In vivo MR evaluation of Gd-DTPA conjugated to dextran in normal rabbits.

Abstract:

:A dextran-Gd-DTPA compound has been recently synthesized utilizing 70,800 Da molecular weight dextran. This polymeric contrast agent for magnetic resonance imaging has been found chemically to be very stable and to demonstrate in vitro improved relaxivities of 1.5 to 2.3 times that of monomeric Gd-DTPA at 100 MHz. This MR experiment examines the in vivo distribution and relaxivity of the 70,800 Da molecular weight dextran-Gd-DTPA compound in a rabbit model by measuring the change in signal-to-noise ratio of a variety of organs (renal cortex, renal medulla, liver, brain, and torcula herophile) compared to the preinjection state. Results demonstrate prolonged (beyond 60 min) enhancement of the renal cortex, renal medulla, liver and torcula, and no enhancement of brain parenchyma.

journal_name

Magn Reson Imaging

authors

Li KC,Quisling RG,Armitage FE,Richardson D,Mladinich C

doi

10.1016/0730-725x(92)90515-2

subject

Has Abstract

pub_date

1992-01-01 00:00:00

pages

439-44

issue

3

eissn

0730-725X

issn

1873-5894

pii

0730-725X(92)90515-2

journal_volume

10

pub_type

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