Assessment of iron oxide particles (AMI 227) and a gadolinium complex (Gd-DOTA) in dynamic susceptibility contrast MR imagings (FLASH and EPI) in a tumor model implanted in rats.

Abstract:

:The objective of our study was to assess the feasibility of dynamic susceptibility contrast MR technique after bolus injection of SPIO and Gd-DOTA in a tumor model implanted in rats. Tumors were subcutaneously implanted in 24 rats. A FLASH sequence and EPI were evaluated. Different doses of AMI 227 and Gd-DOTA were assessed. Mean signal intensity vs. time curves were plotted. Well-shaped curves of the first pass of the contrast agent were only obtained with Gd-DOTA. According to these results it appears difficult to assess tumor blood volume with USPIO dynamic susceptibility contrast imaging.

journal_name

Magn Reson Imaging

authors

Loubeyre P,De Jaegere T,Miao Y,Landuyt W,Marchal G

doi

10.1016/s0730-725x(98)00197-0

subject

Has Abstract

pub_date

1999-05-01 00:00:00

pages

627-31

issue

4

eissn

0730-725X

issn

1873-5894

pii

S0730725X98001970

journal_volume

17

pub_type

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