Abstract:
:1H Magnetic resonance imaging and 31P magnetic resonance spectroscopy (MRS) have been carried out in experimental rodent filariasis, i.e., Acanthocheilonema viteae infection in the rodent host, Mastomys coucha. The T2-weighted image of the infected host shows fine hyperintense thread like structures of adult filariid nests in the cervical region. 31P MRS of normal and infected hosts, localized over the same region of interest, show seven major peaks corresponding to phosphomonoesters (including glucose-6-phosphate, fructose-6-phosphate, fructose-1-6-diphosphate, phosphorylcholine, and adenine monophosphate or AMP), inorganic phosphate, glycerophosphorylcholine, phosphoenolpyruvate, phosphocreatine and nucleoside di- and tri-phosphates. Concentrations of phosphomonoesters (PMEs) are higher in the normal rodent compared with the infected ones. In vivo 31P MRS provides a non-invasive assessment of tissue bioenergetics and phospholipid metabolism.
journal_name
Magn Reson Imagingjournal_title
Magnetic resonance imagingauthors
Shukla-Dave A,Fatma N,Roy R,Srivastava S,Chatterjee RK,Govindaraju V,Viswanathan AK,Raghunathan Pdoi
10.1016/s0730-725x(97)00180-xsubject
Has Abstractpub_date
1997-01-01 00:00:00pages
1193-8issue
10eissn
0730-725Xissn
1873-5894pii
S0730-725X(97)00180-Xjournal_volume
15pub_type
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