Abstract：
:Increasing scientific interest in the zebrafish as a model organism across a range of biomedical and biological research areas raises the need for the development of in vivo imaging tools appropriate to this subject. Development of the embryonic and early stage forms of the subject can currently be assessed using optical based techniques due to the transparent nature of the species at these early stages. However this is not an option during the juvenile and adult stages when the subjects become opaque. Magnetic resonance imaging (MRI) techniques would allow for the longitudinal and non-invasive assessment of development and health in these later life stages. However, the small size of the zebrafish and its aquatic environment represent considerable challenges for the technique. We have developed a suitable flow cell system that incorporates a dedicated MRI imaging coil to solve these challenges. The system maintains and monitors a zebrafish during a scan and allows for it to be fully recovered. The imaging properties of this system compare well with those of other preclinical MRI coils used in rodent models. This enables the rapid acquisition of MRI data which are comparable in terms of quality and acquisition time. This would allow the many unique opportunities of the zebrafish as a model organism to be combined with the benefits of non-invasive MRI.
journal_name
Magn Reson Imagingjournal_title
Magnetic resonance imagingauthors
Merrifield GD,Mullin J,Gallagher L,Tucker C,Jansen MA,Denvir M,Holmes WMdoi
10.1016/j.mri.2016.10.013subject
Has Abstractpub_date
2017-04-01 00:00:00pages
9-15eissn
0730-725Xissn
1873-5894pii
S0730-725X(16)30160-6journal_volume
37pub_type
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journal_title：Magnetic resonance imaging
pub_type： 杂志文章
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journal_title：Magnetic resonance imaging
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更新日期：2020-02-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/0730-725x(93)90069-p
更新日期：1993-01-01 00:00:00
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journal_title：Magnetic resonance imaging
pub_type： 杂志文章
doi：10.1016/0730-725x(92)90411-r
更新日期：1992-01-01 00:00:00
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journal_title：Magnetic resonance imaging
pub_type： 杂志文章
doi：10.1016/j.mri.2015.10.025
更新日期：2016-02-01 00:00:00
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journal_title：Magnetic resonance imaging
pub_type： 杂志文章
doi：10.1016/0730-725x(94)92198-9
更新日期：1994-01-01 00:00:00
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journal_title：Magnetic resonance imaging
pub_type： 杂志文章
doi：10.1016/j.mri.2013.07.009
更新日期：2014-01-01 00:00:00
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journal_title：Magnetic resonance imaging
pub_type： 杂志文章
doi：10.1016/j.mri.2018.10.009
更新日期：2019-02-01 00:00:00
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journal_title：Magnetic resonance imaging
pub_type： 杂志文章
doi：10.1016/0730-725x(84)90065-1
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journal_title：Magnetic resonance imaging
pub_type： 杂志文章
doi：10.1016/0730-725x(94)91234-n
更新日期：1994-01-01 00:00:00
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journal_title：Magnetic resonance imaging
pub_type： 杂志文章
doi：10.1016/j.mri.2005.01.002
更新日期：2005-02-01 00:00:00
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journal_title：Magnetic resonance imaging
pub_type： 杂志文章
doi：10.1016/j.mri.2014.12.010
更新日期：2015-05-01 00:00:00
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doi：10.1016/s0730-725x(02)00478-2
更新日期：2002-01-01 00:00:00
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doi：10.1016/s0730-725x(98)00197-0
更新日期：1999-05-01 00:00:00
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journal_title：Magnetic resonance imaging
pub_type： 杂志文章
doi：10.1016/j.mri.2018.09.010
更新日期：2019-02-01 00:00:00
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journal_title：Magnetic resonance imaging
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doi：10.1016/j.mri.2010.10.002
更新日期：2011-04-01 00:00:00
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journal_title：Magnetic resonance imaging
pub_type： 杂志文章
doi：10.1016/0730-725x(90)90009-q
更新日期：1990-01-01 00:00:00
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doi：10.1016/j.mri.2014.08.041
更新日期：2015-02-01 00:00:00
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journal_title：Magnetic resonance imaging
pub_type： 杂志文章
doi：10.1016/j.mri.2019.03.004
更新日期：2019-06-01 00:00:00
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journal_title：Magnetic resonance imaging
pub_type： 杂志文章
doi：10.1016/0730-725x(93)90035-c
更新日期：1993-01-01 00:00:00
abstract：:The purpose of this study was to evaluate the value of Ferumoxide-enhanced magnetic resonance (MR) imaging in the detection of hepatic metastases in high-risk patients treated for colorectal cancer that have rising CEA. We used 19 patients treated previously for colorectal cancer with rising CEA levels underwent an un...
journal_title：Magnetic resonance imaging
pub_type： 临床试验,杂志文章
doi：10.1016/s0730-725x(99)00134-4
更新日期：2000-04-01 00:00:00
