Abstract:
:The International Agency for Research on Cancer recently released an assessment classifying red and processed meat as "carcinogenic to humans" on the basis of the positive association between increased consumption and risk for colorectal cancer. Diet, however, can also decrease the risk for colorectal cancer and be used as a chemopreventive strategy. Bioactive dietary molecules, such as n-3 polyunsaturated fatty acids, curcumin, and fermentable fiber, have been proposed to exert chemoprotective effects, and their molecular mechanisms have been the focus of research in the dietary/chemoprevention field. Using these bioactives as examples, this review surveys the proposed mechanisms by which they exert their effects, from the nucleus to the cellular membrane. In addition, we discuss emerging technologies involving the culturing of colonic organoids to study the physiological effects of dietary bioactives. Finally, we address future challenges to the field regarding the identification of additional molecular mechanisms and other bioactive dietary molecules that can be utilized in our fight to reduce the incidence of colorectal cancer.
journal_name
Annu Rev Nutrjournal_title
Annual review of nutritionauthors
Hou TY,Davidson LA,Kim E,Fan YY,Fuentes NR,Triff K,Chapkin RSdoi
10.1146/annurev-nutr-071715-051039subject
Has Abstractpub_date
2016-07-17 00:00:00pages
543-70eissn
0199-9885issn
1545-4312journal_volume
36pub_type
杂志文章,评审abstract::Much of the science underlying nutrition has come from biochemical studies. This certainly is true in our understanding of the metabolism and function of such micronutrient cofactors as vitamins and metal ions. My own interest stems from an early desire to understand the molecular events in an organism and ultimately ...
journal_title:Annual review of nutrition
pub_type: 传,历史文章,杂志文章
doi:10.1146/annurev.nutr.24.120203.113511
更新日期:2004-01-01 00:00:00
abstract::The health benefits of pre- and probiotics have been the subject of increased research interests. These food supplements have been demonstrated to alter the pre-existing intestinal flora so as to provide an advantage to the host. This review focuses on the scientific evidence both for and against their role in promoti...
journal_title:Annual review of nutrition
pub_type: 杂志文章,评审
doi:10.1146/annurev.nutr.22.110901.145412
更新日期:2002-01-01 00:00:00
abstract::Calcium requirements may vary throughout the lifespan. During the growth years and up to age 25-30, it is important to maximize dietary intake of calcium to maintain positive calcium balance and achieve peak bone mass, thereby possibly decreasing the risk of fracture when bone is subsequently lost. The RDA for age 10-...
journal_title:Annual review of nutrition
pub_type: 杂志文章,评审
doi:10.1146/annurev.nu.10.070190.002145
更新日期:1990-01-01 00:00:00
abstract::It appears that specific functions may be assigned to some of the cellular folate binding proteins with some degree of certainty. Those that are membrane bound or derived from membranes probably have a role in transport of folate molecules into the cell. This is in spite of the fact that the localization of this prote...
journal_title:Annual review of nutrition
pub_type: 杂志文章,评审
doi:10.1146/annurev.nu.02.070182.001305
更新日期:1982-01-01 00:00:00
abstract::The objective of this review is to evaluate the evidence for a link between maternal obesity and poor lactation performance. In nonhuman species, excess maternal fatness is deleterious for lactation and also for maternal health and survival. These effects occur during pregnancy and as milk production is beginning. The...
journal_title:Annual review of nutrition
pub_type: 杂志文章,评审
doi:10.1146/annurev.nutr.27.061406.093738
更新日期:2007-01-01 00:00:00
abstract::Since the late 1980s, there has been an explosion of information on the molecular mechanisms and functions of vitamin A. This review focuses on the essential role of vitamin A in female reproduction and embryonic development and the metabolism of vitamin A (retinol) that results in these functions. Evidence strongly s...
journal_title:Annual review of nutrition
pub_type: 杂志文章,评审
doi:10.1146/annurev.nutr.22.010402.102745E
更新日期:2002-01-01 00:00:00
abstract::Recent advances in the knowledge of iron metabolism underscore its complex relationship to overall cell metabolism. One of the key components of the iron uptake and storage pathway is ferritin, a protein that sequesters iron in a nontoxic form. Ferritin synthesis is translationally regulated by iron. Molecules such as...
journal_title:Annual review of nutrition
pub_type: 杂志文章,评审
doi:10.1146/annurev.nu.15.070195.001323
更新日期:1995-01-01 00:00:00
abstract::Mechanisms involved in the digestion and absorption of dietary vitamin A require the participation of several proteins. Dietary retinyl esters are hydrolyzed in the intestine by the pancreatic enzyme, pancreatic triglyceride lipase, and intestinal brush border enzyme, phospholipase B. Unesterified retinol taken up by ...
journal_title:Annual review of nutrition
pub_type: 杂志文章,评审
doi:10.1146/annurev.nutr.25.050304.092614
更新日期:2005-01-01 00:00:00
abstract::Fatty acid-binding proteins (FABPs) are abundant intracellular proteins that bind long-chain fatty acids with high affinity. Nine separate mammalian FABPs have been identified, and their tertiary structures are highly conserved. The FABPs have unique tissue-specific distributions that have long suggested functional di...
journal_title:Annual review of nutrition
pub_type: 杂志文章,评审
doi:10.1146/annurev.nutr.27.061406.093710
更新日期:2008-01-01 00:00:00
abstract::Birth and adaptation to extrauterine life involve major shifts in the protein and energy metabolism of the human newborn. These include a shift from a state of continuous supply of nutrients including amino acids from the mother to cyclic periodic oral intake, a change in the redox state of organs, thermogenesis, and ...
journal_title:Annual review of nutrition
pub_type: 杂志文章,评审
doi:10.1146/annurev.nutr.28.061807.155333
更新日期:2008-01-01 00:00:00
abstract::Emerging evidence suggests that ascorbate, the dominant form of vitamin C under physiological pH conditions, influences activity of the genome via regulating epigenomic processes. Ascorbate serves as a cofactor for Ten-eleven translocation (TET) dioxygenases that catalyze the oxidation of 5-methylcytosine (5mC) into 5...
journal_title:Annual review of nutrition
pub_type: 杂志文章,评审
doi:10.1146/annurev-nutr-071714-034228
更新日期:2015-01-01 00:00:00
abstract::Some of us who were born in the middle of Europe between World Wars I and II had to face quite a few unusual challenges that we all met in different ways. I was born and raised in Prague, Czechoslovakia, a country at the time of my birth that was governed by a Western style of democracy, which was later destroyed by t...
journal_title:Annual review of nutrition
pub_type: 传,历史文章,杂志文章
doi:10.1146/annurev.nutr.23.011702.073155
更新日期:2003-01-01 00:00:00
abstract::The "fetal origins" hypothesis postulates that conditions, most likely nutritional, "program" the fetus for the development of chronic diseases in adulthood. Associations between the newborn's size at birth and various determinants or consequences of chronic diseases have been identified in many, but not all, of the a...
journal_title:Annual review of nutrition
pub_type: 杂志文章,评审
doi:10.1146/annurev.nutr.21.1.73
更新日期:2001-01-01 00:00:00
abstract::There is a growing view that certain foods, particularly those high in refined sugars and fats, are addictive and that some forms of obesity can usefully be treated as a food addiction. This perspective is supported by a growing body of neuroscience research demonstrating that the chronic consumption of energy-dense f...
journal_title:Annual review of nutrition
pub_type: 杂志文章,评审
doi:10.1146/annurev-nutr-071715-050909
更新日期:2016-07-17 00:00:00
abstract::Trans fatty acids raise plasma low-density lipoprotein (LDL) cholesterol levels in volunteers when exchanged for cis unsaturated fatty acids in the diet. In addition, trans fatty acids may lower high-density lipoprotein (HDL) cholesterol levels and raise triglyceride and lipoprotein(a) levels in plasma. Trans and cis ...
journal_title:Annual review of nutrition
pub_type: 杂志文章,评审
doi:10.1146/annurev.nu.15.070195.002353
更新日期:1995-01-01 00:00:00
abstract::Lipolysis of white adipose tissue triacylglycerol stores results in the liberation of glycerol and nonesterified fatty acids that are released into the vasculature for use by other organs as energy substrates. In response to changes in nutritional state, lipolysis rates are precisely regulated through hormonal and bio...
journal_title:Annual review of nutrition
pub_type: 杂志文章,评审
doi:10.1146/annurev.nutr.27.061406.093734
更新日期:2007-01-01 00:00:00
abstract::The field of nutrigenomics shows tremendous promise for improved understanding of the effects of dietary intake on health. The knowledge that metabolic pathways may be altered in individuals with genetic variants in the presence of certain dietary exposures offers great potential for personalized nutrition advice. How...
journal_title:Annual review of nutrition
pub_type: 杂志文章,评审
doi:10.1146/annurev-nutr-072610-145203
更新日期:2013-01-01 00:00:00
abstract::The discovery of multiple selenoproteins has raised tantalizing questions about their role in maintaining normal cellular function. Unfortunately, many of these remain inadequately investigated. While they have a role in maintaining redox balance, other functions are becoming increasingly recognized. As the roles of t...
journal_title:Annual review of nutrition
pub_type: 杂志文章,评审
doi:10.1146/annurev-nutr-071811-150740
更新日期:2012-08-21 00:00:00
abstract::Taste is a chemical sense that aids in the detection of nutrients and guides food choice. A limited number of primary qualities comprise taste. Accumulating evidence has raised a question about whether fat should be among them. Most evidence indicates triacylglycerol is not an effective taste stimulus, though it clear...
journal_title:Annual review of nutrition
pub_type: 杂志文章,评审
doi:10.1146/annurev-nutr-080508-141108
更新日期:2009-01-01 00:00:00
abstract::Some coffee brewing techniques raise the serum concentration of total and low-density-lipoprotein cholesterol in humans, whereas others do not. The responsible factors are the diterpene lipids cafestol and kahweol, which make up about 1% (wt:wt) of coffee beans. Diterpenes are extracted by hot water but are retained b...
journal_title:Annual review of nutrition
pub_type: 杂志文章,评审
doi:10.1146/annurev.nutr.17.1.305
更新日期:1997-01-01 00:00:00
abstract::In summary, nutritionally directed alterations in thyroid hormone metabolism appear to be adaptive and to serve important protective roles in the overall economy of the body. These adjustments to nutrition are found at practically every level of thyroid regulation, beginning in the CNS and ending with the final action...
journal_title:Annual review of nutrition
pub_type: 杂志文章,评审
doi:10.1146/annurev.nu.09.070189.001221
更新日期:1989-01-01 00:00:00
abstract::A significant proportion of the population is either affected by or concerned about food allergy. Our knowledge about food allergens and how they stimulate the immune system has increased dramatically over the past decade. However, reasons for the increased prevalence of food allergy are not clear. The diagnosis of fo...
journal_title:Annual review of nutrition
pub_type: 杂志文章,评审
doi:10.1146/annurev.nutr.26.061505.111211
更新日期:2006-01-01 00:00:00
abstract::Obesity is now recognized as a serious chronic disease, but there is pessimism about how successful treatment can be. A general perception is that almost no one succeeds in long-term maintenance of weight loss. To define long-term weight loss success, we need an accepted definition. We propose defining successful long...
journal_title:Annual review of nutrition
pub_type: 杂志文章,评审
doi:10.1146/annurev.nutr.21.1.323
更新日期:2001-01-01 00:00:00
abstract::Apart from being an important macronutrient, dietary fat has recently gained much prominence for its role in regulating gene expression. Polyunsaturated fatty acids (PUFAs) affect gene expression through various mechanisms including, but not limited to, changes in membrane composition, intracellular calcium levels, an...
journal_title:Annual review of nutrition
pub_type: 杂志文章,评审
doi:10.1146/annurev.nutr.25.051804.101917
更新日期:2005-01-01 00:00:00
abstract::The effects of saturated fatty acids (SFAs) on cardiovascular disease (CVD) risk are modulated by the nutrients that replace them and their food matrices. Replacement of SFAs with polyunsaturated fatty acids has been associated with reduced CVD risk, although there is heterogeneity in both fatty acid categories. In co...
journal_title:Annual review of nutrition
pub_type: 杂志文章,评审
doi:10.1146/annurev-nutr-071714-034449
更新日期:2015-01-01 00:00:00
abstract::Caloric restriction (CR), the consumption of fewer calories without malnutrition, and reduced insulin and/or IGFI receptor signaling delay many age-related physiological changes and extend the lifespan of many model organisms. Here, we present and review microarray and biochemical studies indicating that the potent an...
journal_title:Annual review of nutrition
pub_type: 杂志文章,评审
doi:10.1146/annurev.nutr.27.061406.093743
更新日期:2007-01-01 00:00:00
abstract::The low-density lipoprotein (LDL) receptor (LDL-R) family consists of cell-surface receptors that recognize extracellular ligands and internalize them for degradation by lysosomes. The LDL-R is the prototype of this family, which also contains very-low-density lipoprotein receptors (VLDL-R), apolipoprotein E receptor ...
journal_title:Annual review of nutrition
pub_type: 杂志文章,评审
doi:10.1146/annurev.nutr.19.1.141
更新日期:1999-01-01 00:00:00
abstract::There is a great deal of interest in personalized, individualized, or precision interventions for disease and health-risk mitigation. This is as true of nutrition-based intervention and prevention strategies as it is for pharmacotherapies and pharmaceutical-oriented prevention strategies. Essentially, technological br...
journal_title:Annual review of nutrition
pub_type: 杂志文章,评审
doi:10.1146/annurev-nutr-071816-064717
更新日期:2017-08-21 00:00:00
abstract::Epidemiologic and experimental evidence reviewed in this article emphasizes the complex and multifactorial etiology of endemic goiter. The important role of iodine deficiency as an etiologic factor in endemic goiter is firmly established, but there is evidence that other environmental factors can play an equally impor...
journal_title:Annual review of nutrition
pub_type: 杂志文章,评审
doi:10.1146/annurev.nu.10.070190.000321
更新日期:1990-01-01 00:00:00
abstract::Nutrient content and nutrient timing are considered key regulators of human health and a variety of diseases and involve complex interactions with the mucosal immune system. In particular, the innate immune system is emerging as an important signaling hub that modulates the response to nutritional signals, in part via...
journal_title:Annual review of nutrition
pub_type: 杂志文章
doi:10.1146/annurev-nutr-120919-094440
更新日期:2020-09-23 00:00:00