Abstract:
:Recent advances in the knowledge of iron metabolism underscore its complex relationship to overall cell metabolism. One of the key components of the iron uptake and storage pathway is ferritin, a protein that sequesters iron in a nontoxic form. Ferritin synthesis is translationally regulated by iron. Molecules such as nitric oxide and cytokines also affect transcriptional and/or posttranscriptional ferritin synthesis. Conversely, iron-containing molecules affect expression of mitochondrial aconitase, erythroid aminolevulinic acid synthase, and nitric oxide synthase. This observation indicates a complex linkage between iron metabolism and a variety of other important cell activities. The finding that the cytoplasmic iron-responsive protein (IRP) has two forms also raises intriguing questions about the relationship between the cytoplasmic aconitase and translational regulation of mRNAs such as ferritin. At least one of the IRPs can be phosphorylated. These recent discoveries open exciting new avenues for research that should lead to a better understanding of cellular iron metabolism.
journal_name
Annu Rev Nutrjournal_title
Annual review of nutritionauthors
Mascotti DP,Rup D,Thach REdoi
10.1146/annurev.nu.15.070195.001323subject
Has Abstractpub_date
1995-01-01 00:00:00pages
239-61eissn
0199-9885issn
1545-4312journal_volume
15pub_type
杂志文章,评审abstract::Taste is a chemical sense that aids in the detection of nutrients and guides food choice. A limited number of primary qualities comprise taste. Accumulating evidence has raised a question about whether fat should be among them. Most evidence indicates triacylglycerol is not an effective taste stimulus, though it clear...
journal_title:Annual review of nutrition
pub_type: 杂志文章,评审
doi:10.1146/annurev-nutr-080508-141108
更新日期:2009-01-01 00:00:00
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journal_title:Annual review of nutrition
pub_type: 杂志文章,评审
doi:10.1146/annurev-nutr-072610-145216
更新日期:2011-08-21 00:00:00
abstract::The biosynthesis of one riboflavin molecule requires one molecule of GTP and two molecules of ribulose 5-phosphate as substrates. The imidazole ring of GTP is hydrolytically opened, yielding a 4, 5-diaminopyrimidine which is converted to 5-amino-6-ribitylamino-2, 4(1H,3H)-pyrimidinedione by a sequence of deamination, ...
journal_title:Annual review of nutrition
pub_type: 杂志文章,评审
doi:10.1146/annurev.nutr.20.1.153
更新日期:2000-01-01 00:00:00
abstract::Caloric restriction (CR), the consumption of fewer calories without malnutrition, and reduced insulin and/or IGFI receptor signaling delay many age-related physiological changes and extend the lifespan of many model organisms. Here, we present and review microarray and biochemical studies indicating that the potent an...
journal_title:Annual review of nutrition
pub_type: 杂志文章,评审
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更新日期:2007-01-01 00:00:00
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journal_title:Annual review of nutrition
pub_type: 杂志文章,评审
doi:10.1146/annurev.nutr.17.1.559
更新日期:1997-01-01 00:00:00
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journal_title:Annual review of nutrition
pub_type: 杂志文章,评审
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更新日期:2012-08-21 00:00:00
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journal_title:Annual review of nutrition
pub_type: 杂志文章,评审
doi:10.1146/annurev.nutr.23.011702.073247
更新日期:2003-01-01 00:00:00
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journal_title:Annual review of nutrition
pub_type: 杂志文章,评审
doi:10.1146/annurev.nu.08.070188.002031
更新日期:1988-01-01 00:00:00
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journal_title:Annual review of nutrition
pub_type: 杂志文章,评审
doi:10.1146/annurev.nutr.23.020102.075739
更新日期:2003-01-01 00:00:00
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journal_title:Annual review of nutrition
pub_type: 杂志文章,评审
doi:10.1146/annurev-nutr-071715-050916
更新日期:2016-07-17 00:00:00
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journal_title:Annual review of nutrition
pub_type: 杂志文章,评审
doi:10.1146/annurev.nu.02.070182.001221
更新日期:1982-01-01 00:00:00
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journal_title:Annual review of nutrition
pub_type: 杂志文章,评审
doi:10.1146/annurev.nutr.26.061505.111214
更新日期:2006-01-01 00:00:00
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journal_title:Annual review of nutrition
pub_type: 杂志文章,评审
doi:10.1146/annurev.nu.15.070195.002353
更新日期:1995-01-01 00:00:00
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journal_title:Annual review of nutrition
pub_type: 杂志文章,评审
doi:10.1146/annurev.nutr.23.011702.073237
更新日期:2004-01-01 00:00:00
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journal_title:Annual review of nutrition
pub_type: 杂志文章,评审
doi:10.1146/annurev.nutr.24.012003.132315
更新日期:2004-01-01 00:00:00
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journal_title:Annual review of nutrition
pub_type: 杂志文章,评审
doi:10.1146/annurev.nu.10.070190.002145
更新日期:1990-01-01 00:00:00
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journal_title:Annual review of nutrition
pub_type: 传,历史文章,杂志文章
doi:10.1146/annurev.nutr.24.120203.113511
更新日期:2004-01-01 00:00:00
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journal_title:Annual review of nutrition
pub_type: 杂志文章
doi:10.1146/annurev-nutr-082117-051805
更新日期:2018-08-21 00:00:00
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journal_title:Annual review of nutrition
pub_type: 杂志文章
doi:10.1146/annurev-nutr-120919-094440
更新日期:2020-09-23 00:00:00
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journal_title:Annual review of nutrition
pub_type: 杂志文章,评审
doi:10.1146/annurev.nutr.25.051804.101917
更新日期:2005-01-01 00:00:00
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journal_title:Annual review of nutrition
pub_type: 杂志文章,评审
doi:10.1146/annurev-nutr-071812-161156
更新日期:2014-01-01 00:00:00
abstract::Variants in the FADS gene cluster modify the activity of polyunsaturated fatty acid (PUFA) desaturation and the lipid composition in human blood and tissue. FADS variants have been associated with plasma lipid concentrations, risk of cardiovascular diseases, overweight, eczema, pregnancy outcomes, and cognitive functi...
journal_title:Annual review of nutrition
pub_type: 杂志文章,评审
doi:10.1146/annurev-nutr-082018-124250
更新日期:2019-08-21 00:00:00
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journal_title:Annual review of nutrition
pub_type: 杂志文章,评审
doi:10.1146/annurev-nutr-071715-051039
更新日期:2016-07-17 00:00:00
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journal_title:Annual review of nutrition
pub_type: 杂志文章,评审
doi:10.1146/annurev.nutr.25.050304.092614
更新日期:2005-01-01 00:00:00
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journal_title:Annual review of nutrition
pub_type: 杂志文章,评审
doi:10.1146/annurev.nutr.22.110901.145412
更新日期:2002-01-01 00:00:00
abstract::It is clear that many diseases are known to involve defects in vitamin B6 metabolism, but that even more await definitive studies. Furthermore, some functions of vitamin B6, such as its role in glucocorticoid action (21), have been discovered so recently that the medical implications have not yet been fully explored. ...
journal_title:Annual review of nutrition
pub_type: 杂志文章,评审
doi:10.1146/annurev.nu.07.070187.001033
更新日期:1987-01-01 00:00:00
abstract::Thirty years ago, it was suggested that maternal intake of certain vitamins during pregnancy affected the incidence of serious fetal malformations. Subsequent research has revealed that folate (folic acid), a B vitamin, plays a crucial role in the development of the central nervous system during the early weeks of ges...
journal_title:Annual review of nutrition
pub_type: 杂志文章,评审
doi:10.1146/annurev.nu.16.070196.000445
更新日期:1996-01-01 00:00:00
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journal_title:Annual review of nutrition
pub_type: 杂志文章,评审
doi:10.1146/annurev.nu.10.070190.000321
更新日期:1990-01-01 00:00:00
abstract::Glucose is an essential nutrient for the human body. It is the major energy source for many cells, which depend on the bloodstream for a steady supply. Blood glucose levels, therefore, are carefully maintained. The liver plays a central role in this process by balancing the uptake and storage of glucose via glycogenes...
journal_title:Annual review of nutrition
pub_type: 杂志文章,评审
doi:10.1146/annurev.nutr.19.1.379
更新日期:1999-01-01 00:00:00
abstract::Dietary guidelines are formulated to meet minimum nutrient requirements, which prevent deficiencies and maintain health, growth, development, and function. These guidelines can be inadequate and contribute to disrupted homeostasis, lean body mass loss, and deteriorated performance in individuals who are working long, ...
journal_title:Annual review of nutrition
pub_type: 杂志文章
doi:10.1146/annurev-nutr-011720-122637
更新日期:2020-09-23 00:00:00