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Quantifications of in vivo labeled stem cells based on measurements of magnetic moments.

Abstract：

:Cells labeled by super paramagnetic iron-oxide (SPIO) nanoparticles are more easily seen in gradient echo MR images, but it has not been shown that the amount of nanoparticles or the number of cells can be directly quantified from MR images. This work utilizes a previously developed and improved Complex Image Summation around a Spherical or Cylindrical Object (CISSCO) method to quantify the magnetic moments of several clusters of SPIO nanoparticle labeled cells from archived rat brain images. With the knowledge of mass magnetization of the cell labeling agent and cell iron uptake, the number of cells in each nanoparticle cluster can be determined. Using a high pass filter with a reasonable size has little effect on each measured magnetic moment from the CISSCO method. These procedures and quantitative results may help improve the efficacy of cell-based treatments in vivo.

journal_name

Magn Reson Imaging

journal_title

Magnetic resonance imaging

authors

Kokeny P,Cheng YN,Liu S,Xie H,Jiang Q

doi

10.1016/j.mri.2016.08.003

subject

Has Abstract

pub_date

2017-01-01 00:00:00

pages

141-147

eissn

0730-725X

issn

1873-5894

pii

S0730-725X(16)30108-4

journal_volume

35

pub_type

杂志文章

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