Abstract:
PURPOSE:This study aimed to establish the topographical and zonal T2 patterns of multi-resolution MRI in medial tibial cartilage in a canine model of osteoarthritis (OA), initiated by the anterior cruciate ligament (ACL) transection surgery, and studied after 8-weeks and 12-weeks post-surgery. METHODS:Articular cartilage from healthy, two stages of contralateral, and of OA knees were quantitatively imaged by the MRI T2 protocols at two imaging resolutions (100 and 17.6 μm/pixel). The zonal T2 changes at five topographical locations (anterior (AMT), exterior (EMT), posterior (PMT), central (CMT) and interior (IMT) medial tibia) and subsequent two averaged regions (covered by meniscus and exposed) were analyzed. At each location, full-thickness cartilage was studied in four sub-tissue zones (superficial, transitional, upper and lower radial zones). RESULTS:Tissue degradation can be detected by measurable changes of T2, which is resolution- and orientation-dependent. T2 changes ranging from +28.82% increase (SZ, PMT) to -23.15% decrease (RZ1, AMT) in healthy to disease (8C), with the largest increase of T2 in the surface tissue. Various location-dependent patterns of degradation are found over the tibial surface, most commonly shown in early-stage OA (8C) on the anterior site, different from the posterior. Finally, the contralateral cartilage has specific degradation patterns, different from those in OA cartilage. CONCLUSIONS:This is the first quantitative and highest multi-resolution characterization of cartilage at five topographical locations over the medial tibial plateau with fine zonal resolution in an animal model of OA, which would benefit future investigation of human OA in clinics.
journal_name
Magn Reson Imagingjournal_title
Magnetic resonance imagingauthors
Badar F,Lee J,Qu X,Xia Ydoi
10.1016/j.mri.2021.01.002subject
Has Abstractpub_date
2021-01-22 00:00:00eissn
0730-725Xissn
1873-5894pii
S0730-725X(21)00003-5pub_type
杂志文章abstract:PURPOSE:To develop a method for mapping the B1 transmit (B1t) and B1 receive (B1r) fields from two gradient echo datasets each with a different flip angle and from these two images obtain accurate T1 and proton density (PD) maps of the brain. METHODS:A strategically acquired gradient echo (STAGE) data set is collected...
journal_title:Magnetic resonance imaging
pub_type: 杂志文章
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abstract::The HASTE (half-Fourier acquisition single-shot turbo spin-echo) technique delivers images with T2-weighting in about half a second and could be ideal for fast dynamic studies when T2-weighting is needed. We evaluated cardiac-triggered HASTE to study cervical spine flexion/extension. The cervical spines of ten asympto...
journal_title:Magnetic resonance imaging
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journal_title:Magnetic resonance imaging
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journal_title:Magnetic resonance imaging
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journal_title:Magnetic resonance imaging
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journal_title:Magnetic resonance imaging
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journal_title:Magnetic resonance imaging
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journal_title:Magnetic resonance imaging
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journal_title:Magnetic resonance imaging
pub_type: 杂志文章
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更新日期:2013-07-01 00:00:00
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journal_title:Magnetic resonance imaging
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更新日期:2008-07-01 00:00:00
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更新日期:2001-02-01 00:00:00
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更新日期:2017-01-01 00:00:00
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更新日期:2015-01-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/j.mri.2018.06.009
更新日期:2018-12-01 00:00:00
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doi:10.1016/j.mri.2008.01.014
更新日期:2008-07-01 00:00:00