Abstract:
:We have synthesized a surface functionalized superparamagnetic iron oxide colloid whose clearance from the vascular compartment was inhibited by asialofetuin but not fetuin. Unlike other particulate or colloidal magnetic resonance (MR) contrast agents, the agent of the current communication is not withdrawn from the vascular compartment by cells of the macrophage-monocyte phagocytic system, as indicated by its selective increase in hepatic relaxation rates. Because of this we refer to this colloid as a hepatic selective (HS) MR contrast agent. At 20 mumol Fe/kg the HS MR agent darkened MR images of liver. The HS MR agent exhibited no acute toxicity when injected into rats at 1800 mumol Fe/kg. Based on these observations, surface functionalized superparamagnetic iron oxide colloids may be the basis of MR contrast agents internalized by receptor mediated endocytosis generally, and by the asialoglycoprotein receptor in particular.
journal_name
Magn Reson Imagingjournal_title
Magnetic resonance imagingauthors
Josephson L,Groman EV,Menz E,Lewis JM,Bengele Hdoi
10.1016/0730-725x(90)90143-psubject
Has Abstractpub_date
1990-01-01 00:00:00pages
637-46issue
5eissn
0730-725Xissn
1873-5894pii
0730-725X(90)90143-Pjournal_volume
8pub_type
杂志文章abstract::We studied the effect of hydralazine on tumor blood volume fraction and microvascular random flow velocity magnitude by IVIM weighted MRI in conjunction with dynamic Gd-DTPA-Albumin enhanced MRI. Blood volume fraction maps were obtained from the dynamic Gd-DTPA-Albumin enhanced MRI measurements. The average blood volu...
journal_title:Magnetic resonance imaging
pub_type: 杂志文章
doi:10.1016/s0730-725x(01)00431-3
更新日期:2001-10-01 00:00:00
abstract:OBJECTIVE:The purpose of this study was to analyze flow patterns in the pulmonary circulation of healthy volunteers by using 4D flow magnetic resonance imaging. MATERIALS AND METHODS:The study was approved by the local ethics committee and all subjects gave written informed consent. Eighteen volunteers underwent a 4D ...
journal_title:Magnetic resonance imaging
pub_type: 杂志文章
doi:10.1016/j.mri.2012.06.036
更新日期:2013-02-01 00:00:00
abstract::White matter loss, ventricular enlargement and white matter lesions are common findings on brain scans of older subjects. Accurate assessment of these different features is therefore essential for normal aging research. Recently, we developed a novel unsupervised classification method, named 'Multispectral Coloring Mo...
journal_title:Magnetic resonance imaging
pub_type: 杂志文章
doi:10.1016/j.mri.2011.09.016
更新日期:2012-02-01 00:00:00
abstract::Our purpose was to investigate three-dimensional (3D) gadolinium-enhanced magnetic resonance angiography (Gd-MRA) in the evaluation of renal transplant arteries. Eleven MR angiography examinations were performed in nine renal transplant patients. Gd-MRA, three-dimensional phase contrast (3D-PC) post-gadolinium, and tw...
journal_title:Magnetic resonance imaging
pub_type: 杂志文章
doi:10.1016/s0730-725x(96)00348-7
更新日期:1997-01-01 00:00:00
abstract::The site-dependent variations in trabecular bone morphology were studied in the rat tibia by magnitude and phase difference three-dimensional nuclear magnetic resonance microscopy and image processing, and the implications of ovariectomy were evaluated. Specimens excised from the proximal tibial metaphysis in ovariect...
journal_title:Magnetic resonance imaging
pub_type: 杂志文章
doi:10.1016/s0730-725x(99)00107-1
更新日期:2000-01-01 00:00:00
abstract::Disseminated osseous tuberculosis is a rare disease. This is a report of two cases of disseminated osseous tuberculosis imaged with MRI at 1.5-T, CT, plain radiography and bone scintigraphy. CT and plain radiography demonstrated either highly destructive or cystic lesions with sclerotic margins. Bone scintigraphy and ...
journal_title:Magnetic resonance imaging
pub_type: 杂志文章
doi:10.1016/0730-725x(87)90384-5
更新日期:1987-01-01 00:00:00
abstract::The non-Einstein diffusion behavior of water in a model biological tissue system, intact duck embryos, has been investigated by the use of an in vivo proton pulsed-gradient spin-echo (PGSE) MR imaging technique. Multiple-frame MR images of the intact duck embryos and control solution (0.5 mM CuSO4 doped water) were ac...
journal_title:Magnetic resonance imaging
pub_type: 杂志文章
doi:10.1016/0730-725x(93)90476-t
更新日期:1993-01-01 00:00:00
abstract::In-plane flow quantification in MRI offers the potential for assessing vessel patency, and both volume flow rate and flow velocity. These techniques will have definite future impact on MR angiography. The method used in this paper employs motion artifact suppression technique (MAST) gradients to refocus spins travelli...
journal_title:Magnetic resonance imaging
pub_type: 杂志文章
doi:10.1016/0730-725x(88)90409-2
更新日期:1988-05-01 00:00:00
abstract::Arterial spin labeling (ASL) perfusion fMRI data differ in important respects from the more familiar blood oxygen level-dependent (BOLD) fMRI data and require specific processing strategies. In this paper, we examined several factors that may influence ASL data analysis, including data storage bit resolution, motion c...
journal_title:Magnetic resonance imaging
pub_type: 杂志文章
doi:10.1016/j.mri.2007.07.003
更新日期:2008-02-01 00:00:00
abstract::Super paramagnetic iron oxide Fe(3)O(4) nanoparticles prepared via photochemical reaction in pure form were used for inducing hyperthermia to treat subcutaneous Ehrlich carcinoma implanted in female mice. Our results indicate that the mean temperature profiles at the rectum, periphery of the tumor surface and at the c...
journal_title:Magnetic resonance imaging
pub_type: 杂志文章
doi:10.1016/j.mri.2010.08.010
更新日期:2011-02-01 00:00:00
abstract:PURPOSE:Intramuscular fat infiltration is a dynamic process, in response to exercise and muscle health, which can be quantified by estimating fat fraction (FF) from Dixon MRI. Healthy hip abductor muscles are a good indicator of a healthy hip and an active lifestyle as they have a fundamental role in walking. The autom...
journal_title:Magnetic resonance imaging
pub_type: 杂志文章
doi:10.1016/j.mri.2020.06.019
更新日期:2020-10-01 00:00:00
abstract::Truncation artifacts arise in magnetic resonance spectroscopic imaging (MRSI) of the human brain due to limited coverage of k-space necessitated by low SNR of metabolite signal and limited scanning time. In proton MRSI of the head, intense extra-cranial lipid signals "bleed" into brain regions, thereby contaminating s...
journal_title:Magnetic resonance imaging
pub_type: 杂志文章
doi:10.1016/s0730-725x(02)00608-2
更新日期:2002-12-01 00:00:00
abstract::In pharmacological magnetic resonance imaging (phMRI) with anesthetized animals, there is usually only a single time window to observe the dynamic signal change to an acute drug administration since subsequent drug injections are likely to result in altered response properties (e.g., tolerance). Unlike the block-desig...
journal_title:Magnetic resonance imaging
pub_type: 杂志文章
doi:10.1016/j.mri.2008.02.020
更新日期:2008-11-01 00:00:00
abstract:PURPOSE:Rapid regional fluctuations in GABA may result in inhomogeneous concentrations throughout the brain parenchyma. The goal of this study is to provide further insight into the natural distribution of GABA throughout the brain and thus determine if a surrogate site may be used for spectroscopy when evaluating moto...
journal_title:Magnetic resonance imaging
pub_type: 杂志文章
doi:10.1016/j.mri.2015.02.015
更新日期:2015-06-01 00:00:00
abstract::We determined whether the accuracy of magnetic resonance angiography (MRA) in the peripheral run-off vessels can be improved by using contrast-enhanced (CE) three-dimensional (3D) technique in comparison to electrocardiograph (ECG)-triggered two-dimensional (2D) time-of-flight (TOF) technique. In a prospective study 2...
journal_title:Magnetic resonance imaging
pub_type: 杂志文章
doi:10.1016/s0730-725x(98)00078-2
更新日期:1998-10-01 00:00:00
abstract::Brain asymmetry is a phenomenon well known for handedness and has been studied in motor cortices. However, few quantitative studies on asymmetrical cortical activity in motor areas have been conducted. In this study, we systematically investigated asymmetrical cortical activity in motor areas during sequential finger ...
journal_title:Magnetic resonance imaging
pub_type: 杂志文章
doi:10.1016/j.mri.2007.03.024
更新日期:2007-12-01 00:00:00
abstract::Focal brain ischemia was induced by middle cerebral artery occlusion in the rat. The volume of cerebral damage was determined 2 days later by MRI in vivo and in the same animals histologically. The edema volume as measured by MRI and the histologically determined infarction was highly correlated. As a consequence, the...
journal_title:Magnetic resonance imaging
pub_type: 杂志文章
doi:10.1016/0730-725x(92)90411-r
更新日期:1992-01-01 00:00:00
abstract::Balanced steady-state free precession (SSFP) sequences use fully re-focussed gradient waveforms to achieve a high signal and useful image contrast in short scan times. Despite these strengths, the clinical feasibility of balanced SSFP is still limited both by bright fat signal and by the signal voids that result from ...
journal_title:Magnetic resonance imaging
pub_type: 杂志文章
doi:10.1016/j.mri.2005.10.013
更新日期:2006-02-01 00:00:00
abstract:OBJECT:Quantitative T2 measurement is applied in cardiac Magnetic Resonance Imaging (MRI) for the diagnosis and follow-up of myocardial pathologies. Standard Electrocardiogram (ECG)-gated fast spin echo pulse sequences can be used clinically for T2 assessment, with multiple breath-holds. However, heart rate is subject ...
journal_title:Magnetic resonance imaging
pub_type: 杂志文章
doi:10.1016/j.mri.2013.06.006
更新日期:2013-11-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Diffusion MRI characteristics have been used as biomarkers to guide prognosis in cerebral pathologies including brain metastases. The measurement of ADC is often described poorly in clinical and research studies with little detail given to the practical considerations of where to place ROIs, whic...
journal_title:Magnetic resonance imaging
pub_type: 杂志文章
doi:10.1016/j.mri.2013.12.010
更新日期:2014-04-01 00:00:00
abstract::There is increasing interest in imaging short T2 species which show little or no signal with conventional magnetic resonance (MR) pulse sequences. In this paper, we describe the use of three-dimensional ultrashort echo time (3D UTE) sequences with TEs down to 8 μs for imaging of these species. Image contrast was gener...
journal_title:Magnetic resonance imaging
pub_type: 杂志文章
doi:10.1016/j.mri.2010.11.003
更新日期:2011-05-01 00:00:00
abstract::We assessed the magnetic resonance (MR) imaging characteristics of two categories of epileptogenic substrates, neoplasms, and vascular malformations, to determine MR sensitivity and typical imaging features. A blinded retrospective analysis was performed on MR scans from 41 patients who had a neoplasm or vascular malf...
journal_title:Magnetic resonance imaging
pub_type: 杂志文章
doi:10.1016/0730-725x(95)02026-p
更新日期:1995-01-01 00:00:00
abstract::The advantages of the application of NMR imaging to the studies of enhanced oil recovery methods that include polymer slug flooding, combination slug flooding, and thermal soaking are described. ...
journal_title:Magnetic resonance imaging
pub_type: 杂志文章
doi:10.1016/s0730-725x(96)00192-0
更新日期:1996-01-01 00:00:00
abstract::Conditions for generation of polarized RF fields in cylindrical symmetry by high order coils are presented. Whole body NMR transmitters utilizing this principle would require a current control on a certain number of loops. In the present design this is obtained by feeding each loop by an appropriate linear combination...
journal_title:Magnetic resonance imaging
pub_type: 杂志文章
doi:10.1016/0730-725x(88)90398-0
更新日期:1988-05-01 00:00:00
abstract:BACKGROUND:Since the advent of magnetic resonance imaging, metal artifacts have posed an important diagnostic problem in different fields of medicine. However, this has not been systematically studied in patients undergoing surgery for brain tumors. OBJECTIVE:This study was planned to assess whether metal artifacts ca...
journal_title:Magnetic resonance imaging
pub_type: 杂志文章
doi:10.1016/j.mri.2012.11.001
更新日期:2013-06-01 00:00:00
abstract:PURPOSE:To assess the sensitivity and specificity of intra-plaque hemorrhage (IPH), large lipid-rich necrotic core (LR-NC) and ulceration or cap rupture (UCR) for symptomatic carotid plaque characterization and to evaluate a new imaging score [Hemorrhage, Ulceration or cap rupture, Lipid-rich necrotic Core (HULC) score...
journal_title:Magnetic resonance imaging
pub_type: 杂志文章
doi:10.1016/j.mri.2012.04.024
更新日期:2012-12-01 00:00:00
abstract::The ripening of the tomato fruit was delayed for several days (average 5 days) by a 1-day heat treatment at 42 degrees C. Ethylene production increased during the first 3 h, but, after 6 h inhibition was almost total in tomato fruit incubated at 42 degrees C. However, recovery of ethylene production was rapid if fruit...
journal_title:Magnetic resonance imaging
pub_type: 杂志文章
doi:10.1016/s0730-725x(98)00219-7
更新日期:1999-06-01 00:00:00
abstract::To assess whether magnetic resonance imaging could assist in diagnosing Ewing sarcoma, we retrospectively analyzed T1- and T2-weighted images of 24 consecutive solitary lytic bone lesions, including 18 cases of histologically proven Ewing sarcoma, and six aggressive-appearing benign lesions including eosinophilic gran...
journal_title:Magnetic resonance imaging
pub_type: 杂志文章
doi:10.1016/0730-725x(94)92450-3
更新日期:1994-01-01 00:00:00
abstract::Mycotic pseudoaneurysms of the ascending aorta are rare cardiovascular lesions that carry the risk of potentially disastrous complications such as aortic rupture or widespread sepsis. Regardless of its location in the arterial system, this lesion carries a high mortality rate. Early diagnosis of mycotic pseudoaneurysm...
journal_title:Magnetic resonance imaging
pub_type: 杂志文章
doi:10.1016/0730-725x(93)90251-8
更新日期:1993-01-01 00:00:00
abstract:PURPOSE:To develop a method for estimating metabolite concentrations using phased-array coils and sensitivity-encoded (SENSE) magnetic resonance spectroscopic images (MRSI) of the human brain. MATERIALS AND METHODS:The method is based on the phantom replacement technique and uses receive coil sensitivity maps and body...
journal_title:Magnetic resonance imaging
pub_type: 杂志文章
doi:10.1016/j.mri.2009.11.003
更新日期:2010-04-01 00:00:00