Gadolinium toxicity: Iron and ferroportin as central targets.

Abstract:

:Gadolinium-based magnetic resonance (MR) contrast agents (GBCM) causes a devastating systemic fibrosing illness, nephrogenic systemic fibrosis (NSF), in patients with reduced kidney function. GBCM targets iron-recycling CD163- and ferroportin-expressing macrophages to release labile iron that mediates gadolinium toxicity and NSF. GBCA might similarly target iron-rich, ferroportin-expressing structures such as globus pallidus and cerebellar dentate nucleus in the brain to result in metal accumulation and potential toxicity.

journal_name

Magn Reson Imaging

authors

Swaminathan S

doi

10.1016/j.mri.2016.08.016

subject

Has Abstract

pub_date

2016-12-01 00:00:00

pages

1373-1376

issue

10

eissn

0730-725X

issn

1873-5894

pii

S0730-725X(16)30121-7

journal_volume

34

pub_type

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