Abstract：
:Functional magnetic resonance imaging (fMRI) was performed on a conventional 1.5 T scanner by means of a modified FLASH-technique at temporal resolutions of 80 and 320 ms. The method's stability was assessed by phantom measurements and by investigation of three volunteers resulting in a low amplitude (3%) periodic (4 s) signal modulation for the in vivo measurements, which was not observable in the phantom experiments. fMRI activation studies of motor and visual cortices of four adjacent slices were carried out on 12 healthy right-handed volunteers. Stimulation was performed by a triggered single white light flash or single finger-to-thumb opposition movement, respectively. Event-related response of visual and motor activation was traced over 10.24 s with a temporal resolution of 320 ms for the four slice measurements. Brain activation maps were calculated by correlation of measured signal time course with a time-shifted boxcar function. Activation was quantified by calculation of percentual signal change in relation to the baseline. Observed signal magnitudes were about 5-7% in visual and about 8-12% in primary motor cortex. While photic response was delayed by about 2 s, motor stimulation showed an instantaneous increase of the MR signal. MR signal responses for both stimuli had decayed completely after about 5 s. Our results show that event-related fMRI enables mapping of brain function at sufficient spatial resolution with a temporal resolution of up to 80 ms on a conventional scanner.
journal_name
Magn Reson Imagingjournal_title
Magnetic resonance imagingauthors
Wiener E,Schad LR,Baudendistel KT,Essig M,Müller E,Lorenz WJdoi
10.1016/0730-725x(96)00021-5subject
Has Abstractpub_date
1996-01-01 00:00:00pages
477-83issue
5eissn
0730-725Xissn
1873-5894pii
0730725X96000215journal_volume
14pub_type
杂志文章abstract：:The metabolism of 5-fluorouracil (5-FU) is complex and the reason for the low response rate of tumor patients to 5-FU is currently unknown. The aim of this study was to evaluate whether spectral parameters obtained noninvasively by in vivo 19F nuclear magnetic resonance (NMR) spectroscopy can be used to assess individ...
journal_title：Magnetic resonance imaging
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journal_title：Magnetic resonance imaging
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journal_title：Magnetic resonance imaging
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journal_title：Magnetic resonance imaging
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journal_title：Magnetic resonance imaging
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journal_title：Magnetic resonance imaging
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journal_title：Magnetic resonance imaging
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journal_title：Magnetic resonance imaging
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journal_title：Magnetic resonance imaging
pub_type： 杂志文章
doi：10.1016/j.mri.2004.01.073
更新日期：2004-06-01 00:00:00
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journal_title：Magnetic resonance imaging
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更新日期：2000-10-01 00:00:00
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journal_title：Magnetic resonance imaging
pub_type： 杂志文章
doi：10.1016/j.mri.2004.11.067
更新日期：2005-02-01 00:00:00
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更新日期：2015-01-01 00:00:00
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journal_title：Magnetic resonance imaging
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doi：10.1016/j.mri.2020.09.005
更新日期：2020-12-01 00:00:00
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journal_title：Magnetic resonance imaging
pub_type： 杂志文章
doi：10.1016/j.mri.2003.01.001
更新日期：2004-01-01 00:00:00
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journal_title：Magnetic resonance imaging
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doi：10.1016/j.mri.2016.04.005
更新日期：2016-10-01 00:00:00
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journal_title：Magnetic resonance imaging
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doi：10.1016/j.mri.2004.02.005
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journal_title：Magnetic resonance imaging
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journal_title：Magnetic resonance imaging
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doi：10.1016/j.mri.2005.07.011
更新日期：2005-11-01 00:00:00
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journal_title：Magnetic resonance imaging
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journal_title：Magnetic resonance imaging
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doi：10.1016/0730-725x(89)90538-9
更新日期：1989-11-01 00:00:00
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journal_title：Magnetic resonance imaging
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更新日期：2008-02-01 00:00:00
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journal_title：Magnetic resonance imaging
pub_type： 杂志文章
doi：10.1016/j.mri.2015.06.015
更新日期：2015-11-01 00:00:00
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journal_title：Magnetic resonance imaging
pub_type： 杂志文章,评审
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更新日期：2015-09-01 00:00:00
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journal_title：Magnetic resonance imaging
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journal_title：Magnetic resonance imaging
pub_type： 杂志文章
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更新日期：1997-01-01 00:00:00
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journal_title：Magnetic resonance imaging
pub_type： 杂志文章
doi：10.1016/j.mri.2019.11.006
更新日期：2020-02-01 00:00:00
