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The use of Gd-DOTA in magnetic resonance imaging of experimentally induced mammary tumors.

Abstract：

:Gd-DOTA contrast enhancement of MR images was evaluated on induced mammary tumors in female rats. A single intravenous injection of the carcinogenic N-nitrosourea ENU was administered to Wistar rats; this simple treatment led to a high percentage of mammary tumors without causing death. All the induced tumors were adenocarcinoma and their heterogeneousness depended on their size. The induced tumors did not have intra- or extravascular inflammatory spaces caused by heterotopic lesions, as is the case with implanted tumors. Before injection of Gd-DOTA, appearance of the patchy internal structure was clearly demonstrated on spin-echo images performed with long repetition times. Three doses of the paramagnetic contrast agent (0.1, 0.2, and 0.5 mmol/kg) were evaluated on two different T1-weighted MR sequences. Images were recorded before and repeatedly after intravenous injection of Gd-DOTA, and signal intensities and relaxation times were measured. On images acquired with the spin-echo 500/28 as well as the inversion-recovery 928/26/300 sequences, the results showed that 0.2 mmol/kg Gd-DOTA was the optimal dose for contrast enhancement and for clear visualization of the heterogeneousness of the mammary tumor.

journal_name

Magn Reson Imaging

journal_title

Magnetic resonance imaging

authors

Bonnet PA,Michel A,Fernandez JP,Cyteval C,Rifai A,Boucard M,Chapat JP,Lamarque JL

doi

10.1016/0730-725x(90)90215-n

subject

Has Abstract

pub_date

1990-01-01 00:00:00

pages

71-7

issue

1

eissn

0730-725X

issn

1873-5894

pii

0730-725X(90)90215-N

journal_volume

8

pub_type

杂志文章

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