Abstract:
OBJECTIVES:The objectives of this study were to develop protocols that measure abdominal fat and calf muscle lipids with magnetic resonance imaging (MRI) and magnetic resonance spectroscopy (MRS), respectively, at 3 T and to examine the correlation between these parameters and insulin sensitivity. MATERIALS AND METHODS:Ten nondiabetic subjects [five insulin-sensitive (IS) subjects and five insulin-resistant (IR) subjects] were scanned at 3 T. Visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) were segmented semiautomatically from abdominal imaging. Intramyocellular lipids (IMCL) in calf muscles were quantified with single-voxel MRS in both soleus and tibialis anterior muscles and with magnetic resonance spectroscopic imaging (MRSI). RESULTS:The average coefficient of variation (CV) of VAT/(VAT+SAT) was 5.2%. The interoperator CV was 1.1% and 5.3% for SAT and VAT estimates, respectively. The CV of IMCL was 13.7% in soleus, 11.9% in tibialis anterior and 2.9% with MRSI. IMCL based on MRSI (3.8+/-1.2%) were significantly inversely correlated with glucose disposal rate, as measured by a hyperinsulinemic-euglycemic clamp. VAT volume correlated significantly with IMCL. IMCL based on MRSI for IR subjects was significantly greater than that for IS subjects (4.5+/-0.9% vs. 2.8+/-0.5%, P=.02). CONCLUSION:MRI and MRS techniques provide a robust noninvasive measurement of abdominal fat and muscle IMCL, which are correlated with insulin action in humans.
journal_name
Magn Reson Imagingjournal_title
Magnetic resonance imagingauthors
Li X,Youngren JF,Hyun B,Sakkas GK,Mulligan K,Majumdar S,Masharani UB,Schambelan M,Goldfine IDdoi
10.1016/j.mri.2007.06.006subject
Has Abstractpub_date
2008-02-01 00:00:00pages
188-97issue
2eissn
0730-725Xissn
1873-5894pii
S0730-725X(07)00312-8journal_volume
26pub_type
杂志文章abstract::The midcalf muscles of eight patients who had peripheral arterial occlusive disease were evaluated by exercise MRI before and after bypass surgery or percutaneous transluminal angioplasty. MRI showed a high intensity of these muscles, especially the posterior muscles, after exercise in all patients before intervention...
journal_title:Magnetic resonance imaging
pub_type: 杂志文章
doi:10.1016/0730-725x(95)00018-c
更新日期:1995-01-01 00:00:00
abstract::Neurovascular coupling describes the cascade between neuronal activity and subsequent Blood-Oxygenation-Level-Dependent (BOLD) signal increase. Based on this premise, the correlation of this BOLD signal increase with a particular task, such as finger-tapping, is used to map neuronal activation. This signal increase ma...
journal_title:Magnetic resonance imaging
pub_type: 杂志文章
doi:10.1016/j.mri.2018.02.002
更新日期:2018-06-01 00:00:00
abstract:PURPOSE:Our study aimed to develop accelerated microscopic diffusional kurtosis imaging (μDKI) and preliminarily evaluated it in a rodent model of chronic epilepsy. METHODS:We investigated two μDKI acceleration schemes of reduced sampling density and angular range in a phantom and wild-type rats, and further tested μD...
journal_title:Magnetic resonance imaging
pub_type: 杂志文章
doi:10.1016/j.mri.2018.10.009
更新日期:2019-02-01 00:00:00
abstract::Echo planar imaging (EPI) was extended for the acquisition of both, the spin-echo (SE) and the stimulated echo in a stimulated echo sequence after one excitation from thermal equilibrium. The two independent EPI images reflect different states of the transverse magnetization excited and measured almost simultaneously....
journal_title:Magnetic resonance imaging
pub_type: 杂志文章
doi:10.1016/0730-725x(94)91234-n
更新日期:1994-01-01 00:00:00
abstract::Pulsed field gradient (PFG) nuclear magnetic resonance (NMR) and microimaging experiments have been performed to study the diffusion of liquid alkanes into a variety of semicrystalline polyethylene (PE) samples. The results highlight the importance of the crystalline phase in controlling the diffusion process in terms...
journal_title:Magnetic resonance imaging
pub_type: 杂志文章
doi:10.1016/s0730-725x(98)00032-0
更新日期:1998-06-01 00:00:00
abstract:PURPOSE:To develop a method for mapping the B1 transmit (B1t) and B1 receive (B1r) fields from two gradient echo datasets each with a different flip angle and from these two images obtain accurate T1 and proton density (PD) maps of the brain. METHODS:A strategically acquired gradient echo (STAGE) data set is collected...
journal_title:Magnetic resonance imaging
pub_type: 杂志文章
doi:10.1016/j.mri.2017.10.006
更新日期:2018-02-01 00:00:00
abstract:PURPOSE:To implement and evaluate interleaved blip-up, blip-down, non-segmented 3D echo planar imaging (EPI) with pseudo-continuous arterial spin labeling (pCASL) and post-processing for reduced susceptibility artifact cerebral blood flow (CBF) maps. MATERIALS AND METHODS:3D EPI non-segmented acquisition with a pCASL ...
journal_title:Magnetic resonance imaging
pub_type: 杂志文章
doi:10.1016/j.mri.2017.08.011
更新日期:2017-12-01 00:00:00
abstract::Before it is possible to use MR imaging to investigate changes in the hippocampus in disease processes such as epilepsy and memory disorders, it is imperative that normal variations are defined. Using specific anatomic locations, we evaluated the hippocampi of 29 normal volunteers with coronal MR studies. Mild variati...
journal_title:Magnetic resonance imaging
pub_type: 杂志文章
doi:10.1016/0730-725x(91)90035-k
更新日期:1991-01-01 00:00:00
abstract::Biexponential T(2) relaxation of the localized water signal can be used for segmentation of spectroscopic volumes. To assess the specificity of the components an iterative relaxation measurement of the localized water signal (STEAM, 12 echo times, geometric spacing from 30 ms to 2000 ms) was combined with magnetizatio...
journal_title:Magnetic resonance imaging
pub_type: 杂志文章
doi:10.1016/s0730-725x(01)00396-4
更新日期:2001-07-01 00:00:00
abstract::In congenital diaphragmatic hernia (CDH), lung hypoplasia and secondary pulmonary hypertension are the major causes of death and severe disability. Based on new therapeutic strategies survival rates could be improved to up to 80%. However, after surgical repair of CDH, long-term follow-up of these pediatric patients i...
journal_title:Magnetic resonance imaging
pub_type: 杂志文章
doi:10.1016/j.mri.2015.08.003
更新日期:2015-12-01 00:00:00
abstract::The successful use of magnetic resonance imaging (MRI) of a moldic fossil dicynodont from the Permian aeolian Hopeman Sandstone Formation of Elgin, Scotland, UK, provides paleontologists with a nondestructive technique for examining fossils preserved in this fashion. For large moldic fossils, medical scanners such as ...
journal_title:Magnetic resonance imaging
pub_type: 杂志文章
doi:10.1016/j.mri.2003.09.006
更新日期:2004-02-01 00:00:00
abstract::The radiologic findings from 60 patients with 86 internally deranged temporomandibular joints (TMJ) upon whom sequential imaging procedures had been performed over a period of two months to ten years were analyzed and correlated with clinical, surgical (72 joints), and pathological observations. Internal derangement o...
journal_title:Magnetic resonance imaging
pub_type: 杂志文章
doi:10.1016/0730-725x(89)90404-9
更新日期:1989-09-01 00:00:00
abstract::New methods for acquiring and processing gradient NMR well log data enable signals from gas, light oil, and water to be unambiguously separated and, in many cases, quantified. These methods exploit the combined effects of T1-based and diffusion-based contrast on log response. T1 contrast, which separates the water and...
journal_title:Magnetic resonance imaging
pub_type: 杂志文章
doi:10.1016/s0730-725x(96)00162-2
更新日期:1996-01-01 00:00:00
abstract::Surface magnetic relaxation in porous media is usually attributed to hindered rotation or to paramagnetic impurities on the surface. In cement pastes, however, it seems reasonable to attribute surface relaxation to dipole interactions in water adsorbed as water of hydration on grain surfaces. The rate limiting factor ...
journal_title:Magnetic resonance imaging
pub_type: 杂志文章
doi:10.1016/0730-725x(94)91517-2
更新日期:1994-01-01 00:00:00
abstract:PURPOSE:Although functional magnetic resonance imaging (fMRI) has revealed that spinal cord injury (SCI) causes anomalous changes in task-induced brain activation, its effect during the resting state remains unclear. The aim of this study is to explore the changes of the brain resting-state function in non-human primat...
journal_title:Magnetic resonance imaging
pub_type: 杂志文章
doi:10.1016/j.mri.2014.02.001
更新日期:2014-06-01 00:00:00
abstract::The presence of metallic compounds in facial cosmetics and permanent tattoos may affect the quality of magnetic resonance imaging. We report a case study describing a signal artifact due to the use of a leave-on powdered hair dye. On reviewing the ingredients of the product, it was found to contain several metallic co...
journal_title:Magnetic resonance imaging
pub_type: 杂志文章
doi:10.1016/j.mri.2016.08.023
更新日期:2017-01-01 00:00:00
abstract:OBJECTIVE:This study aims to evaluate the applicability of using single-shot and multi-shot segmented diffusion-weighted imaging (DWI) techniques to support biopsy target localization in a cohort of targeted MRI-guided prostate biopsy patients. MATERIALS AND METHODS:Single-shot echo-planar diffusion-weighted imaging (...
journal_title:Magnetic resonance imaging
pub_type: 杂志文章
doi:10.1016/j.mri.2016.05.012
更新日期:2016-10-01 00:00:00
abstract::The applicability of the synthetic manganese porphyrin MnTPPS as tumor-selective MRI-contrast agent for brain tumors was investigated quantitatively by in vivo relaxometry. To exclude toxic effects of side products, the purification method for MnTPPS was improved. As a result, MnTPPS+Cl- (free acid) with a purity of m...
journal_title:Magnetic resonance imaging
pub_type: 杂志文章
doi:10.1016/0730-725x(93)90007-z
更新日期:1993-01-01 00:00:00
abstract::The goal of this study was to determine whether presurgical metabolite levels measured by 3D MR Spectroscopic Imaging (MRSI) can accurately detect viable cancer within human brain tumor masses. A total of 31 patients (33 exams, 39 pathology correlations) with brain tumors were studied prior to surgical biopsy and/or r...
journal_title:Magnetic resonance imaging
pub_type: 临床试验,杂志文章
doi:10.1016/s0730-725x(01)00225-9
更新日期:2001-01-01 00:00:00
abstract::Signal fluctuations in functional magnetic resonance imaging (fMRI) can result from a number of sources that may have a neuronal, physiologic or instrumental origin. To determine the relative contribution of these sources, we recorded physiological (respiration and cardiac) signals simultaneously with fMRI in human vo...
journal_title:Magnetic resonance imaging
pub_type: 杂志文章
doi:10.1016/j.mri.2009.02.004
更新日期:2009-10-01 00:00:00
abstract::The objective of this study was to analyze regional variations of magnetic resonance (MR) relaxation times (T1ρ and T2) in hip joint cartilage of healthy volunteers and subjects with femoral acetabular impingement (FAI). Morphological and quantitative images of the hip joints of 12 healthy volunteers and 9 FAI patient...
journal_title:Magnetic resonance imaging
pub_type: 杂志文章
doi:10.1016/j.mri.2013.01.009
更新日期:2013-09-01 00:00:00
abstract::We determined whether the accuracy of magnetic resonance angiography (MRA) in the peripheral run-off vessels can be improved by using contrast-enhanced (CE) three-dimensional (3D) technique in comparison to electrocardiograph (ECG)-triggered two-dimensional (2D) time-of-flight (TOF) technique. In a prospective study 2...
journal_title:Magnetic resonance imaging
pub_type: 杂志文章
doi:10.1016/s0730-725x(98)00078-2
更新日期:1998-10-01 00:00:00
abstract::Magnetic resonance imaging (MRI) and spectroscopy (MRS) have contributed considerably to clinical radiology, and a variety of MR techniques have been developed to evaluate pathological processes as well as normal tissue biology at the cellular and molecular level. However, in comparison to nuclear imaging, MRI has rel...
journal_title:Magnetic resonance imaging
pub_type: 杂志文章
doi:10.1016/j.mri.2016.12.008
更新日期:2017-05-01 00:00:00
abstract::We report the first application of a novel diffusion-based MRI method, called diffusional kurtosis imaging (DKI), to investigate changes in brain tissue microstructure in patients with mild cognitive impairment (MCI) and AD and in cognitively intact controls. The subject groups were characterized and compared in terms...
journal_title:Magnetic resonance imaging
pub_type: 杂志文章
doi:10.1016/j.mri.2013.02.008
更新日期:2013-07-01 00:00:00
abstract::The purpose of this study is to illustrate motion correction in Musculoskeletal (MSK) Magnetic Resonance Imaging (MRI) through utilization of information from an optical tracker to capture the extent and instant of motion. A Digital Single Lens Reflexive camera is employed as the optical tracker to capture the extent ...
journal_title:Magnetic resonance imaging
pub_type: 杂志文章
doi:10.1016/j.mri.2017.12.031
更新日期:2018-05-01 00:00:00
abstract::Brain alcohol was measured in rhesus monkeys (Macaca mulatta) by proton magnetic resonance spectroscopy (MRS) following acute nasogastric alcohol administration (0.8 g/kg). Monkeys were anesthetized with ketamine and xylazine. A 1.5 T whole body imager and a 3-inch surface coil were used to acquire TE 30 and 270 ms sp...
journal_title:Magnetic resonance imaging
pub_type: 杂志文章
doi:10.1016/0730-725x(94)90089-a
更新日期:1994-01-01 00:00:00
abstract:OBJECT:Quantitative T2 measurement is applied in cardiac Magnetic Resonance Imaging (MRI) for the diagnosis and follow-up of myocardial pathologies. Standard Electrocardiogram (ECG)-gated fast spin echo pulse sequences can be used clinically for T2 assessment, with multiple breath-holds. However, heart rate is subject ...
journal_title:Magnetic resonance imaging
pub_type: 杂志文章
doi:10.1016/j.mri.2013.06.006
更新日期:2013-11-01 00:00:00
abstract::A dextran-Gd-DTPA compound has been recently synthesized utilizing 70,800 Da molecular weight dextran. This polymeric contrast agent for magnetic resonance imaging has been found chemically to be very stable and to demonstrate in vitro improved relaxivities of 1.5 to 2.3 times that of monomeric Gd-DTPA at 100 MHz. Thi...
journal_title:Magnetic resonance imaging
pub_type: 杂志文章
doi:10.1016/0730-725x(92)90515-2
更新日期:1992-01-01 00:00:00
abstract::The mapping of the human brain white matter fiber networks relative to deep subcortical and cortical gray matter requires high spatial resolution which is challenged by the low signal-to-noise ratio. The purpose of this short report was to introduce a whole brain high spatial resolution diffusion tensor imaging (DTI) ...
journal_title:Magnetic resonance imaging
pub_type: 杂志文章
doi:10.1016/j.mri.2008.10.007
更新日期:2009-06-01 00:00:00
abstract::The quantitative determination of flow velocities using inflow-outflow techniques require slice selective excitation pulses. The intensity-velocity relationship for such methods is shown to be such that flow velocities estimated using techniques which rely on an absolute calibration of the measured intensity are sensi...
journal_title:Magnetic resonance imaging
pub_type: 杂志文章
doi:10.1016/0730-725x(89)90325-1
更新日期:1989-01-01 00:00:00