Abstract:
:The hippocampal formation is a brain system that is implicated in learning and memory. The major input to the hippocampus arrives from the entorhinal cortex (EC) to the dentate gyrus (DG) through the perforant path. In the present work, we have investigated the functional properties of this connection by concomitantly applying electrophysiological techniques, deep-brain electric microstimulation and functional magnetic resonance imaging in anesthetized rats. We systematically delivered different current intensities at diverse stimulation frequencies to the perforant path while recording electrophysiological and blood-oxygenation-level-dependent (BOLD) signals. We observed a linear relationship between the current intensity used to stimulate the hippocampal formation and the amplitude and extension of the induced BOLD response. In addition, we found a frequency-dependent spatial pattern of activation. With stimulation protocols and train frequencies used for kindling, the activity strongly spreads ipsilaterally through the hippocampus, DG, subiculum and EC.
journal_name
Magn Reson Imagingjournal_title
Magnetic resonance imagingauthors
Canals S,Beyerlein M,Murayama Y,Logothetis NKdoi
10.1016/j.mri.2008.02.018subject
Has Abstractpub_date
2008-09-01 00:00:00pages
978-86issue
7eissn
0730-725Xissn
1873-5894pii
S0730-725X(08)00102-1journal_volume
26pub_type
杂志文章abstract:INTRODUCTION:Pharmacokinetic parameters derived from dynamic contrast-enhanced MRI (DCE-MRI) data are sensitive to acquisition and post-processing techniques, which makes it difficult to compare results obtained using different methods. In particular, one of the most important factors affecting estimation of model para...
journal_title:Magnetic resonance imaging
pub_type: 杂志文章
doi:10.1016/j.mri.2018.05.007
更新日期:2018-10-01 00:00:00
abstract::Etched particle tracks produced after heavy ion irradiation of polymer foils are used as model systems to test the performance of NMR in a newly developed ultrahigh magnetic field gradient system. The stimulated NMR echo decay of molecules diffusing in the channels, formulated in terms of the self part of the intermed...
journal_title:Magnetic resonance imaging
pub_type: 杂志文章
doi:10.1016/0730-725x(94)91527-x
更新日期:1994-01-01 00:00:00
abstract::Use of conjugated equine estrogens (CEE) has been linked to smaller regional brain volumes in women aged ≥65 years; however, it is unknown whether this results in a broad-based characteristic pattern of effects. Structural magnetic resonance imaging was used to assess regional volumes of normal tissue and ischemic les...
journal_title:Magnetic resonance imaging
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.mri.2010.12.001
更新日期:2011-05-01 00:00:00
abstract::The goal of this study was to develop and evaluate high-resolution magnetic resonance spectroscopic imaging (MRSI) utilizing the gains in signal-to-noise ratio (SNR) provided by combining higher magnetic field with high-sensitivity phased-array (PA) coils. We investigated the maximum improvement in spatial resolution ...
journal_title:Magnetic resonance imaging
pub_type: 杂志文章
doi:10.1016/j.mri.2005.10.019
更新日期:2006-01-01 00:00:00
abstract::T2-weighted images are considered the most sensitive for lesion detection at high field; however, long imaging time is problematic. Accordingly, the authors compared four breath-hold T2 or T2* weighted sequences comprising T2*-weighted FLASH, T2*-weighted PSIF, T2-weighted rapid spin echo (RASE), and T2-weighted Turbo...
journal_title:Magnetic resonance imaging
pub_type: 杂志文章
doi:10.1016/0730-725x(92)90371-6
更新日期:1992-01-01 00:00:00
abstract::Magnetic resonance imaging (MRI) has been used to characterize tissues in morphological studies. Here, 23Na NMR imaging was used to study the distribution in muscle of brine (5 M NaCl), injected before onset of rigor mortis. First, the distribution of brine was monitored in excised muscle from rabbits for 6 hr followi...
journal_title:Magnetic resonance imaging
pub_type: 杂志文章
doi:10.1016/0730-725x(94)92360-4
更新日期:1994-01-01 00:00:00
abstract::NMR imaging and localized 1H spectroscopy of a variety of aquatic organisms in vivo is described for the first time. The practical consideration of life support, water volume, salinity, and anesthesia are discussed and solutions presented. Such animal studies shape our understanding of physiology, biochemistry, and bi...
journal_title:Magnetic resonance imaging
pub_type: 杂志文章
doi:10.1016/0730-725x(90)90253-x
更新日期:1990-01-01 00:00:00
abstract::One of the most critical structural parameters in elastomeric materials is the density of cross-linking between the polymeric chains. This chemical feature greatly affects chain motions and is determinant in controlling mechanical properties of the final product. NMR techniques are widely and efficiently applied to in...
journal_title:Magnetic resonance imaging
pub_type: 杂志文章
doi:10.1016/s0730-725x(01)00257-0
更新日期:2001-04-01 00:00:00
abstract:OBJECT:Virtual Phantom Magnetic Resonance Imaging (ViP MRI) is a method to generate reference signals on MR images, using external radiofrequency (RF) signals. The aim of this study was to assess the feasibility of ViP MRI to generate complex-data images of phantoms mimicking water-fat systems. MATERIALS AND METHODS:V...
journal_title:Magnetic resonance imaging
pub_type: 杂志文章
doi:10.1016/j.mri.2015.12.002
更新日期:2016-06-01 00:00:00
abstract::We report the MR appearance of undifferentiated (embryonal) sarcoma of the liver (USL) in a 13-year-old female who presented with a 1-year history of intermittent abdominal pain, weight loss, and fatigue. The tumor was a large, solitary, well-defined focal mass lesion with multiple cystic spaces, septations, and subst...
journal_title:Magnetic resonance imaging
pub_type: 杂志文章
doi:10.1016/j.mri.2004.02.003
更新日期:2004-07-01 00:00:00
abstract::In pharmacological magnetic resonance imaging (phMRI) with anesthetized animals, there is usually only a single time window to observe the dynamic signal change to an acute drug administration since subsequent drug injections are likely to result in altered response properties (e.g., tolerance). Unlike the block-desig...
journal_title:Magnetic resonance imaging
pub_type: 杂志文章
doi:10.1016/j.mri.2008.02.020
更新日期:2008-11-01 00:00:00
abstract::A model of MRI signal intensity which is a function of perfusion is developed based upon the assumption that biological tissue can be represented by a blood and tissue compartment. The longitudinal magnetization is derived from the Bloch equations which are modified to model the magnetization in both the blood and tis...
journal_title:Magnetic resonance imaging
pub_type: 杂志文章
doi:10.1016/0730-725x(91)90095-4
更新日期:1991-01-01 00:00:00
abstract::Liver fibrosis determines the functional liver reserve. Several studies have reported that the apparent diffusion coefficient (ADC) values of diffusion-weighted magnetic resonance imaging (DW-MRI) can assess liver fibrosis. We investigated whether DW-MRI predicts postoperative hepatic insufficiency and liver fibrosis ...
journal_title:Magnetic resonance imaging
pub_type: 杂志文章
doi:10.1016/j.mri.2010.03.018
更新日期:2010-07-01 00:00:00
abstract::We examined if MR diffusion tensor imaging with fiber tracking could be performed on the sciatic nerve. In 3 healthy volunteers the proximal thigh was examined on a 1.5-Tesla MR-scanner with a 2-channel phased-array coil. Though inherently susceptible to motion, field inhomogeneities, and fast T(2)-relaxation of the d...
journal_title:Magnetic resonance imaging
pub_type: 杂志文章
doi:10.1016/j.mri.2004.01.073
更新日期:2004-06-01 00:00:00
abstract::MRI reconstruction using super-resolution is presented and shown to improve spatial resolution in cases when spatially-selective RF pulses are used for localization. In 2-D multislice MRI, the resolution in the slice direction is often lower than the in-plane resolution. For certain diagnostic imaging applications, is...
journal_title:Magnetic resonance imaging
pub_type: 杂志文章
doi:10.1016/s0730-725x(02)00511-8
更新日期:2002-06-01 00:00:00
abstract::Poly(L-glutamic acid) (PGA)-cystamine-[gadolinium (Gd)-DO3A] was prepared in high yield with a high Gd-DO3A conjugation efficiency. Approximately 55% of the carboxylic groups in PGA were loaded with Gd-DO3A via cystamine as the spacer. Cystamine can be readily cleaved by endogenous thiols to release the Gd(III) chelat...
journal_title:Magnetic resonance imaging
pub_type: 杂志文章
doi:10.1016/j.mri.2006.03.009
更新日期:2006-09-01 00:00:00
abstract::Dysfunction of the corticolimbic circuitry has been highlighted in social anxiety disorder (SAD) during social stimuli. However, few studies have investigated functional connectivity in SAD during the resting state, which may improve our understanding of SAD pathophysiology. The aim of this study was to investigate wh...
journal_title:Magnetic resonance imaging
pub_type: 杂志文章
doi:10.1016/j.mri.2011.02.013
更新日期:2011-06-01 00:00:00
abstract::Susceptibility differences are common causes for artifacts in magnetic resonance (MR); therefore, it is important to choose phantom materials in a way that these artifacts are kept at a minimum. In this study, a previously proposed MR imaging (MRI) method [Beuf O, Briguet A, Lissac M, Davis R. Magnetic resonance imagi...
journal_title:Magnetic resonance imaging
pub_type: 杂志文章
doi:10.1016/j.mri.2006.07.005
更新日期:2006-11-01 00:00:00
abstract::Multi-echo pulse sequences for producing T2-weighted images in much reduced imaging times have recently been developed for routine clinical use. A number of recent articles have described the contrast obtained with fast spin-echo (FSE) sequences and have generally indicated that they depict tissues very similarly to c...
journal_title:Magnetic resonance imaging
pub_type: 杂志文章,评审
doi:10.1016/0730-725x(92)90001-g
更新日期:1992-01-01 00:00:00
abstract::A magnetic resonance imaging (MRI) method is described that allows interleaved measurements of transverse (R(2)(*) and R(2)) and longitudinal (R(1)) relaxation rates of tissue water in conjunction with spin labeling. The image-contrasts are intrinsically blood oxygenation level dependent (BOLD) and cerebral blood flow...
journal_title:Magnetic resonance imaging
pub_type: 杂志文章
doi:10.1016/s0730-725x(00)00125-9
更新日期:2000-04-01 00:00:00
abstract::Echo planar imaging (EPI) was extended for the acquisition of both, the spin-echo (SE) and the stimulated echo in a stimulated echo sequence after one excitation from thermal equilibrium. The two independent EPI images reflect different states of the transverse magnetization excited and measured almost simultaneously....
journal_title:Magnetic resonance imaging
pub_type: 杂志文章
doi:10.1016/0730-725x(94)91234-n
更新日期:1994-01-01 00:00:00
abstract::The objective of this study was to describe magnetic resonance (MR) findings with a 1.5T imager for hepatic parenchymal changes after proton beam radiotherapy. Thirty-two patients who received proton radiotherapy with doses of 50-87 Gy underwent MR imaging 1-75 months (mean 22 months) after the start of irradiation. A...
journal_title:Magnetic resonance imaging
pub_type: 杂志文章
doi:10.1016/s0730-725x(00)00152-1
更新日期:2000-07-01 00:00:00
abstract:PURPOSE:To develop a free-running framework for 3D isotropic simultaneous myocardial T1/T2 mapping and cine imaging. METHODS:Continuous data acquisition with 3D golden angle radial trajectory is used in conjunction with T2 preparation of varying echo times and inversion recovery (IR) pulses to enable simultaneous myoc...
journal_title:Magnetic resonance imaging
pub_type: 杂志文章
doi:10.1016/j.mri.2019.08.008
更新日期:2019-11-01 00:00:00
abstract::Due to the presence of artifacts induced by fast-imaging acquisition in functional magnetic resonance imaging (fMRI) studies, it is very difficult to estimate the variance of thermal noise by traditional methods in magnitude images. Moreover, the existence of incidental phase fluctuations impairs the validity of curre...
journal_title:Magnetic resonance imaging
pub_type: 杂志文章
doi:10.1016/j.mri.2006.12.007
更新日期:2007-09-01 00:00:00
abstract::Several previous 31 phosphorus magnetic resonance spectroscopy ((31)P MRS) studies performing incremental or progressive muscle exercises have observed that a decrease in pH is accompanied with an acceleration in phosphocreatine (PCr) hydrolysis. The purpose of this study was to investigate the relationship between PC...
journal_title:Magnetic resonance imaging
pub_type: 杂志文章
doi:10.1016/j.mri.2003.07.001
更新日期:2004-01-01 00:00:00
abstract::We report the first application of a novel diffusion-based MRI method, called diffusional kurtosis imaging (DKI), to investigate changes in brain tissue microstructure in patients with mild cognitive impairment (MCI) and AD and in cognitively intact controls. The subject groups were characterized and compared in terms...
journal_title:Magnetic resonance imaging
pub_type: 杂志文章
doi:10.1016/j.mri.2013.02.008
更新日期:2013-07-01 00:00:00
abstract::The NMR relaxivities of Gd-EOB-DTPA and Gd-DTPA were determined in the kidney and liver of intact male Wistar rats immediately following sacrifice and in vitro in solutions and gels, at 1.5 T using a clinical MR scanner, T1 and T2 values of tissue samples were derived from spin-echo image sequences. Tissue gadolinium ...
journal_title:Magnetic resonance imaging
pub_type: 杂志文章
doi:10.1016/0730-725x(95)02097-d
更新日期:1996-01-01 00:00:00
abstract::Twenty-seven patients with soft-tissue tumors were examined with a Picker 0.15-tesla resistive magnet and by computed tomography (CT). In all but one patient, MRI was better than or equal to CT in defining the anatomic extent of the tumor. We could determine whether major vascular structures were engulfed by the tumor...
journal_title:Magnetic resonance imaging
pub_type: 杂志文章
doi:10.1016/0730-725x(85)90398-4
更新日期:1985-01-01 00:00:00
abstract::In porous material research, one main interest of nuclear magnetic resonance diffusion (NMR) experiments is the determination of the shape of pores. While it has been a longstanding question if this is in principle achievable, it has been shown recently that it is indeed possible to perform NMR-based diffusion pore im...
journal_title:Magnetic resonance imaging
pub_type: 杂志文章
doi:10.1016/j.mri.2013.03.027
更新日期:2013-09-01 00:00:00
abstract:INTRODUCTION:Recent animal and human epidemiological studies suggest that early childhood exposure to anesthesia may have adverse effects on brain development. As more than 50% of pregnant women in the United States and one-third in the United Kingdom receive regional anesthesia during labor and delivery, understanding...
journal_title:Magnetic resonance imaging
pub_type: 杂志文章
doi:10.1016/j.mri.2014.08.033
更新日期:2015-02-01 00:00:00