors: Zhang L,Zhang N,Wu J,Liu X,Chung YC

    更新日期:2017-12-01 00:00:00

  • Quantitation of non-Einstein diffusion behavior of water in biological tissues by proton MR diffusion imaging: synthetic image calculations.

    abstract::The non-Einstein diffusion behavior of water in a model biological tissue system, intact duck embryos, has been investigated by the use of an in vivo proton pulsed-gradient spin-echo (PGSE) MR imaging technique. Multiple-frame MR images of the intact duck embryos and control solution (0.5 mM CuSO4 doped water) were ac...

    journal_title:Magnetic resonance imaging

    pub_type: 杂志文章


    authors: Cheng KH

    更新日期:1993-01-01 00:00:00

  • Voxelwise analysis of diffusion MRI of cervical spinal cord using tract-based spatial statistics.

    abstract::Robust voxelwise analysis using tract-based spatial statistics (TBSS) together with permutation statistical method is standardly used in analyzing diffusion tensor imaging (DTI) of brain. A similar analytical method could be useful when studying DTI of cervical spinal cord. Based on anatomical data of sixty-four healt...

    journal_title:Magnetic resonance imaging

    pub_type: 杂志文章


    authors: Dostál M,Keřkovský M,Staffa E,Bednařík J,Šprláková-Puková A,Mechl M

    更新日期:2020-11-01 00:00:00

  • Summary of special issue on gadolinium bioeffects and toxicity with a look to the future.

    abstract::This summary attempts to provide forward-looking concepts regarding gadolinium related toxicity, as discussed in further detail in this issue. ...

    journal_title:Magnetic resonance imaging

    pub_type: 杂志文章,评审


    authors: Semelka RC,Ramalho M,Jay M

    更新日期:2016-12-01 00:00:00

  • Assessment of iron oxide particles (AMI 227) and a gadolinium complex (Gd-DOTA) in dynamic susceptibility contrast MR imagings (FLASH and EPI) in a tumor model implanted in rats.

    abstract::The objective of our study was to assess the feasibility of dynamic susceptibility contrast MR technique after bolus injection of SPIO and Gd-DOTA in a tumor model implanted in rats. Tumors were subcutaneously implanted in 24 rats. A FLASH sequence and EPI were evaluated. Different doses of AMI 227 and Gd-DOTA were as...

    journal_title:Magnetic resonance imaging

    pub_type: 杂志文章


    authors: Loubeyre P,De Jaegere T,Miao Y,Landuyt W,Marchal G

    更新日期:1999-05-01 00:00:00

  • Simple phase method for measurement of magnetic field gradient waveforms.

    abstract::Magnetic field gradients play a fundamental role in MR imaging and localized spectroscopy. The MRI experiment, in particular fast MRI, relies on precise gradient switching, which has become more demanding with the constantly growing number of fast imaging techniques. Here we present a simple MR method to measure the b...

    journal_title:Magnetic resonance imaging

    pub_type: 杂志文章


    authors: Latta P,Gruwel ML,Volotovskyy V,Weber MH,Tomanek B

    更新日期:2007-11-01 00:00:00

  • Phase contrast and time-of-flight magnetic resonance angiography of the intracerebral arteries at 1.5, 3 and 7 T.

    abstract:PURPOSE:Time-of-flight (ToF) and phase contrast (PC) magnetic resonance angiographies (MRAs) are noninvasive applications to depict the cerebral arteries. Both approaches can image the cerebral vasculature without the administration of intravenous contrast. Therefore, it is used in routine clinical evaluation of cerebr...

    journal_title:Magnetic resonance imaging

    pub_type: 杂志文章


    authors: Stamm AC,Wright CL,Knopp MV,Schmalbrock P,Heverhagen JT

    更新日期:2013-05-01 00:00:00

  • Contrast-enhanced 3D MR voiding urethrography: preliminary results.

    abstract::Contrast-enhanced 3D MR voiding urethrography (CE 3D MRVU) was performed on 5 healthy volunteers and 18 patients with urethral disease. After intravenous injection of 0.3 ml/kg gadolinium, the images of the three consecutive acquisitions of the 3D MRVU technique were obtained during voiding. The raw data were reconstr...

    journal_title:Magnetic resonance imaging

    pub_type: 临床试验,杂志文章


    authors: Yekeler E,Suleyman E,Tunaci A,Tunaci M,Balci NC,Onem K,Tunc M,Acunas G

    更新日期:2004-11-01 00:00:00