Abstract：
:The current fMRI study investigated correlations of low-frequency signal changes in the left inferior frontal gyrus, right inferior frontal gyrus and cerebellum in 13 adult dyslexic and 10 normal readers to examine functional networks associated with these regions. The extent of these networks to regions associated with phonological processing (frontal gyrus, occipital gyrus, angular gyrus, inferior temporal gyrus, fusiform gyrus, supramarginal gyrus and cerebellum) was compared between good and dyslexic readers. Analysis of correlations in low-frequency range showed that regions known to activate during an "on-off" phoneme-mapping task exhibit synchronous signal changes when the task is administered continuously (without any "off" periods). Results showed that three functional networks, which were defined on the basis of documented structural deficits in dyslexics and included regions associated with phonological processing, differed significantly in spatial extent between good readers and dyslexics. The methodological, theoretical and clinical significance of the findings for advancing fMRI research and knowledge of dyslexia are discussed.
journal_name
Magn Reson Imagingjournal_title
Magnetic resonance imagingauthors
Stanberry LI,Richards TL,Berninger VW,Nandy RR,Aylward EH,Maravilla KR,Stock PS,Cordes Ddoi
10.1016/j.mri.2005.12.006subject
Has Abstractpub_date
2006-04-01 00:00:00pages
217-29issue
3eissn
0730-725Xissn
1873-5894pii
S0730-725X(05)00372-3journal_volume
24pub_type
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