Abstract：
:The sensitivity of multiple diffusion MRI (dMRI) parameters to longitudinal changes in white matter microstructure was investigated for the 3xTg-AD transgenic mouse model of Alzheimer's disease, which manifests both amyloid beta plaques and neurofibrillary tangles. By employing a specific dMRI method known as diffusional kurtosis imaging, eight different diffusion parameters were quantified to characterize distinct aspects of water diffusion. Four female 3xTg-AD mice were imaged at five time points, ranging from 4.5 to 18 months of age, and the diffusion parameters were investigated in four white matter regions (fimbria, external capsule, internal capsule and corpus callosum). Significant changes were observed in several diffusion parameters, particularly in the fimbria and in the external capsule, with a statistically significant decrease in diffusivity and a statistically significant increase in kurtosis. Our preliminary results demonstrate that dMRI can detect microstructural changes in white matter for the 3xTg-AD mouse model due to aging and/or progression of pathology, depending strongly on the diffusion parameter and anatomical region.
journal_name
Magn Reson Imagingjournal_title
Magnetic resonance imagingauthors
Nie X,Falangola MF,Ward R,McKinnon ET,Helpern JA,Nietert PJ,Jensen JHdoi
10.1016/j.mri.2018.12.003subject
Has Abstractpub_date
2019-04-01 00:00:00pages
235-242eissn
0730-725Xissn
1873-5894pii
S0730-725X(18)30465-Xjournal_volume
57pub_type
杂志文章abstract：:With the recent development of integrated positron emission tomography-magnetic resonance imaging (PET-MRI) scanners, new possibilities for quantitative molecular imaging of cancer are realized. However, the practical advantages and potential clinical benefits of the ability to record PET and MRI data simultaneously m...
journal_title：Magnetic resonance imaging
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abstract：PURPOSE:To analyze several histopathological features and their possible correlations with whole lesion histogram analysis derived from ADC maps in meningioma. MATERIALS AND METHODS:The retrospective study involved 36 patients with primary meningiomas. For every tumor, the following histogram analysis parameters of ap...
journal_title：Magnetic resonance imaging
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journal_title：Magnetic resonance imaging
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journal_title：Magnetic resonance imaging
pub_type： 杂志文章
doi：10.1016/s0730-725x(97)00012-x
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journal_title：Magnetic resonance imaging
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journal_title：Magnetic resonance imaging
pub_type： 杂志文章
doi：10.1016/j.mri.2007.01.116
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journal_title：Magnetic resonance imaging
pub_type： 杂志文章
doi：10.1016/j.mri.2004.01.013
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journal_title：Magnetic resonance imaging
pub_type： 杂志文章
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journal_title：Magnetic resonance imaging
pub_type： 杂志文章,评审
doi：10.1016/j.mri.2006.11.023
更新日期：2007-05-01 00:00:00
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journal_title：Magnetic resonance imaging
pub_type： 杂志文章
doi：10.1016/s0730-725x(00)00165-x
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journal_title：Magnetic resonance imaging
pub_type： 杂志文章
doi：10.1016/0730-725x(89)90706-6
更新日期：1989-03-01 00:00:00
abstract：PURPOSE:This study aimed to establish the topographical and zonal T2 patterns of multi-resolution MRI in medial tibial cartilage in a canine model of osteoarthritis (OA), initiated by the anterior cruciate ligament (ACL) transection surgery, and studied after 8-weeks and 12-weeks post-surgery. METHODS:Articular cartil...
journal_title：Magnetic resonance imaging
pub_type： 杂志文章
doi：10.1016/j.mri.2021.01.002
更新日期：2021-01-22 00:00:00
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journal_title：Magnetic resonance imaging
pub_type： 杂志文章
doi：10.1016/j.mri.2018.06.009
更新日期：2018-12-01 00:00:00
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journal_title：Magnetic resonance imaging
pub_type： 杂志文章
doi：10.1016/j.mri.2016.12.006
更新日期：2017-05-01 00:00:00
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journal_title：Magnetic resonance imaging
pub_type： 杂志文章
doi：10.1016/s0730-725x(96)00110-5
更新日期：1996-01-01 00:00:00
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journal_title：Magnetic resonance imaging
pub_type： 杂志文章
doi：10.1016/j.mri.2014.04.003
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journal_title：Magnetic resonance imaging
pub_type： 杂志文章
doi：10.1016/0730-725x(95)02110-f
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journal_title：Magnetic resonance imaging
pub_type： 杂志文章
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journal_title：Magnetic resonance imaging
pub_type： 杂志文章
doi：10.1016/s0730-725x(97)00020-9
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journal_title：Magnetic resonance imaging
pub_type： 杂志文章
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journal_title：Magnetic resonance imaging
pub_type： 杂志文章
doi：10.1016/j.mri.2020.02.004
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journal_title：Magnetic resonance imaging
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journal_title：Magnetic resonance imaging
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journal_title：Magnetic resonance imaging
pub_type： 杂志文章
doi：10.1016/j.mri.2017.05.004
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journal_title：Magnetic resonance imaging
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journal_title：Magnetic resonance imaging
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journal_title：Magnetic resonance imaging
pub_type： 杂志文章
doi：10.1016/j.mri.2014.04.018
更新日期：2014-09-01 00:00:00
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journal_title：Magnetic resonance imaging
pub_type： 杂志文章
doi：10.1016/0730-725x(88)90125-7
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