Abstract:
:Dynamic contrast-enhanced magnetic resonance imaging (MRI) is widely used for measuring perfusion and blood volume, especially cerebral blood volume (CBV). In case of blood-brain barrier (BBB) disruption, the conventional techniques only partially determine the pharmacokinetic parameters of contrast medium (CM) exchange between different compartments. Here a modified pharmacokinetic model is applied, which is based on the bidirectional CM exchange between blood and two interstitial compartments in terms of the fractional volumes of the compartments and the vessel permeabilities between them. The evaluation technique using this model allows one to quantify the fractional volumes of the different compartments (blood, cells, slowly and fast enhancing interstitium) as well as the vessel permeabilities and cerebral blood flow (CBF) with a single T1-weighted dynamic MRI measurement. The method has been successfully applied in 25 glioma patients for generating maps of all of these parameters. The fractional volume maps allow for the differentiation of glioma vascularization types. The maps show a good correlation with the histological grading of these tumors. Furthermore, regions with enhanced interstitial volumes are found in high-grade gliomas. Differences in permeability maps of Gd-DTPA apart from BBB disruption do not exist between different tissue types. CBF measured in high-grade glioma is less pronounced than it would be expected from their blood volume. Therefore pharmacokinetic imaging provides an additional tool for glioma characterization.
journal_name
Magn Reson Imagingjournal_title
Magnetic resonance imagingauthors
Lüdemann L,Hamm B,Zimmer Cdoi
10.1016/s0730-725x(00)00223-xsubject
Has Abstractpub_date
2000-12-01 00:00:00pages
1201-14issue
10eissn
0730-725Xissn
1873-5894pii
S0730725X0000223Xjournal_volume
18pub_type
杂志文章abstract:BACKGROUND:Doppler based mitral annular velocities are an integral part of echocardiographic left ventricular diastolic function assessment. Although these measurements can be obtained by phase contrast cardiac magnetic resonance imaging (PC-CMR), this approach has limitations. The aims of this study were to assess the...
journal_title:Magnetic resonance imaging
pub_type: 杂志文章
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更新日期:2019-01-01 00:00:00
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journal_title:Magnetic resonance imaging
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journal_title:Magnetic resonance imaging
pub_type: 杂志文章
doi:10.1016/0730-725x(95)00010-e
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journal_title:Magnetic resonance imaging
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journal_title:Magnetic resonance imaging
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journal_title:Magnetic resonance imaging
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journal_title:Magnetic resonance imaging
pub_type: 杂志文章
doi:10.1016/j.mri.2016.10.006
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journal_title:Magnetic resonance imaging
pub_type: 杂志文章
doi:10.1016/j.mri.2014.08.041
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journal_title:Magnetic resonance imaging
pub_type: 杂志文章
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journal_title:Magnetic resonance imaging
pub_type: 杂志文章
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更新日期:1990-01-01 00:00:00
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journal_title:Magnetic resonance imaging
pub_type: 杂志文章
doi:10.1016/0730-725x(85)90006-2
更新日期:1985-01-01 00:00:00
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journal_title:Magnetic resonance imaging
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doi:10.1016/j.mri.2003.01.001
更新日期:2004-01-01 00:00:00
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journal_title:Magnetic resonance imaging
pub_type: 杂志文章
doi:10.1016/0730-725x(95)00018-c
更新日期:1995-01-01 00:00:00
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journal_title:Magnetic resonance imaging
pub_type: 杂志文章
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更新日期:2016-02-01 00:00:00
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journal_title:Magnetic resonance imaging
pub_type: 杂志文章
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更新日期:2017-12-01 00:00:00
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journal_title:Magnetic resonance imaging
pub_type: 杂志文章
doi:10.1016/j.mri.2017.07.012
更新日期:2017-12-01 00:00:00
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journal_title:Magnetic resonance imaging
pub_type: 杂志文章
doi:10.1016/j.mri.2017.12.029
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journal_title:Magnetic resonance imaging
pub_type: 杂志文章
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journal_title:Magnetic resonance imaging
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journal_title:Magnetic resonance imaging
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journal_title:Magnetic resonance imaging
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journal_title:Magnetic resonance imaging
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journal_title:Magnetic resonance imaging
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journal_title:Magnetic resonance imaging
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更新日期:2008-05-01 00:00:00
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journal_title:Magnetic resonance imaging
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journal_title:Magnetic resonance imaging
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journal_title:Magnetic resonance imaging
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journal_title:Magnetic resonance imaging
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