Diffusion tensor imaging of native and degenerated human articular cartilage.

Abstract:

:Diffusion tensor imaging (DTI) is potentially sensitive to collagen degeneration in cartilage. In this study, DTI was measured on human cartilage samples with interventions of trypsin and collagenase. The measured preferred diffusion direction was consistent with the zonal structure of collagen network. The glycosaminoglycan concentration decreased and apparent diffusion coefficient increased with both interventions. The fractional anisotropy (FA) was not affected by trypsin and showed a slight increase with combined trypsin and collagenase intervention. DTI in cartilage is technically challenging due to the low FA and the almost undetectable change with collagen disruption seen here.

journal_name

Magn Reson Imaging

authors

Deng X,Farley M,Nieminen MT,Gray M,Burstein D

doi

10.1016/j.mri.2006.10.015

subject

Has Abstract

pub_date

2007-02-01 00:00:00

pages

168-71

issue

2

eissn

0730-725X

issn

1873-5894

pii

S0730-725X(06)00321-3

journal_volume

25

pub_type

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