Dependence of temporal diffusion spectra on microstructural properties of biological tissues.


:The apparent diffusion coefficient (ADC) measured using magnetic resonance imaging methods provides information on microstructural properties of biological tissues, and thus has found applications as a useful biomarker for assessing changes such as those that occur in ischemic stroke and cancer. Conventional pulsed gradient spin echo methods are in widespread use and provide information on, for example, variations in cell density. The oscillating gradient spin echo (OGSE) method has the additional ability to probe diffusion behaviors more readily at short diffusion times, and the temporal diffusion spectrum obtained by the OGSE method provides a unique tool for characterizing tissues over different length scales, including structural features of intracellular spaces. It has previously been reported that several tissue properties can affect ADC measurements significantly, and the precise biophysical mechanisms that account for ADC changes in different situations are still unclear. Those factors may vary in importance depending on the time and length scale over which measurements are made. In the present work, a comprehensive numerical simulation is used to investigate the dependence of the temporal diffusion spectra measured by OGSE methods on different microstructural properties of biological tissues, including cell size, cell membrane permeability, intracellular volume fraction, intranucleus and intracytoplasm diffusion coefficients, nuclear size and T(2) relaxation times. Some unique characteristics of the OGSE method at relatively high frequencies are revealed. The results presented in the paper offer a framework for better understanding possible causes of diffusion changes and may be useful to assist the interpretation of diffusion data from OGSE measurements.


Magn Reson Imaging


Xu J,Does MD,Gore JC




Has Abstract


2011-04-01 00:00:00














  • The NMR-MOUSE: quality control of elastomers.

    abstract::New applications of the NMR-MOUSE (mobile universal surface explorer) to non-destructive quality control of elastomers are reported. One example concern the thermal aging of fast clutches which was probed by measurements of 1H transverse relaxation time. Novel methodological developments show that 1H double-quantum fi...

    journal_title:Magnetic resonance imaging

    pub_type: 杂志文章


    authors: Kühn H,Klein M,Wiesmath A,Demco DE,Blümich B,Kelm J,Gold PW

    更新日期:2001-04-01 00:00:00

  • Computer-assisted design of surface coils used in magnetic resonance imaging. I. The calculation of the magnetic field.

    abstract::For a number of reasons, it is desirable to fabricate coils which, for a known current, shall produce predetermined values of the magnetic field intensity at a number of points within a nuclear magnetic resonance imager. The calculation of the magnetic field intensity at a set of points involves the integration of the...

    journal_title:Magnetic resonance imaging

    pub_type: 杂志文章


    authors: Letcher JH

    更新日期:1989-11-01 00:00:00

  • Delayed myelination in a rhizomelic chondrodysplasia punctata case: MR spectroscopy findings.

    abstract::Rhizomelic chondrodysplasia punctata is a member of genetic peroxisomal disorders. Delayed myelination, which is probably related to the inadequacy of plasmalogens biosynthesis, is an important feature of this disorder. Direct assessment of neuropathologic aspects of RCDP syndrome such as neuronal degeneration and del...

    journal_title:Magnetic resonance imaging

    pub_type: 杂志文章


    authors: Alkan A,Kutlu R,Yakinci C,Sigirci A,Aslan M,Sarac K

    更新日期:2003-01-01 00:00:00

  • 7T GRE-MRI signal compartments are sensitive to dysplastic tissue in focal epilepsy.

    abstract::Ultra-high field magnetic resonance imaging data obtained using a multi-echo gradient echo sequence has been shown to contain information on tissue microstructure. Quantitative assessment of water fraction, relaxation time and frequency shift using multi-compartment signal modelling may help improve our understanding ...

    journal_title:Magnetic resonance imaging

    pub_type: 杂志文章


    authors: Thapaliya K,Urriola J,Barth M,Reutens DC,Bollmann S,Vegh V

    更新日期:2019-09-01 00:00:00

  • Increasing mean airway pressure reduces functional MRI (fMRI) signal in the primary visual cortex.

    abstract::Changes in both blood flow and blood oxygenation determine the functional MRI (fMRI) signal. In the present study factors responsible for blood oxygenation (e.g., FiO(2)) were held constant so that changes in pixel count would above all reflect changes in regional cerebral blood flow (rCBF). Continuous positive airway...

    journal_title:Magnetic resonance imaging

    pub_type: 杂志文章


    authors: Lorenz IH,Kolbitsch C,Hörmann C,Schocke M,Kremser C,Zschiegner F,Felber S,Benzer A

    更新日期:2001-01-01 00:00:00

  • Factors influencing contrast in fast spin-echo MR imaging.

    abstract::Multi-echo pulse sequences for producing T2-weighted images in much reduced imaging times have recently been developed for routine clinical use. A number of recent articles have described the contrast obtained with fast spin-echo (FSE) sequences and have generally indicated that they depict tissues very similarly to c...

    journal_title:Magnetic resonance imaging

    pub_type: 杂志文章,评审


    authors: Constable RT,Anderson AW,Zhong J,Gore JC

    更新日期:1992-01-01 00:00:00

  • Identification and characterization of biological tissues by NMR. Concerted research project of the European Economic Community. Introduction, objectives, and activities.

    abstract::NMR offers, in the complex proton relaxation properties of biological tissues, a unique and potentially powerful tool of tissue characterization. The difficulties encountered so far in comparing the results of in vitro and in vivo NMR studies carried out in different laboratories inhibit NMR methodologies from fully e...

    journal_title:Magnetic resonance imaging

    pub_type: 杂志文章


    authors: Podo F,Orr JS,Schmidt KH,Bovée WM

    更新日期:1988-03-01 00:00:00

  • Area of paradoxical signal drop after the administration of superparamagnetic iron oxide on the T2-weighted image of a patient with lymphangitic metastasis of the liver.

    abstract::We report a geographic area of prominent hypointensity in T2-weighted images vs. normal adjacent liver parenchyma in a patient with cholangiocarcinoma and lymphangitic metastasis of the liver after superparamagnetic iron oxide (SPIO) administration. The area showing this prominent signal drop showed Kupffer cell proli...

    journal_title:Magnetic resonance imaging

    pub_type: 杂志文章


    authors: Lee Y,Lee JS,Kim CM,Jeong JY,Choi JI,Kim MJ

    更新日期:2008-05-01 00:00:00

  • Idiopathic dilatation of the pulmonary artery: report of four cases.

    abstract::Idiopathic dilatation of the pulmonary artery (IDPA) is a rare congenital disease which is usually detected fortuitously on chest x-ray, thus radiologists must be aware of this clinical entity. This report describes four cases to which Magnetic Resonance Imaging (MRI) played a major role in diagnosing IDPA and in dete...

    journal_title:Magnetic resonance imaging

    pub_type: 杂志文章


    authors: Ugolini P,Mousseaux E,Sadou Y,Sidi D,Mercier LA,Paquet E,Gaux JC

    更新日期:1999-07-01 00:00:00

  • Improved optimization strategies for autofocusing motion compensation in MRI via the analysis of image metric maps.

    abstract::Autofocusing is a postprocessing technique for motion correction, which optimizes an image quality metric against various trial motions. In this work, image metric maps, which are measures of image quality plotted as a function of in-plane 2-D trial translations, are systematically studied to develop improved autofocu...

    journal_title:Magnetic resonance imaging

    pub_type: 杂志文章


    authors: Lin W,Song HK

    更新日期:2006-07-01 00:00:00

  • In vivo mapping of functional domains and axonal connectivity in cat visual cortex using magnetic resonance imaging.

    abstract::Noninvasive cognitive neuroimaging studies based on functional magnetic resonance imaging (fMRI) are of ever-increasing importance for basic and clinical neurosciences. The explanatory power of fMRI could be greatly expanded, however, if the pattern of the neuronal circuitry underlying functional activation could be m...

    journal_title:Magnetic resonance imaging

    pub_type: 杂志文章


    authors: Kim DS,Kim M,Ronen I,Formisano E,Kim KH,Ugurbil K,Mori S,Goebel R

    更新日期:2003-12-01 00:00:00

  • Optimal real-time estimation in diffusion tensor imaging.

    abstract::Diffusion tensor imaging (DTI) constitutes the most used paradigm among the diffusion-weighted magnetic resonance imaging (DW-MRI) techniques due to its simplicity and application potential. Recently, real-time estimation in DW-MRI has deserved special attention, with several proposals aiming at the estimation of mean...

    journal_title:Magnetic resonance imaging

    pub_type: 杂志文章


    authors: Casaseca-de-la-Higuera P,Tristán-Vega A,Aja-Fernández S,Alberola-López C,Westin CF,San José Estépar R

    更新日期:2012-05-01 00:00:00

  • MRI of the normal hippocampus.

    abstract::Before it is possible to use MR imaging to investigate changes in the hippocampus in disease processes such as epilepsy and memory disorders, it is imperative that normal variations are defined. Using specific anatomic locations, we evaluated the hippocampi of 29 normal volunteers with coronal MR studies. Mild variati...

    journal_title:Magnetic resonance imaging

    pub_type: 杂志文章


    authors: Bronen RA,Cheung G

    更新日期:1991-01-01 00:00:00

  • Balanced steady state free precession for arterial spin labeling MRI: Initial experience for blood flow mapping in human brain, retina, and kidney.

    abstract::We implemented pseudo-continuous ASL (pCASL) with 2D and 3D balanced steady state free precession (bSSFP) readout for mapping blood flow in the human brain, retina, and kidney, free of distortion and signal dropout, which are typically observed in the most commonly used echo-planar imaging acquisition. High resolution...

    journal_title:Magnetic resonance imaging

    pub_type: 杂志文章


    authors: Park SH,Wang DJ,Duong TQ

    更新日期:2013-09-01 00:00:00

  • Issues about the fMRI of the human spinal cord.

    abstract::Noninvasive functional studies on human spinal cord by means of magnetic resonance imaging (MRI) are gaining attention because of the promising applications in the study of healthy and injured central nervous system. The findings obtained are generally consistent with the anatomic knowledge based on invasive methods, ...

    journal_title:Magnetic resonance imaging

    pub_type: 杂志文章,评审


    authors: Giove F,Garreffa G,Giulietti G,Mangia S,Colonnese C,Maraviglia B

    更新日期:2004-12-01 00:00:00

  • Cardiac magnetic resonance tissue tracking in right ventricle: Feasibility and normal values.

    abstract:PURPOSE:To investigate right ventricular (RV) strain in patients without identified cardiac pathology using cardiac magnetic resonance tissue tracking (CMR TT). METHODS:A total of 50 consecutive patients with no identified cardiac pathology were analyzed. RV longitudinal and circumferential strain was assessed by CMR ...

    journal_title:Magnetic resonance imaging

    pub_type: 杂志文章


    authors: Truong VT,Safdar KS,Kalra DK,Gao X,Ambach S,Taylor MD,Moore R,Taylor RJ,Germann J,Toro-Salazar O,Jefferies JL,Bartone C,Raman SV,Ngo T,Mazur W

    更新日期:2017-05-01 00:00:00

  • Non-Gaussian diffusion MRI assessment of brain microstructure in mild cognitive impairment and Alzheimer's disease.

    abstract::We report the first application of a novel diffusion-based MRI method, called diffusional kurtosis imaging (DKI), to investigate changes in brain tissue microstructure in patients with mild cognitive impairment (MCI) and AD and in cognitively intact controls. The subject groups were characterized and compared in terms...

    journal_title:Magnetic resonance imaging

    pub_type: 杂志文章


    authors: Falangola MF,Jensen JH,Tabesh A,Hu C,Deardorff RL,Babb JS,Ferris S,Helpern JA

    更新日期:2013-07-01 00:00:00

  • Correlation of apparent diffusion coefficient and intravoxel incoherent motion imaging parameters with Ki-67 expression in extrahepatic cholangiocarcinoma.

    abstract:PURPOSE:To investigate the correlation of magnetic resonance imaging (MRI), apparent diffusion coefficient (ADC) and intravoxel incoherent motion imaging parameters with Ki-67 expression in cholangiocarcinoma. METHODS:A total of 42 extrahepatic cholangiocarcinoma (EHCC) cases confirmed by surgical pathology were analy...

    journal_title:Magnetic resonance imaging

    pub_type: 杂志文章


    authors: Cui X,Chen H,Cai S,Tang Q,Fang X

    更新日期:2019-11-01 00:00:00

  • Development and validation of a novel large field of view phantom and a software module for the quality assurance of geometric distortion in magnetic resonance imaging.

    abstract:OBJECTIVE:To develop and validate a large field of view phantom and quality assurance software tool for the assessment and characterization of geometric distortion in MRI scanners commissioned for radiation therapy planning. MATERIALS AND METHODS:A purpose built phantom was developed consisting of 357 rods (6mm in dia...

    journal_title:Magnetic resonance imaging

    pub_type: 杂志文章,评审


    authors: Torfeh T,Hammoud R,McGarry M,Al-Hammadi N,Perkins G

    更新日期:2015-09-01 00:00:00

  • Diffusion pore imaging with generalized temporal gradient profiles.

    abstract::In porous material research, one main interest of nuclear magnetic resonance diffusion (NMR) experiments is the determination of the shape of pores. While it has been a longstanding question if this is in principle achievable, it has been shown recently that it is indeed possible to perform NMR-based diffusion pore im...

    journal_title:Magnetic resonance imaging

    pub_type: 杂志文章


    authors: Laun FB,Kuder TA

    更新日期:2013-09-01 00:00:00

  • Effects of 3D sampling in (k, t)-space on temporal qualities of dynamic MRI.

    abstract::3D (kx, ky, t)-space analysis is invoked to provide insights into dynamic magnetic resonance imaging (DMRI) with arbitrary k-space sampling trajectories. The effects of 3D sampling in (kx, ky, t) are analyzed theoretically and verified with computer simulation. The analyses show that a 3D sampling pattern that is more...

    journal_title:Magnetic resonance imaging

    pub_type: 杂志文章


    authors: Park JB,Nishimura DG

    更新日期:2006-10-01 00:00:00

  • Artifacts in magnetic resonance imaging after surgical resection of brain tumors.

    abstract:BACKGROUND:Since the advent of magnetic resonance imaging, metal artifacts have posed an important diagnostic problem in different fields of medicine. However, this has not been systematically studied in patients undergoing surgery for brain tumors. OBJECTIVE:This study was planned to assess whether metal artifacts ca...

    journal_title:Magnetic resonance imaging

    pub_type: 杂志文章


    authors: Bagheri MH,Ahmadloo N,Rezaian S

    更新日期:2013-06-01 00:00:00

  • Dielectric resonances and B(1) field inhomogeneity in UHFMRI: computational analysis and experimental findings.

    abstract::B(1) Field inhomogeneity and the relative effects of dielectric resonances are analyzed within the context of ultra high field MRI. This is accomplished by calculating the electromagnetic fields inside spherical phantoms and within a human head model in the presence and absence of an RF coil. These calculations are th...

    journal_title:Magnetic resonance imaging

    pub_type: 杂志文章


    authors: Ibrahim TS,Lee R,Abduljalil AM,Baertlein BA,Robitaille PM

    更新日期:2001-02-01 00:00:00

  • Preparation, physico-chemical characterization, and relaxometry studies of various gadolinium(III)-DTPA-bis(amide) derivatives as potential magnetic resonance contrast agents.

    abstract::Macroscopic protonation constants were measured for a series of DTPA mono- and bis-amide ligands using potentiometric titrations. Proton NMR pH titrations yielded protonation populations of the various nitrogen and oxygen basic sites of the ligands for the different protonation stages. Amide formation decreased the ba...

    journal_title:Magnetic resonance imaging

    pub_type: 杂志文章


    authors: Geraldes CF,Urbano AM,Alpoim MC,Sherry AD,Kuan KT,Rajagopalan R,Maton F,Muller RN

    更新日期:1995-01-01 00:00:00

  • Incidental magnetization transfer contrast in standard multislice imaging.

    abstract::Radio frequency magnetic fields from 5 to 100 kHz off resonance reduce longitudinal magnetization of water in some tissues without affecting the magnetization of simple solutions (Wolff, S.D.; Balaban, R.S. Magnetization transfer contrast (MTC) and tissue water proton relaxation in vivo. Magn. Reson. Med. 10:135-144; ...

    journal_title:Magnetic resonance imaging

    pub_type: 杂志文章


    authors: Dixon WT,Engels H,Castillo M,Sardashti M

    更新日期:1990-01-01 00:00:00

  • Comparison of BLADE and conventional T2-TSE sequences for the sagittal visualization of the cervical spinal cord in multiple sclerosis patients - a case report.

    abstract::The purpose of this study is to report the significant differences found in the identification of lesions in cervical spinal cord of two patients with multiple sclerosis when using the BLADE T2-TSE and BLADE T2-TIRM sequences as opposed to the conventional T2-TSE and T2-TIRM sequences for sagittal acquisition at 1.5T....

    journal_title:Magnetic resonance imaging

    pub_type: 杂志文章


    authors: Lavdas E,Mavroidis P,Topaltzikis T,Slatinopoulos V,Roka V,Vlachopoulou A,Papanikolaou N,Stathakis S,Kapsalaki E,Batsikas G

    更新日期:2013-12-01 00:00:00

  • Non-contrast enhanced 3D SSFP MRA of the renal allograft vasculature: a comparison between radial linear combination and Cartesian inflow-weighted acquisitions.

    abstract::Renal transplant patients often require imaging to ensure appropriate graft placement, to assess integrity of transplant vessel anastomosis and to evaluate for stenosis that can be a cause of graft failure. Because there is risk for nephrogenic systemic fibrosis in the setting of renal insufficiency, the use of non-co...

    journal_title:Magnetic resonance imaging

    pub_type: 杂志文章


    authors: Bultman EM,Klaers J,Johnson KM,François CJ,Schiebler ML,Reeder SB,Block WF

    更新日期:2014-02-01 00:00:00

  • On the R2⁎ relaxometry in complex multi-peak multi-Echo chemical shift-based water-fat quantification: Applications to the neuromuscular diseases.

    abstract:PURPOSE:Investigation of the feasibility of the R2⁎ mapping techniques by using latest theoretical models corrected for confounding factors and optimized for signal to noise ratio. THEORY AND METHODS:The improvement of the performance of state of the art magnetic resonance imaging (MRI) relaxometry algorithms is chall...

    journal_title:Magnetic resonance imaging

    pub_type: 杂志文章


    authors: Siracusano G,La Corte A,Milazzo C,Anastasi GP,Finocchio G,Gaeta M

    更新日期:2017-01-01 00:00:00

  • MR characteristics of neoplasms and vascular malformations associated with epilepsy.

    abstract::We assessed the magnetic resonance (MR) imaging characteristics of two categories of epileptogenic substrates, neoplasms, and vascular malformations, to determine MR sensitivity and typical imaging features. A blinded retrospective analysis was performed on MR scans from 41 patients who had a neoplasm or vascular malf...

    journal_title:Magnetic resonance imaging

    pub_type: 杂志文章


    authors: Bronen RA,Fulbright RK,Spencer DD,Spencer SS,Kim JH,Lange RC

    更新日期:1995-01-01 00:00:00

  • Surface coil imaging of rat spine at 7.0 T.

    abstract::An inductively coupled surface coil for imaging the rat spine at 7 T is described. This planar circular probe was made from microwave substrate to limit the size of the coil and to minimize the magnetic susceptibility. The surface coil was used as a single transmit/receive coil and as a receive-only coil with a birdca...

    journal_title:Magnetic resonance imaging

    pub_type: 杂志文章


    authors: Banson ML,Cofer GP,Hedlund LW,Johnson GA

    更新日期:1992-01-01 00:00:00