Electric stimulation fMRI of the perforant pathway to the rat hippocampus.

Abstract:

:The hippocampal formation is a brain system that is implicated in learning and memory. The major input to the hippocampus arrives from the entorhinal cortex (EC) to the dentate gyrus (DG) through the perforant path. In the present work, we have investigated the functional properties of this connection by concomitantly applying electrophysiological techniques, deep-brain electric microstimulation and functional magnetic resonance imaging in anesthetized rats. We systematically delivered different current intensities at diverse stimulation frequencies to the perforant path while recording electrophysiological and blood-oxygenation-level-dependent (BOLD) signals. We observed a linear relationship between the current intensity used to stimulate the hippocampal formation and the amplitude and extension of the induced BOLD response. In addition, we found a frequency-dependent spatial pattern of activation. With stimulation protocols and train frequencies used for kindling, the activity strongly spreads ipsilaterally through the hippocampus, DG, subiculum and EC.

journal_name

Magn Reson Imaging

authors

Canals S,Beyerlein M,Murayama Y,Logothetis NK

doi

10.1016/j.mri.2008.02.018

subject

Has Abstract

pub_date

2008-09-01 00:00:00

pages

978-86

issue

7

eissn

0730-725X

issn

1873-5894

pii

S0730-725X(08)00102-1

journal_volume

26

pub_type

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