Abstract:
:Apart from being an important macronutrient, dietary fat has recently gained much prominence for its role in regulating gene expression. Polyunsaturated fatty acids (PUFAs) affect gene expression through various mechanisms including, but not limited to, changes in membrane composition, intracellular calcium levels, and eicosanoid production. Furthermore, PUFAs and their various metabolites can act at the level of the nucleus, in conjunction with nuclear receptors and transcription factors, to affect the transcription of a variety of genes. Several of these transcription mediators have been identified and include the nuclear receptors peroxisome proliferator-activated receptor (PPAR), hepatocyte nuclear factor (HNF)-4alpha, and liver X receptor (LXR) and the transcription factors sterol-regulatory element binding protein (SREBP) and nuclear factor-kappaB (NFkappaB). Their interaction with PUFAs has been shown to be critical to the regulation of several key genes of lipid metabolism. Working out the mechanisms by which these interactions and consequent effects occur is proving to be complicated but is invaluable to our understanding of the role that dietary fat can play in disease management and prevention.
journal_name
Annu Rev Nutrjournal_title
Annual review of nutritionauthors
Sampath H,Ntambi JMdoi
10.1146/annurev.nutr.25.051804.101917subject
Has Abstractpub_date
2005-01-01 00:00:00pages
317-40eissn
0199-9885issn
1545-4312journal_volume
25pub_type
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journal_title:Annual review of nutrition
pub_type: 杂志文章,评审
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journal_title:Annual review of nutrition
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journal_title:Annual review of nutrition
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journal_title:Annual review of nutrition
pub_type: 杂志文章,评审
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更新日期:2002-01-01 00:00:00
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journal_title:Annual review of nutrition
pub_type: 杂志文章,评审
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更新日期:2016-07-17 00:00:00
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journal_title:Annual review of nutrition
pub_type: 杂志文章,评审
doi:10.1146/annurev.nu.15.070195.002353
更新日期:1995-01-01 00:00:00
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journal_title:Annual review of nutrition
pub_type: 杂志文章,评审
doi:10.1146/annurev-nutr-071715-050916
更新日期:2016-07-17 00:00:00
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journal_title:Annual review of nutrition
pub_type: 杂志文章,评审
doi:10.1146/annurev.nutr.17.1.77
更新日期:1997-01-01 00:00:00
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journal_title:Annual review of nutrition
pub_type: 杂志文章
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更新日期:2020-09-23 00:00:00
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journal_title:Annual review of nutrition
pub_type: 杂志文章,评审
doi:10.1146/annurev.nutr.20.1.395
更新日期:2000-01-01 00:00:00
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journal_title:Annual review of nutrition
pub_type: 杂志文章,评审
doi:10.1146/annurev-nutr-072610-145203
更新日期:2013-01-01 00:00:00
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journal_title:Annual review of nutrition
pub_type: 传,历史文章,杂志文章
doi:10.1146/annurev.nutr.24.120203.113511
更新日期:2004-01-01 00:00:00
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journal_title:Annual review of nutrition
pub_type: 杂志文章,评审
doi:10.1146/annurev.nutr.26.061505.111303
更新日期:2006-01-01 00:00:00
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journal_title:Annual review of nutrition
pub_type: 杂志文章,评审
doi:10.1146/annurev-nutr-080508-141108
更新日期:2009-01-01 00:00:00
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journal_title:Annual review of nutrition
pub_type: 杂志文章,评审
doi:10.1146/annurev.nu.10.070190.000321
更新日期:1990-01-01 00:00:00
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journal_title:Annual review of nutrition
pub_type: 杂志文章,评审
doi:10.1146/annurev.nutr.25.050304.092545
更新日期:2007-01-01 00:00:00
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journal_title:Annual review of nutrition
pub_type: 杂志文章,评审
doi:10.1146/annurev.nutr.25.050304.092610
更新日期:2006-01-01 00:00:00
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journal_title:Annual review of nutrition
pub_type: 杂志文章,评审
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更新日期:2003-01-01 00:00:00
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journal_title:Annual review of nutrition
pub_type: 杂志文章,评审
doi:10.1146/annurev-nutr-071812-161215
更新日期:2014-01-01 00:00:00
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journal_title:Annual review of nutrition
pub_type: 杂志文章,评审
doi:10.1146/annurev.nu.02.070182.001221
更新日期:1982-01-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2014-01-01 00:00:00
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journal_title:Annual review of nutrition
pub_type: 杂志文章,评审
doi:10.1146/annurev.nu.16.070196.000445
更新日期:1996-01-01 00:00:00
abstract::There is a great deal of interest in personalized, individualized, or precision interventions for disease and health-risk mitigation. This is as true of nutrition-based intervention and prevention strategies as it is for pharmacotherapies and pharmaceutical-oriented prevention strategies. Essentially, technological br...
journal_title:Annual review of nutrition
pub_type: 杂志文章,评审
doi:10.1146/annurev-nutr-071816-064717
更新日期:2017-08-21 00:00:00
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journal_title:Annual review of nutrition
pub_type: 杂志文章,评审
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更新日期:1987-01-01 00:00:00
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journal_title:Annual review of nutrition
pub_type: 杂志文章,评审
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更新日期:2011-08-21 00:00:00
abstract::Selenium exerts its biological activity largely through selenoproteins, which contain the element in the form of selenocysteine. Five selenoproteins have been characterized in animal tissues and there is evidence that a number of others exist. Selenoprotein synthesis is a complex process that has been well characteriz...
journal_title:Annual review of nutrition
pub_type: 杂志文章,评审
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更新日期:1993-01-01 00:00:00
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journal_title:Annual review of nutrition
pub_type: 杂志文章,评审
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更新日期:2007-01-01 00:00:00
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journal_title:Annual review of nutrition
pub_type: 传,历史文章,杂志文章
doi:10.1146/annurev.nutr.23.011702.073155
更新日期:2003-01-01 00:00:00
abstract::The discovery of multiple selenoproteins has raised tantalizing questions about their role in maintaining normal cellular function. Unfortunately, many of these remain inadequately investigated. While they have a role in maintaining redox balance, other functions are becoming increasingly recognized. As the roles of t...
journal_title:Annual review of nutrition
pub_type: 杂志文章,评审
doi:10.1146/annurev-nutr-071811-150740
更新日期:2012-08-21 00:00:00
abstract::The "fetal origins" hypothesis postulates that conditions, most likely nutritional, "program" the fetus for the development of chronic diseases in adulthood. Associations between the newborn's size at birth and various determinants or consequences of chronic diseases have been identified in many, but not all, of the a...
journal_title:Annual review of nutrition
pub_type: 杂志文章,评审
doi:10.1146/annurev.nutr.21.1.73
更新日期:2001-01-01 00:00:00