Effect of slice orientation on reproducibility of fMRI motor activation at 3 Tesla.

Abstract:

:The effect of slice orientation on reproducibility and sensitivity of 3T fMRI activation using a motor task has been investigated in six normal volunteers. Four slice orientations were used; axial, oblique axial, coronal and sagittal. We applied analysis of variance (ANOVA) to suprathreshold voxel statistics to quantify variability in activation between orientations and between subjects. We also assessed signal detection accuracy in voxels across the whole brain by using a finite mixture model to fit receiver operating characteristic (ROC) curves to the data. Preliminary findings suggest that suprathreshold cluster characteristics demonstrate high motor reproducibility across subjects and orientations, although a significant difference between slice orientations in number of activated voxels was demonstrated in left motor cortex but not cerebellum. Subtle inter-orientation differences are highlighted in the ROC analyses, which are not obvious by ANOVA; the oblique axial slice orientation offers the highest signal detection accuracy, whereas coronal slices give the lowest.

journal_name

Magn Reson Imaging

authors

Gustard S,Fadili J,Williams EJ,Hall LD,Carpenter TA,Brett M,Bullmore ET

doi

10.1016/s0730-725x(01)00399-x

subject

Has Abstract

pub_date

2001-12-01 00:00:00

pages

1323-31

issue

10

eissn

0730-725X

issn

1873-5894

pii

S0730725X0100399X

journal_volume

19

pub_type

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