当前位置： SCI文献检索 > MAGNETIC RESONANCE IMAGING期刊下所有文献 > Noninvasive evaluation of the regional variations of GABA using magnetic resonance spectroscopy at 3 Tesla.

Noninvasive evaluation of the regional variations of GABA using magnetic resonance spectroscopy at 3 Tesla.

Abstract：

PURPOSE:Rapid regional fluctuations in GABA may result in inhomogeneous concentrations throughout the brain parenchyma. The goal of this study is to provide further insight into the natural distribution of GABA throughout the brain and thus determine if a surrogate site may be used for spectroscopy when evaluating motor diseases, neurological disorders, or psychiatric dysfunction. MATERIALS AND METHODS:In this prospective study, eight healthy volunteers underwent spectroscopic evaluation of the frontal lobe, occipital lobe, lateral temporal lobe, basal ganglia, and both hippocampi using a spin echo variant of a J-difference editing method. Knowledge of the relative peak intensities of the macromolecule peaks at 3ppm and 0.9ppm was used to correct the contribution of co-edited macromolecules to the GABA peak at 3ppm. The GABA values were internally referenced to NAA. Linear regression was used to normalize the effect of regional tissue-fraction variation on the GABA/NAA values. A one-way ANOVA was performed with Tukey's multiple comparison test to compare the normalized GABA/NAA values in each pair of locations. RESULTS:After accounting for the macromolecule contribution to the GABA signal and correction for tissue fraction variation, the normalized GABA/NAA ratios differ significantly between the six brain locations (p<0.001). Pairwise comparisons of the corrected normalized GABA/NAA ratios show statistically significant variation between the frontal lobe and the basal ganglia, frontal and lateral temporal lobes, and frontal lobe and right hippocampus. Variations in the normalized GABA/NAA ratios trend toward significance between the frontal lobe and left hippocampus, occipital lobe and the frontal lobe, occipital lobe and basal ganglia, and occipital lobe and right hippocampus. CONCLUSION:Our study suggests that GABA concentration is inhomogeneous throughout the parenchyma. Studies evaluating the role of GABA must carefully consider voxel placement when incorporating spectroscopy.

journal_name

Magn Reson Imaging

journal_title

Magnetic resonance imaging

authors

Durst CR,Michael N,Tustison NJ,Patrie JT,Raghavan P,Wintermark M,Sendhil Velan S

doi

10.1016/j.mri.2015.02.015

subject

Has Abstract

pub_date

2015-06-01 00:00:00

pages

611-7

issue

5

eissn

0730-725X

issn

1873-5894

pii

S0730-725X(15)00054-5

journal_volume

33

pub_type

杂志文章

相关文献

MAGNETIC RESONANCE IMAGING文献大全
  • Biodegradable cystamine spacer facilitates the clearance of Gd(III) chelates in poly(glutamic acid) Gd-DO3A conjugates for contrast-enhanced MR imaging.

    abstract：:Poly(L-glutamic acid) (PGA)-cystamine-[gadolinium (Gd)-DO3A] was prepared in high yield with a high Gd-DO3A conjugation efficiency. Approximately 55% of the carboxylic groups in PGA were loaded with Gd-DO3A via cystamine as the spacer. Cystamine can be readily cleaved by endogenous thiols to release the Gd(III) chelat...

    journal_title：Magnetic resonance imaging

    pub_type： 杂志文章

    doi：10.1016/j.mri.2006.03.009

    authors： Ke T,Feng Y,Guo J,Parker DL,Lu ZR

    更新日期：2006-09-01 00:00:00

  • Test-retest reliability of cerebral blood flow in healthy individuals using arterial spin labeling: Findings from the EMBARC study.

    abstract：INTRODUCTION:Previous investigations of test-retest reliability of cerebral blood flow (CBF) at rest measured with pseudo-continuous Arterial Spin Labeling (pCASL) demonstrated good reliability, but are limited by the use of similar scanner platforms. In the present study we examined test-retest reliability of CBF in r...

    journal_title：Magnetic resonance imaging

    pub_type： 杂志文章

    doi：10.1016/j.mri.2017.09.004

    authors： Almeida JRC,Greenberg T,Lu H,Chase HW,Fournier JC,Cooper CM,Deckersbach T,Adams P,Carmody T,Fava M,Kurian B,McGrath PJ,McInnis MG,Oquendo MA,Parsey R,Weissman M,Trivedi M,Phillips ML

    更新日期：2018-01-01 00:00:00

  • Simultaneous imaging of locus coeruleus and substantia nigra with a quantitative neuromelanin MRI approach.

    abstract：:Quantitative MRI of neuromelanin (NM) containing structures (referred to as NM-MRI) in the brainstem, namely the locus coeruleus (LC) and substantia nigra (SN), may assist with the early detection of Parkinson's disease (PD) and Alzheimer's disease (AD) as well as differential diagnosis in the early disease stages. In...

    journal_title：Magnetic resonance imaging

    pub_type： 杂志文章

    doi：10.1016/j.mri.2014.07.003

    authors： Chen X,Huddleston DE,Langley J,Ahn S,Barnum CJ,Factor SA,Levey AI,Hu X

    更新日期：2014-12-01 00:00:00

  • MR Imaging of total hip arthroplasty: comparison among sequences to study the sciatic nerve at 1.5 T.

    abstract：PURPOSE:This study was done to test a series of MR sequences for evaluating the sciatic nerve after total hip arthroplasty (THA). MATERIAL AND METHODS:The study protocol was approved by the institutional review board. Informed consent was obtained from all patients. Twenty-five patients (11 men and 14 women mean age: ...

    journal_title：Magnetic resonance imaging

    pub_type： 杂志文章

    doi：10.1016/j.mri.2010.06.009

    authors： Tagliafico A,Podestà A,Assini A,Boccacini L,Serafini G,Calabrese M,Martinoli C

    更新日期：2010-11-01 00:00:00

  • Effects of 3D sampling in (k, t)-space on temporal qualities of dynamic MRI.

    abstract：:3D (kx, ky, t)-space analysis is invoked to provide insights into dynamic magnetic resonance imaging (DMRI) with arbitrary k-space sampling trajectories. The effects of 3D sampling in (kx, ky, t) are analyzed theoretically and verified with computer simulation. The analyses show that a 3D sampling pattern that is more...

    journal_title：Magnetic resonance imaging

    pub_type： 杂志文章

    doi：10.1016/j.mri.2006.04.009

    authors： Park JB,Nishimura DG

    更新日期：2006-10-01 00:00:00

  • A deep learning approach to estimation of subject-level bias and variance in high angular resolution diffusion imaging.

    abstract：:The ability to evaluate empirical diffusion MRI acquisitions for quality and to correct the resulting imaging metrics allows for improved inference and increased replicability. Previous work has shown promise for estimation of bias and variance of generalized fractional anisotropy (GFA) but comes at the price of compu...

    journal_title：Magnetic resonance imaging

    pub_type： 杂志文章

    doi：10.1016/j.mri.2019.03.021

    authors： Hainline AE,Nath V,Parvathaneni P,Schilling KG,Blaber JA,Anderson AW,Kang H,Landman BA

    更新日期：2019-06-01 00:00:00

  • Complimentary aspects of diffusion imaging and fMRI: II. Elucidating contributions to the fMRI signal with diffusion sensitization.

    abstract：:Tissue water molecules reside in different biophysical compartments. For example, water molecules in the vasculature reside for variable periods of time within arteries, arterioles, capillaries, venuoles and veins, and may be within blood cells or blood plasma. Water molecules outside of the vasculature, in the extrav...

    journal_title：Magnetic resonance imaging

    pub_type： 杂志文章,评审

    doi：10.1016/j.mri.2007.02.006

    authors： Mulkern RV,Haker SJ,Maier SE

    更新日期：2007-07-01 00:00:00

  • MRI of polysplenia syndrome.

    abstract：:The polysplenia syndrome is the association of multiple spleens, situs inversus, congenital heart disease, and azygous continuation of the inferior vena cava. Magnetic resonance (MR) is a noninvasive imaging modality which can easily confirm the multiplicity of spleens, situs inversus, and identify complex congenital ...

    journal_title：Magnetic resonance imaging

    pub_type： 杂志文章

    doi：10.1016/0730-725x(89)90538-9

    authors： Jelinek JS,Stuart PL,Done SL,Ghaed N,Rudd SA

    更新日期：1989-11-01 00:00:00

  • The use of Gd-DOTA in magnetic resonance imaging of experimentally induced mammary tumors.

    abstract：:Gd-DOTA contrast enhancement of MR images was evaluated on induced mammary tumors in female rats. A single intravenous injection of the carcinogenic N-nitrosourea ENU was administered to Wistar rats; this simple treatment led to a high percentage of mammary tumors without causing death. All the induced tumors were ade...

    journal_title：Magnetic resonance imaging

    pub_type： 杂志文章

    doi：10.1016/0730-725x(90)90215-n

    authors： Bonnet PA,Michel A,Fernandez JP,Cyteval C,Rifai A,Boucard M,Chapat JP,Lamarque JL

    更新日期：1990-01-01 00:00:00

  • The study of heat stress in tomato fruits by NMR microimaging.

    abstract：:The ripening of the tomato fruit was delayed for several days (average 5 days) by a 1-day heat treatment at 42 degrees C. Ethylene production increased during the first 3 h, but, after 6 h inhibition was almost total in tomato fruit incubated at 42 degrees C. However, recovery of ethylene production was rapid if fruit...

    journal_title：Magnetic resonance imaging

    pub_type： 杂志文章

    doi：10.1016/s0730-725x(98)00219-7

    authors： Iwahashi Y,Horigane AK,Yoza K,Nagata T,Hosoda H

    更新日期：1999-06-01 00:00:00

  • Explicit treatment of mutual inductance in eight-column birdcage resonators.

    abstract：:A formulation has been developed for the determination of self and mutual inductances in unloaded, eight-column symmetric birdcage coils using their expected resonant mode current patterns and well-known inductance formulas. The average frequency differences between theory and experiment for mode one resonances for ni...

    journal_title：Magnetic resonance imaging

    pub_type： 杂志文章

    doi：10.1016/0730-725x(92)90511-w

    authors： Pascone R,Vullo T,Farrelly J,Cahill PT

    更新日期：1992-01-01 00:00:00

  • Diffusional kurtosis imaging of cingulate fibers in Parkinson disease: comparison with conventional diffusion tensor imaging.

    abstract：OBJECTIVE:The pathological changes in Parkinson disease begin in the brainstem; reach the limbic system and ultimately spread to the cerebral cortex. In Parkinson disease (PD) patients, we evaluated the alteration of cingulate fibers, which comprise part of the limbic system, by using diffusional kurtosis imaging (DKI)...

    journal_title：Magnetic resonance imaging

    pub_type： 杂志文章

    doi：10.1016/j.mri.2013.06.009

    authors： Kamagata K,Tomiyama H,Motoi Y,Kano M,Abe O,Ito K,Shimoji K,Suzuki M,Hori M,Nakanishi A,Kuwatsuru R,Sasai K,Aoki S,Hattori N

    更新日期：2013-11-01 00:00:00

  • Quantification of venous blood signal contribution to BOLD functional activation in the auditory cortex at 3 T.

    abstract：:Most modern techniques for functional magnetic resonance imaging (fMRI) rely on blood-oxygen-level-dependent (BOLD) contrast as the basic principle for detecting neuronal activation. However, the measured BOLD effect depends on a transfer function related to neurophysiological changes accompanying electrical neural ac...

    journal_title：Magnetic resonance imaging

    pub_type： 杂志文章

    doi：10.1016/j.mri.2008.02.006

    authors： Casciaro S,Bianco R,Distante A

    更新日期：2008-11-01 00:00:00

  • A robust electrical conductivity imaging method with total variation and wavelet regularization.

    abstract：PURPOSE:This study aims to develop and evaluate a robust conductivity imaging method that combines total variation and wavelet regularization to enhance the accuracy of conductivity maps. THEORY AND METHODS:The proposed approach is based on a gradient-based method. The central equation is derived from Maxwell's equati...

    journal_title：Magnetic resonance imaging

    pub_type： 杂志文章

    doi：10.1016/j.mri.2020.02.015

    authors： Sun X,Lu L,Qi L,Mei Y,Liu X,Chen W

    更新日期：2020-06-01 00:00:00

  • Electrophoretic NMR studies of electrical transport in fluid-filled porous systems.

    abstract：:An NMR technique is described which allows the observation of ionic charge carriers moving in the electric field within a porous system saturated with electrolyte solution. This method, which was recently developed in our laboratory, gives experimental access to the study of electric transport in disordered media on a...

    journal_title：Magnetic resonance imaging

    pub_type： 杂志文章

    doi：10.1016/s0730-725x(01)00267-3

    authors： Holz M,Heil SR,Schwab IA

    更新日期：2001-04-01 00:00:00

  • Wavelet-based characterization of vertebral trabecular bone structure from magnetic resonance images at 3 T compared with micro-computed tomographic measurements.

    abstract：:Trabecular bone structure and bone density contribute to the strength of bone and are important in the study of osteoporosis. Wavelets are a powerful tool in characterizing and quantifying texture in an image. The purpose of this study was to validate wavelets as a tool in computing trabecular bone thickness directly ...

    journal_title：Magnetic resonance imaging

    pub_type： 杂志文章

    doi：10.1016/j.mri.2006.09.020

    authors： Krug R,Carballido-Gamio J,Burghardt AJ,Haase S,Sedat JW,Moss WC,Majumdar S

    更新日期：2007-04-01 00:00:00

  • Bilateral neurostimulation systems used for deep brain stimulation: in vitro study of MRI-related heating at 1.5 T and implications for clinical imaging of the brain.

    abstract：:Deep brain stimulation (DBS) is used increasingly in the field of movement disorders. The implanted electrodes create not only a prior risk to patient safety during MRI, but also a unique opportunity in the collection of functional MRI data conditioned by direct neural stimulation. We evaluated MRI-related heating for...

    journal_title：Magnetic resonance imaging

    pub_type： 杂志文章

    doi：10.1016/j.mri.2005.02.007

    authors： Bhidayasiri R,Bronstein JM,Sinha S,Krahl SE,Ahn S,Behnke EJ,Cohen MS,Frysinger R,Shellock FG

    更新日期：2005-05-01 00:00:00

  • Measuring pore connectivity by pulsed field gradient diffusion editing with hydrocarbon gases.

    abstract：:Measurements of time-dependent diffusion are performed on a rock sample saturated first with water, then methane and finally ethane. The gases were selected because their increased diffusivities and relaxation times allow probing greater length scales than water and because of their practical relevance. The nuclear ma...

    journal_title：Magnetic resonance imaging

    pub_type： 杂志文章

    doi：10.1016/j.mri.2005.01.002

    authors： Flaum M,Hirasaki GJ,Flaum C,Straley C

    更新日期：2005-02-01 00:00:00

  • Fat ViP MRI: Virtual Phantom Magnetic Resonance Imaging of water-fat systems.

    abstract：OBJECT:Virtual Phantom Magnetic Resonance Imaging (ViP MRI) is a method to generate reference signals on MR images, using external radiofrequency (RF) signals. The aim of this study was to assess the feasibility of ViP MRI to generate complex-data images of phantoms mimicking water-fat systems. MATERIALS AND METHODS:V...

    journal_title：Magnetic resonance imaging

    pub_type： 杂志文章

    doi：10.1016/j.mri.2015.12.002

    authors： Salvati R,Hitti E,Bellanger JJ,Saint-Jalmes H,Gambarota G

    更新日期：2016-06-01 00:00:00

  • Three dimensional k-space trajectory design using genetic algorithms.

    abstract：:Image quality and total scan time in MRI are determined in large part by the trajectory employed to sample the Fourier space. Each trajectory has different properties like coverage of k-space, scan time, sensitivity to off-resonance conditions, etc. These properties are often contradictory, therefore a universal optim...

    journal_title：Magnetic resonance imaging

    pub_type： 杂志文章

    doi：10.1016/s0730-725x(03)00174-7

    authors： Sabat S,Mir R,Guarini M,Guesalaga A,Irarrazaval P

    更新日期：2003-09-01 00:00:00

  • Phase gradient imaging for positive contrast generation to superparamagnetic iron oxide nanoparticle-labeled targets in magnetic resonance imaging.

    abstract：:Positive contrast imaging methods produce enhanced signal at large magnetic field gradient in magnetic resonance imaging. Several postprocessing algorithms, such as susceptibility gradient mapping and phase gradient mapping methods, have been applied for positive contrast generation to detect the cells targeted by sup...

    journal_title：Magnetic resonance imaging

    pub_type： 杂志文章

    doi：10.1016/j.mri.2011.04.011

    authors： Zhu H,Demachi K,Sekino M

    更新日期：2011-09-01 00:00:00

  • Probe efficiency improvement with remote and transmission line tuning and matching.

    abstract：:In certain nuclear magnetic resonance (NMR) applications in which accessibility to the gantry is limited, performing optimal tuning and matching represents a major problem. Here, we discuss a method of tuning NMR probe circuits and matching their impedances which uses cables with different impedance values. This simpl...

    journal_title：Magnetic resonance imaging

    pub_type： 杂志文章

    doi：10.1016/s0730-725x(99)00051-x

    authors： Villa P,Vaquero JJ,Chesnick S,Ruiz-Cabello J

    更新日期：1999-09-01 00:00:00

  • Comparison between end-tidal CO₂ and respiration volume per time for detecting BOLD signal fluctuations during paced hyperventilation.

    abstract：:Respiratory motion and capnometry monitoring were performed during blood oxygen level-dependent (BOLD) functional magnetic resonance imaging (fMRI) of the brain while a series of paced hyperventilation tasks were performed that caused significant hypocapnia. Respiration volume per time (RVT) and end-tidal carbon dioxi...

    journal_title：Magnetic resonance imaging

    pub_type： 杂志文章

    doi：10.1016/j.mri.2011.07.011

    authors： Vogt KM,Ibinson JW,Schmalbrock P,Small RH

    更新日期：2011-11-01 00:00:00

  • Empirical optimization of ASL data analysis using an ASL data processing toolbox: ASLtbx.

    abstract：:Arterial spin labeling (ASL) perfusion fMRI data differ in important respects from the more familiar blood oxygen level-dependent (BOLD) fMRI data and require specific processing strategies. In this paper, we examined several factors that may influence ASL data analysis, including data storage bit resolution, motion c...

    journal_title：Magnetic resonance imaging

    pub_type： 杂志文章

    doi：10.1016/j.mri.2007.07.003

    authors： Wang Z,Aguirre GK,Rao H,Wang J,Fernández-Seara MA,Childress AR,Detre JA

    更新日期：2008-02-01 00:00:00

  • Assessment of transplant renal artery stenosis with diffusion-weighted imaging: A preliminary study.

    abstract：OBJECTIVE:To characterize capillary perfusion and tissue diffusion changes in transplant renal artery stenosis (TRAS) with diffusion-weighted imaging (DWI). MATERIALS & METHODS:We retrospectively identified 30 patients with non-contrast enhanced magnetic resonance angiography-proven TRAS. Another 20 kidney transplant ...

    journal_title：Magnetic resonance imaging

    pub_type： 杂志文章

    doi：10.1016/j.mri.2019.05.007

    authors： Fan M,Ni X,Li Y,Chen J,Cheng D,Shi D,He X,Wen J

    更新日期：2019-07-01 00:00:00

  • Reduced distortion artifact whole brain CBF mapping using blip-reversed non-segmented 3D echo planar imaging with pseudo-continuous arterial spin labeling.

    abstract：PURPOSE:To implement and evaluate interleaved blip-up, blip-down, non-segmented 3D echo planar imaging (EPI) with pseudo-continuous arterial spin labeling (pCASL) and post-processing for reduced susceptibility artifact cerebral blood flow (CBF) maps. MATERIALS AND METHODS:3D EPI non-segmented acquisition with a pCASL ...

    journal_title：Magnetic resonance imaging

    pub_type： 杂志文章

    doi：10.1016/j.mri.2017.08.011

    authors： Gai ND,Chou YY,Pham D,Butman JA

    更新日期：2017-12-01 00:00:00

  • A fast spin echo two-point Dixon technique and its combination with sensitivity encoding for efficient T2-weighted imaging.

    abstract：:A fast spin echo two-point Dixon (fast 2PD) technique was developed for efficient T2-weighted imaging with uniform water and fat separation. The technique acquires two interleaved fast spin echo images with water and fat in-phase and 180 degrees out-of-phase, respectively, and generates automatically separate water an...

    journal_title：Magnetic resonance imaging

    pub_type： 杂志文章

    doi：10.1016/j.mri.2005.10.005

    authors： Ma J,Son JB,Bankson JA,Stafford RJ,Choi H,Ragan D

    更新日期：2005-12-01 00:00:00

  • Different magnetic resonance imaging features in two types of nontraumatic rabbit osteonecrosis models.

    abstract：:A single injection of high-dose steroid (20 mg/kg) has been reported to induce necrotic lesions in the proximal metaphysis and diaphysis of the rabbit femur. In the rabbit osteonecrosis (ON) model induced by two-dose horse serum injections, contrast-enhanced magnetic resonance imaging (MRI) and T2*-weighted dynamic MR...

    journal_title：Magnetic resonance imaging

    pub_type： 杂志文章

    doi：10.1016/j.mri.2008.07.001

    authors： Takao M,Sugano N,Nishii T,Sakai T,Nakamura N,Yoshikawa H

    更新日期：2009-02-01 00:00:00

  • Evaluation of water content by spatially resolved transverse relaxation times of human articular cartilage.

    abstract：:Non-invasive assessment of cartilage properties, specifically water content, could prove helpful in the diagnosis of early degenerative joint diseases. Transverse relaxation times T(2) of human articular cartilage (34 cartilage slices of three donors) were measured on a pixel-by-pixel basis in a clinical whole body MR...

    journal_title：Magnetic resonance imaging

    pub_type： 杂志文章

    doi：10.1016/s0730-725x(99)00144-7

    authors： Lüsse S,Claassen H,Gehrke T,Hassenpflug J,Schünke M,Heller M,Glüer CC

    更新日期：2000-05-01 00:00:00

  • Balanced steady state free precession for arterial spin labeling MRI: Initial experience for blood flow mapping in human brain, retina, and kidney.

    abstract：:We implemented pseudo-continuous ASL (pCASL) with 2D and 3D balanced steady state free precession (bSSFP) readout for mapping blood flow in the human brain, retina, and kidney, free of distortion and signal dropout, which are typically observed in the most commonly used echo-planar imaging acquisition. High resolution...

    journal_title：Magnetic resonance imaging

    pub_type： 杂志文章

    doi：10.1016/j.mri.2013.03.024

    authors： Park SH,Wang DJ,Duong TQ

    更新日期：2013-09-01 00:00:00