Topographical and zonal patterns of T2 relaxation in osteoarthritic tibial cartilage by low- and high-resolution MRI.

Abstract:

PURPOSE:This study aimed to establish the topographical and zonal T2 patterns of multi-resolution MRI in medial tibial cartilage in a canine model of osteoarthritis (OA), initiated by the anterior cruciate ligament (ACL) transection surgery, and studied after 8-weeks and 12-weeks post-surgery. METHODS:Articular cartilage from healthy, two stages of contralateral, and of OA knees were quantitatively imaged by the MRI T2 protocols at two imaging resolutions (100 and 17.6 μm/pixel). The zonal T2 changes at five topographical locations (anterior (AMT), exterior (EMT), posterior (PMT), central (CMT) and interior (IMT) medial tibia) and subsequent two averaged regions (covered by meniscus and exposed) were analyzed. At each location, full-thickness cartilage was studied in four sub-tissue zones (superficial, transitional, upper and lower radial zones). RESULTS:Tissue degradation can be detected by measurable changes of T2, which is resolution- and orientation-dependent. T2 changes ranging from +28.82% increase (SZ, PMT) to -23.15% decrease (RZ1, AMT) in healthy to disease (8C), with the largest increase of T2 in the surface tissue. Various location-dependent patterns of degradation are found over the tibial surface, most commonly shown in early-stage OA (8C) on the anterior site, different from the posterior. Finally, the contralateral cartilage has specific degradation patterns, different from those in OA cartilage. CONCLUSIONS:This is the first quantitative and highest multi-resolution characterization of cartilage at five topographical locations over the medial tibial plateau with fine zonal resolution in an animal model of OA, which would benefit future investigation of human OA in clinics.

journal_name

Magn Reson Imaging

authors

Badar F,Lee J,Qu X,Xia Y

doi

10.1016/j.mri.2021.01.002

subject

Has Abstract

pub_date

2021-01-22 00:00:00

eissn

0730-725X

issn

1873-5894

pii

S0730-725X(21)00003-5

pub_type

杂志文章
  • STrategically Acquired Gradient Echo (STAGE) imaging, part II: Correcting for RF inhomogeneities in estimating T1 and proton density.

    abstract:PURPOSE:To develop a method for mapping the B1 transmit (B1t) and B1 receive (B1r) fields from two gradient echo datasets each with a different flip angle and from these two images obtain accurate T1 and proton density (PD) maps of the brain. METHODS:A strategically acquired gradient echo (STAGE) data set is collected...

    journal_title:Magnetic resonance imaging

    pub_type: 杂志文章

    doi:10.1016/j.mri.2017.10.006

    authors: Wang Y,Chen Y,Wu D,Wang Y,Sethi SK,Yang G,Xie H,Xia S,Haacke EM

    更新日期:2018-02-01 00:00:00

  • MR imaging of cervical spine motion with HASTE.

    abstract::The HASTE (half-Fourier acquisition single-shot turbo spin-echo) technique delivers images with T2-weighting in about half a second and could be ideal for fast dynamic studies when T2-weighting is needed. We evaluated cardiac-triggered HASTE to study cervical spine flexion/extension. The cervical spines of ten asympto...

    journal_title:Magnetic resonance imaging

    pub_type: 杂志文章

    doi:10.1016/s0730-725x(98)00176-3

    authors: Duerinckx AJ,Yu WD,El-Saden S,Kim D,Wang JC,Sandhu HS

    更新日期:1999-04-01 00:00:00

  • Evidence for left-right asymmetries in the proton MRS of brain in normal volunteers.

    abstract::Although there is ample evidence in the literature for structural, functional and physiological asymmetries in the two hemispheres of human brain, direct evidence of a similar asymmetry in the in vivo distribution of brain metabolites has been lacking. In this study, the existence of chemical asymmetries in six differ...

    journal_title:Magnetic resonance imaging

    pub_type: 杂志文章

    doi:10.1016/s0730-725x(96)00342-6

    authors: Jayasundar R,Raghunathan P

    更新日期:1997-01-01 00:00:00

  • Assessment of extravascular extracellular space fraction in human melanoma xenografts by DCE-MRI and kinetic modeling.

    abstract::Tumor aggressiveness and response to therapy are influenced by the extravascular extracellular space fraction (EESF) of the malignant tissue. The EESF may, therefore, be an important prognostic parameter for cancer patients. The aim of this study was to investigate whether gadopentetate dimeglumine (Gd-DTPA)-based dyn...

    journal_title:Magnetic resonance imaging

    pub_type: 杂志文章

    doi:10.1016/j.mri.2007.06.003

    authors: Benjaminsen IC,Brurberg KG,Ruud EB,Rofstad EK

    更新日期:2008-02-01 00:00:00

  • Fast and exact flow measurements with the fast Fourier flow technique.

    abstract::The fast Fourier flow technique offers a convenient way for extremely exact flow measurements. In combination with ECG gating, arterial flow can be studied. The total acquisition time for a single measurement is about 10 s, an ECG-gated cine sequence can be acquired in about 4 min. Fast Fourier flow can, therefore, be...

    journal_title:Magnetic resonance imaging

    pub_type: 杂志文章

    doi:10.1016/0730-725x(88)90473-0

    authors: Hennig J,Mueri M,Brunner P,Friedburg H

    更新日期:1988-07-01 00:00:00

  • A robust electrical conductivity imaging method with total variation and wavelet regularization.

    abstract:PURPOSE:This study aims to develop and evaluate a robust conductivity imaging method that combines total variation and wavelet regularization to enhance the accuracy of conductivity maps. THEORY AND METHODS:The proposed approach is based on a gradient-based method. The central equation is derived from Maxwell's equati...

    journal_title:Magnetic resonance imaging

    pub_type: 杂志文章

    doi:10.1016/j.mri.2020.02.015

    authors: Sun X,Lu L,Qi L,Mei Y,Liu X,Chen W

    更新日期:2020-06-01 00:00:00

  • Spine MR images in patients with pedicle screw fixation: Comparison of conventional and SEMAC-VAT sequences at 1.5 T.

    abstract:BACKGROUND AND PURPOSE:Slice-encoding metal artifact corrections (SEMAC)-view-angle tilting (VAT) sequences have recently been used in clinical protocols to reduce metal artifacts in MR scans of patients with spinal instrumentation. The objective of this study was to compare the SEMAC-VAT sequence with the conventional...

    journal_title:Magnetic resonance imaging

    pub_type: 杂志文章

    doi:10.1016/j.mri.2018.08.002

    authors: Park C,Lee E,Yeo Y,Kang Y,Lee JW,Ahn JM,Kang HS

    更新日期:2018-12-01 00:00:00

  • Quantitation of normal canine hippocampus formation volume: correlation of MRI with gross histology.

    abstract::The hippocampal formation possesses an important role in the development and maintenance of short-term memory. In this study, magnetic resonance imaging (MRI) and gross histology were used to quantify the volume of the hippocampal formation in canines. High resolution MRI, using 1 mm thick slices and an intraplanar re...

    journal_title:Magnetic resonance imaging

    pub_type: 杂志文章

    doi:10.1016/0730-725x(95)02083-6

    authors: Vullo T,Deo-Narine V,Stallmeyer MJ,Gomez DG,Cahill PT

    更新日期:1996-01-01 00:00:00

  • Computerized quantification of carotid artery stenosis using MRA axial images.

    abstract::Currently, the North American symptomatic carotid endarterectomy trial, European carotid surgery trial, and common carotid method are used to measure the carotid stenosis for determining candidates for carotid endarterectomy using the projection angiography from different modalities such as digital subtraction angiogr...

    journal_title:Magnetic resonance imaging

    pub_type: 杂志文章

    doi:10.1016/j.mri.2004.01.007

    authors: Kim DY,Park JW

    更新日期:2004-04-01 00:00:00

  • A new method for diffusion weighted imaging.

    abstract::A new method for generating diffusion contrast in magnetic resonance imaging is presented. This technique is robust enough to allow implementation on conventional imaging systems without hardware modifications. Results from phantom measurements are reported. Qualitative contrast changes in magnetic resonance images de...

    journal_title:Magnetic resonance imaging

    pub_type: 杂志文章

    doi:10.1016/0730-725x(93)90069-p

    authors: Norwood TJ,Williams SC

    更新日期:1993-01-01 00:00:00

  • Reaction of gadolinium chelates with endogenously available ions.

    abstract::The extent of reaction of 153Gd-radiolabeled Gd(L) chelates with 25 mM CO23- (25 mF), PO34-, Zn2+ and Cu2+ at pH 7 was determined for L = EDTA, DTPA, DOTA, HP-DO3A, and DO3A. Gd(EDTA)- and Gd(DTPA)2- reacted (greater than 20% in 10 min) with Cu2+ and Zn2+ in the presence of PO34-. These double replacement reactions yi...

    journal_title:Magnetic resonance imaging

    pub_type: 杂志文章

    doi:10.1016/0730-725x(91)90429-p

    authors: Tweedle MF,Hagan JJ,Kumar K,Mantha S,Chang CA

    更新日期:1991-01-01 00:00:00

  • Interpretation of restricted diffusion in sandstones with internal field gradients.

    abstract::We report on experiments to characterize internal magnetic field gradients that are caused by magnetic susceptibility differences between the solid phase and the fluids filling the pore space. Our measurements focus on low-field relaxometry of brine and oil in sandstones from various reservoirs around the world. Our r...

    journal_title:Magnetic resonance imaging

    pub_type: 杂志文章

    doi:10.1016/s0730-725x(01)00287-9

    authors: Appel M,Freeman JJ,Gardner JS,Hirasaki GH,Zhang QG,Shafer JL

    更新日期:2001-04-01 00:00:00

  • Fat ViP MRI: Virtual Phantom Magnetic Resonance Imaging of water-fat systems.

    abstract:OBJECT:Virtual Phantom Magnetic Resonance Imaging (ViP MRI) is a method to generate reference signals on MR images, using external radiofrequency (RF) signals. The aim of this study was to assess the feasibility of ViP MRI to generate complex-data images of phantoms mimicking water-fat systems. MATERIALS AND METHODS:V...

    journal_title:Magnetic resonance imaging

    pub_type: 杂志文章

    doi:10.1016/j.mri.2015.12.002

    authors: Salvati R,Hitti E,Bellanger JJ,Saint-Jalmes H,Gambarota G

    更新日期:2016-06-01 00:00:00

  • Magnetic resonance imaging: application in musculoskeletal infection.

    abstract::Forty-two patients with clinically suspected osteomyelitis were examined using magnetic resonance imaging (MRI). Twenty-seven patients (64%) had previous surgery or fracture, and 15 (36%) were referred for differentiation of acute osteomyelitis from bone tumors or other pathologic conditions. MRI was compared with com...

    journal_title:Magnetic resonance imaging

    pub_type: 杂志文章

    doi:10.1016/0730-725x(85)90350-9

    authors: Berquist TH,Brown ML,Fitzgerald RH Jr,May GR

    更新日期:1985-01-01 00:00:00

  • Removal of extracerebral tissues in dual-echo magnetic resonance images via linear scale-space features.

    abstract::The location and masking of the brain and surrounding cerebrospinal fluid (CSF) in two-dimensional (2D) dual-echo fast spin-echo (FSE) magnetic resonance (MR) images of the head is achieved by an automated procedure with a voxel-based computational algorithm. Linear scale-space features are derived from the short-echo...

    journal_title:Magnetic resonance imaging

    pub_type: 杂志文章

    doi:10.1016/s0730-725x(98)00099-x

    authors: Suckling J,Brammer MJ,Lingford-Hughes A,Bullmore ET

    更新日期:1999-02-01 00:00:00

  • Non-Gaussian diffusion MRI assessment of brain microstructure in mild cognitive impairment and Alzheimer's disease.

    abstract::We report the first application of a novel diffusion-based MRI method, called diffusional kurtosis imaging (DKI), to investigate changes in brain tissue microstructure in patients with mild cognitive impairment (MCI) and AD and in cognitively intact controls. The subject groups were characterized and compared in terms...

    journal_title:Magnetic resonance imaging

    pub_type: 杂志文章

    doi:10.1016/j.mri.2013.02.008

    authors: Falangola MF,Jensen JH,Tabesh A,Hu C,Deardorff RL,Babb JS,Ferris S,Helpern JA

    更新日期:2013-07-01 00:00:00

  • Undifferentiated (embryonal) sarcoma of the liver (USL): MRI findings including dynamic gadolinium enhancement.

    abstract::We report the MR appearance of undifferentiated (embryonal) sarcoma of the liver (USL) in a 13-year-old female who presented with a 1-year history of intermittent abdominal pain, weight loss, and fatigue. The tumor was a large, solitary, well-defined focal mass lesion with multiple cystic spaces, septations, and subst...

    journal_title:Magnetic resonance imaging

    pub_type: 杂志文章

    doi:10.1016/j.mri.2004.02.003

    authors: Psatha EA,Semelka RC,Fordham L,Firat Z,Woosley JT

    更新日期:2004-07-01 00:00:00

  • In situ magnetic resonance measurement of conversion, hydrodynamics and mass transfer during single- and two-phase flow in fixed-bed reactors.

    abstract::In recent years there has been increasing interest in applying magnetic resonance (MR) techniques in areas of engineering and chemical technology. The science that underpins many of these applications is the physics and chemistry of transport and reaction processes in porous materials. Key to the exploitation of MR me...

    journal_title:Magnetic resonance imaging

    pub_type: 杂志文章

    doi:10.1016/s0730-725x(03)00127-9

    authors: Gladden LF,Alexander P,Britton MM,Mantle MD,Sederman AJ,Yuen EH

    更新日期:2003-04-01 00:00:00

  • Synthesis of magnetic gradients for NMR tomography.

    abstract::A numerical method is applied to calculate an optimal distribution of currents in air which generate the magnetic field gradients required to spatially encode the radiofrequency signal in a NMR tomographic experiment. We compare the performances of the gradient circuits for the whole body air-core electromagnet descri...

    journal_title:Magnetic resonance imaging

    pub_type: 杂志文章

    doi:10.1016/0730-725x(90)90242-t

    authors: Mustarelli P,Rudnicki M,Savini A,Savoldi F,Villa M

    更新日期:1990-01-01 00:00:00

  • A purpose-built neck coil for black-blood DANTE-prepared carotid artery imaging at 7T.

    abstract::Atherosclerotic plaques in the bifurcation of the carotid arteries can pose a significant health risk due to possible plaque rupture and subsequent stroke. The assessment of plaques, and evaluation of the risk they pose, can be performed with Black-Blood (BB) vessel wall magnetic resonance imaging. However, resolution...

    journal_title:Magnetic resonance imaging

    pub_type: 杂志文章

    doi:10.1016/j.mri.2017.04.011

    authors: Papoutsis K,Li L,Near J,Payne S,Jezzard P

    更新日期:2017-07-01 00:00:00

  • Dual-echo breathhold T(2)-weighted fast spin echo MR imaging of liver lesions.

    abstract::The purpose of this study was to develop a multi-shot dual-echo breathhold fast spin echo technique (DFSE) and compare it with conventional spin echo (T2SE) for T(2)-weighted MR imaging of liver lesions. The DFSE acquisition (EffTE1/EffTE2/TR = 66/143/2100 ms) imaged 5 sections per 17 s breathhold. T2SE imaging (TE1/T...

    journal_title:Magnetic resonance imaging

    pub_type: 杂志文章

    doi:10.1016/s0730-725x(99)00120-4

    authors: Rydberg JN,Tervonen OA,Rydberg DB,Lomas DJ,Ehman RL,Riederer SJ

    更新日期:2000-02-01 00:00:00

  • Evaluation of EPI distortion correction methods for quantitative MRI of the brain at high magnetic field.

    abstract::High field MRI has been applied to high-resolution structural and functional imaging of the brain. Echo planar imaging (EPI) is an ultrafast acquisition technique widely used in diffusion imaging, functional MRI and perfusion imaging. However, it suffers from geometric and intensity distortions caused by static magnet...

    journal_title:Magnetic resonance imaging

    pub_type: 杂志文章

    doi:10.1016/j.mri.2015.06.010

    authors: Hong X,To XV,Teh I,Soh JR,Chuang KH

    更新日期:2015-11-01 00:00:00

  • Rapid assessment of regional and global left ventricular function using three-dimensional k-t BLAST imaging.

    abstract:OBJECTIVE:To test if three-dimensional (3D) cine spatial frequency-temporal frequency Broad-use Linear Acquisition Speed-up Technique (k-t BLAST) is suitable for rapid evaluation of global and regional left ventricular (LV) functional parameters and to evaluate the influence of gadolinium administration. MATERIALS AND...

    journal_title:Magnetic resonance imaging

    pub_type: 杂志文章

    doi:10.1016/j.mri.2008.01.027

    authors: Huber S,Muthupillai R,Mojibian H,Cheong B,Kouwenhoven M,Flamm SD

    更新日期:2008-07-01 00:00:00

  • Trajectory correction for free-breathing radial cine MRI.

    abstract::Radial acquisitions can suffer from trajectory errors leading to reduced image quality. Here we present a new method of trajectory correction that uses all spokes of a radial acquisition and compare it to an existing method that uses a two-spoke pre-scan calibration. For both methods, estimates of the necessary shifts...

    journal_title:Magnetic resonance imaging

    pub_type: 杂志文章

    doi:10.1016/j.mri.2014.04.006

    authors: Buonincontri G,Methner C,Krieg T,Carpenter TA,Sawiak SJ

    更新日期:2014-09-01 00:00:00

  • MRI studies of the neurotoxic effects of L-2-chloropropionic acid on rat brain.

    abstract::L-2-Chloropropionic acid (L-CPA) is selectively toxic to rat cerebellar granule cells; necrosis is first observed about 36 hours after administration of L-CPA (750 mg/kg p.o.) becoming more marked by 48 h. Parallel to the onset of cell death an increase in cerebellar water content and sodium concentration has been rep...

    journal_title:Magnetic resonance imaging

    pub_type: 杂志文章

    doi:10.1016/s0730-725x(01)00231-4

    authors: Williams RE,Prior M,Bachelard HS,Waterton JC,Checkley D,Lock EA

    更新日期:2001-02-01 00:00:00

  • Active intrahepatic gadolinium extravasation following TIPS.

    abstract::A 31-year-old male patient had a transjugular intrahepatic portal systemic shunt (TIPS) placed for acute Budd-Chiari syndrome secondary to paroxysmal nocturnal hemoglobinuria (PNH). Post-procedure, he was anticoagulated for his underlying paroxysmal nocturnal hemoglobinuria. After 11 days, he complained of upper abdom...

    journal_title:Magnetic resonance imaging

    pub_type: 杂志文章

    doi:10.1016/s0730-725x(98)00081-2

    authors: Hasegawa S,Eisenberg LB,Semelka RC

    更新日期:1998-09-01 00:00:00

  • Selective microvascular muscle perfusion imaging in the shoulder with intravoxel incoherent motion (IVIM).

    abstract::The evaluation of local muscle recruitment during a specific movement can be done indirectly by measuring changes in local blood flow. Intravoxel incoherent motion perfusion imaging exploits some properties of the magnetic resonance to measure locally microvascular perfusion, and seems ideally suited for this task. We...

    journal_title:Magnetic resonance imaging

    pub_type: 杂志文章

    doi:10.1016/j.mri.2016.08.005

    authors: Nguyen A,Ledoux JB,Omoumi P,Becce F,Forget J,Federau C

    更新日期:2017-01-01 00:00:00

  • A simple noise correction scheme for diffusional kurtosis imaging.

    abstract:PURPOSE:Diffusional kurtosis imaging (DKI) is sensitive to the effects of signal noise due to strong diffusion weightings and higher order modeling of the diffusion weighted signal. A simple noise correction scheme is proposed to remove the majority of the noise bias in the estimated diffusional kurtosis. METHODS:Weig...

    journal_title:Magnetic resonance imaging

    pub_type: 杂志文章

    doi:10.1016/j.mri.2014.08.028

    authors: Glenn GR,Tabesh A,Jensen JH

    更新日期:2015-01-01 00:00:00

  • Voxel-Wise Logistic Regression and Leave-One-Source-Out Cross Validation for white matter hyperintensity segmentation.

    abstract::Many algorithms have been proposed for automated segmentation of white matter hyperintensities (WMH) in brain MRI. Yet, broad uptake of any particular algorithm has not been observed. In this work, we argue that this may be due to variable and suboptimal validation data and frameworks, precluding direct comparison of ...

    journal_title:Magnetic resonance imaging

    pub_type: 杂志文章

    doi:10.1016/j.mri.2018.06.009

    authors: Knight J,Taylor GW,Khademi A

    更新日期:2018-12-01 00:00:00

  • Magnetic resonance imaging of mouse Ehrlich carcinoma growth inhibition by thiacarpine, an analogue of cytotoxic marine alkaloid polycarpine.

    abstract::The anticancer effect of thiacarpine, a synthetic analogue of the known cytotoxic alkaloid polycarpine isolated from the Pacific ascidian Polycarpa aurata, was investigated in vivo in experiments using mouse solid Ehrlich carcinoma tumor as the target. A high-resolution magnetic resonance imaging (MRI) technique using...

    journal_title:Magnetic resonance imaging

    pub_type: 杂志文章

    doi:10.1016/j.mri.2008.01.014

    authors: Agafonova IG,Radchenko OS,Novikov VL,Aminin DL,Stonik VA

    更新日期:2008-07-01 00:00:00