Selenoproteins and cancer prevention.

Abstract:

:The discovery of multiple selenoproteins has raised tantalizing questions about their role in maintaining normal cellular function. Unfortunately, many of these remain inadequately investigated. While they have a role in maintaining redox balance, other functions are becoming increasingly recognized. As the roles of these selenoproteins are further characterized, a better understanding of the true physiological significance of this trace element will arise. This knowledge will be essential in defining optimum intakes to achieve cellular homeostasis in order to optimize health, including a reduction in cancer, for diverse populations. Human variation in the response to selenium likely reflects significant interactions between the type and amounts of selenium consumed with the genome and a host of environmental factors including the totality of the diet, as discussed in this review.

journal_name

Annu Rev Nutr

authors

Davis CD,Tsuji PA,Milner JA

doi

10.1146/annurev-nutr-071811-150740

subject

Has Abstract

pub_date

2012-08-21 00:00:00

pages

73-95

eissn

0199-9885

issn

1545-4312

journal_volume

32

pub_type

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